pharmaphorum

NOVEMBER 7, 2022

1910 Genetics, a biotechnology company integrating artificial intelligence (AI), computation and biological automation to accelerate the design of small molecule and protein therapeutics, has appointed Patrick Genestin as chief business officer. .” Patrick Genestin, 1910 Genetics .

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Life Science Genetics Business Development Marketing 105

XTalks

MAY 10, 2023

The treatment, an antisense oligonucleotide developed by Biogen, targets abnormal proteins arising from SOD1 mutations, which are associated with the development of ALS in some patients. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

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Life Science Vaccination Vaccine FDA Approval 52

XTalks

FEBRUARY 29, 2024

Dual-function fusion proteins represent a cutting-edge approach in biopharmaceutical research, offering a promising avenue for the development of novel therapeutics in the treatment of complex diseases such as cancer and autoimmune disorders. At the helm of this venture is Dr. Taylor H. How is your lead program differentiated?

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Protein Development Clinical Trials Clinical Trials 72

XTalks

DECEMBER 17, 2021

Xtalks is taking a look at some of the major stories and innovations of the year in the life sciences, many of which were driven by new, emerging and improved technologies. The year 2021 was all about continuing innovations in the life sciences. Life Science Innovations: Malaria and Influenza Vaccines.

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Life Science Vaccination Vaccine Trials 92

XTalks

MARCH 31, 2023

By growing high quality crystal structures of protein-based therapeutics under microgravity, researchers can gain better insights into their complex structures and stability. The proteins will be analyzed back on Earth using techniques such as X-ray diffraction and compared with crystals from the same biologics grown on Earth.

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Protein Research Development Manufacturing 86

XTalks

JANUARY 19, 2022

The research shows that exercise increases levels of synaptic proteins in the brain involved in maintaining and strengthening neuronal connections. The researchers also found these proteins could be protective even in people with dementia and other neurodegenerative diseases like Alzheimer’s.

Life Science 52

Life Science Protein Development Research 52

XTalks

JANUARY 5, 2021

There will also be more focus on digitization of research and development and manufacturing spaces to increase efficiencies and interconnectivity in the pharma, biotech and medical device industries. The test identifies SARS-CoV-2 protein fragments from nasal swab samples. 1. COVID-19 Pandemic: An Evolving Era.

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XTalks

AUGUST 8, 2024

Dieterich has a PhD in synthetic organic chemistry, an MBA from Imperial College London and a wealth of experience in drug development and chemistry, manufacturing and control (CMC) activities. Abzena is a leader in bioconjugation and ADC development. They act by modifying protein expression, offering new treatments for rare diseases.

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Development Medicine Antibody Protein 64

XTalks

OCTOBER 1, 2024

mRNA therapies work by instructing cells to produce specific proteins that can enhance the body’s natural defenses or correct deficiencies. ETH47, Ethris’ investigational mRNA therapeutic, is designed to address this vulnerability by encoding for interferon lambda, a crucial protein in the immune response. “By

Development 52

Development Drugs Immune Response Protein 52

Scienmag

FEBRUARY 5, 2021

Membrane-localized phage proteins may also help revitalize, enhance existing antibiotics A study from the Center for Phage Technology, part of Texas A&M’s College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the “hidden” genes in bacteriophages — types of viruses that infect and destroy (..)

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Gene Bacteria Life Science Development 74

XTalks

MAY 7, 2021

As Novavax awaits emergency use authorization (EUA) from the US Food and Drug Administration (FDA) for its protein-based COVID-19 vaccine NVX-CoV2373, the company shared new data this week on the vaccine’s efficacy against the South African B.1.351 Glenn, president of research and development at Novavax, in a news release. “It

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Protein Vaccination Vaccine Trials 85

pharmaphorum

JULY 18, 2022

“It is programmed and coded for the production of the full-length spike protein of the coronavirus. It then elicits an immune response against that spike protein. Pierre has over 35 years of experience in the global life science industry in specialty care, vaccines and immunotherapy and has been CEO of several start-ups.

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Vaccination Vaccine Development Immune Response 135

XTalks

JANUARY 23, 2024

Among these, rare pediatric diseases present unique challenges and opportunities for rare disease drug development. Pediatric growth hormone deficiency (PGHD) is one such condition, affecting a child’s growth and development. This venture also led me to identify a gap in the market for contract manufacturing of recombinant proteins.

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Development Hormones Drugs Trials 72

pharmaphorum

JULY 26, 2021

The most complete database of protein structures ever assembled, developed with the help of Google’s artificial intelligence unit DeepMind, has been made freely available to researchers around the world. Around a third of the structures are considered to be detailed and precise enough to allow drug design.

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Protein Genome Genomics Life Science 130

Pharmaceutical Technology

MARCH 10, 2023

On 10 March, the National Health Service Blood and Transplant (NHSBT) opened a new Clinical Biotechnology Centre (CBC) with the aim of improving the UK’s ability to develop and manufacture cell and gene therapies. Personalised medicines will also be developed at the centre.

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Gene Therapy Manufacturing Gene Clinical Trials 264

Roots Analysis

JANUARY 23, 2024

Owing to the challenges involved in the synthesis process and demands of modern drug development, majority of drug developers in this domain prefer to outsource their development and manufacturing operations to peptide therapeutics contract API manufacturers as a strategic solution to streamline their research and peptide synthesis efforts.

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Development Contract Manufacturing Drugs Manufacturing 40

Pharmaceutical Technology

MARCH 1, 2023

Nedisertib is under clinical development by Merck and currently in Phase I for Neuroendocrine Tumors. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Merck KG, is a science and technology company.

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Gene Editing DNA Cosmetics Life Science 100

Pharmaceutical Technology

MARCH 1, 2023

Nedisertib is under clinical development by Merck and currently in Phase I for Head And Neck Cancer Squamous Cell Carcinoma. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. It is a new chemical entity.

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Gene Editing DNA Cosmetics Life Science 100

The Pharma Data

NOVEMBER 10, 2020

“Paul is a seasoned leader with a significant track record of accomplishment in the life sciences industry,” said Chase Coffman, co-founder and CEO, Elektrofi. Herbert is a pioneer and leading expert in product development and manufacturing for particle-based products and has led the development of twelve processes to NDA submission.

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Development Engineer Manufacturing Life Science 52

pharmaphorum

MARCH 23, 2021

US biotech Aura Biosciences has closed an oversubscribed financing, raising $80 million to help take its lead virus-like drug conjugate (VDC) for a cancer that affects the eye into late-stage development. The post Aura raises $80m to develop its virus-like cancer drugs appeared first on.

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Development Drugs Immune Response Life Science 66

XTalks

FEBRUARY 19, 2024

The study compared the immune responses evoked by Moderna’s mRNA vaccine to those generated by a previous vaccine candidate, namely, the MF59-adjuvanted glycoprotein B (gB) proten subunit vaccine (gB/MF59) developed by Sanofi. However, the development of an effective vaccine that can target CMV infection has been extremely challenging.

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Vaccination Vaccine Trials Clinical Trials 59

XTalks

NOVEMBER 7, 2024

Duchenne’s hallmark is the lack of dystrophin, a protein essential for muscle health. Developed by Amgen, Imdelltra is the first FDA-approved bispecific T-cell engager (BiTE) therapy for extensive-stage small cell lung cancer (ES-SCLC), an aggressive cancer often resistant to traditional treatments.

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Gene Therapy Gene Editing Gene FDA Approval 96

Pharmaceutical Technology

APRIL 18, 2023

Innovation S-curve for the pharmaceutical industry HIV peptides is a key innovation area in pharmaceuticals HIV peptides are fragments derived from HIV envelope gp160 protein, the HIV matrix/capsid proteins, and the HIV gag, pol and env gene products.

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Protein Vaccination Vaccine Production 147

Scienmag

NOVEMBER 2, 2020

“The protein alpha-synuclein is thought to play a central role in neurodegenerative diseases, and is one of the most investigated targets for developing diagnostics and therapies for Parkinson’s disease,” explains Hilal Lashuel, director of the Lashuel lab at EPFL’s School of Life Sciences.

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Life Science Protein Development Engineer 50

XTalks

APRIL 14, 2022

In a joint press release with UK-based ReViral, Pfizer said the nearly $525 million deal will help strengthen its infectious disease research and development portfolio with a “complementary strategy” involving both treatments for RSV to improve patient outcomes, and vaccination to prevent illness. billion, if successful.

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Development Vaccination Vaccine Protein 52

XTalks

MAY 10, 2022

On Saturday, researchers at the Children’s Hospital of Philadelphia (CHOP) have announced that they developed and launched a new bioinformatics software tool called CancerVar (cancer variant interpretation). Why Was CancerVar Developed? What is CancerVar? This software is implemented in Python and has a user-friendly web server.

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Bioinformatics Development Gene Genome 93

BioTech 365

OCTOBER 8, 2020

Confidently assess protein candidates faster and with more flexibility to accelerate biotherapeutic development programs. –(BUSINESS WIRE)–SCIEX, a global leader in life science analytical technologies, announced today the launch of BPV Flex 2.1, FRAMINGHAM, Mass.–(BUSINESS

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Life Science Protein Development 40

Pharmaceutical Technology

JUNE 4, 2023

There are two main genes in the AAV genome, rep and cap, which encode nine different proteins. Transcription of the rep gene is initiated from the p5 or p19 promoters to, respectively, produce the large (Rep78 and Rep68) and small (Rep52 and Rep40) nonstructural Rep proteins.

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Gene Gene Therapy Genetics DNA 262

Pharmaceutical Technology

NOVEMBER 22, 2022

Vaccines are our number one weapon in the fight against infectious diseases, but their development has historically involved a long and complex process taking up to a decade. Before COVID-19, Merck held the record for the fastest modern vaccine ever developed. The UK Government is behind this effort.

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The Pharma Data

NOVEMBER 23, 2020

EVOTEC TO SUPPORT RAPPTA IN DEVELOPING SMALL MOLECULES THAT REACTIVATE PP2A, A KEY TUMOR SUPPRESSOR. THE COLLABORATION LEVERAGES EVOTEC’S ONCOLOGY EXPERTISE AND INTEGRATED DRUG DISCOVERY AND DEVELOPMENT PLATFORM. This is the perfect combination of expertise to translate these discoveries to the clinic.”

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Development Protein Regulation Drugs 40

XTalks

OCTOBER 12, 2021

Last week, a study that “stumbled upon” a vaccine for rheumatoid arthritis (RA) was published in the Proceedings of the National Academy of Sciences. The experimental arthritis vaccine was developed by researchers at the University of Toledo (UToledo) and is a major breakthrough for rheumatoid arthritis and other autoimmune diseases as well.

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pharmaphorum

JULY 20, 2021

The vaccine – now dubbed Vidprevtyn – is based on a recombinant protein antigen developed by Sanofi’s vaccines unit Sanofi Pasteur, and also includes an immune-boosting adjuvant developed by GSK that aims to boost its efficacy.

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Vaccination Vaccine Protein Immune Response 98

The Pharma Data

JANUARY 18, 2021

Experienced executive development team from Gilead Sciences. a clinical-stage biotechnology company focused on developing treatments for immunological and inflammatory diseases, today announced its launch backed by $80 million Series C financing led by Abingworth LLP. . SOUTH SAN FRANCISCO, Calif. ,

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Development Life Science Protein Clinical Development 52

XTalks

AUGUST 8, 2022

Medicxi is a prominent international life sciences investment firm that invested in over 60 portfolio companies such as Versanis Bio, Rivus Pharmaceuticals, Capella Bioscience and more. One of Medicxi’s portfolio companies called MiroBio is set to be acquired by Gilead Sciences for approximately $405 million in cash.

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The Pharma Data

OCTOBER 26, 2020

The agreement covers the gene therapy program targeting OTOF (OTOF-GT), the gene encoding the otoferlin protein. Through this agreement, Novasep’s expertise in the field of viral vector development and manufacturing is once again recognized and valued,” said Cedric Volanti , Novasep’s President of Biopharma Solutions. About Sensorion.

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Gene Therapy Gene Manufacturing Production 52

XTalks

OCTOBER 22, 2024

transmembrane tight junction protein, which is commonly found in some gastric and GEJ cancers. gene, and an estimated 60 percent of all gastric cancers harbor the protein. The drug is specifically indicated for patients whose tumors are HER2-negative and express claudin 18.2 targeting antibody-drug conjugate.

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FDA Approval Drugs Licensing Licensing 98

XTalks

DECEMBER 12, 2023

Plasma medicine is a critical and specialized field within healthcare, centering on the use of human plasma for the development and administration of life-saving treatments. Patients have better quality of life thanks to many Grifols plasma-derived medicines that replace missing or deficient plasma proteins.

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Medicine Recombinant Antibody Protein Antibody 109