Improving viral vector safety for gene therapies
Drug Discovery World
AUGUST 21, 2024
Unlike lentiviral vectors, which are fundamentally integrated into the host genome, recombinant AAV remains episomal after transduction into the nucleus of the host cells; however, data has shown AAV may integrate into the host genome in a random, non-homologous manner. The frequency of AAV integration has been estimated at 0.1%
59 
Let's personalize your content