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Preclinical data demonstrated that HB-500 was well-tolerated, eliciting robust, high-quality and enduring immuneresponses, including antigen-specific T cells and antibodies, in non-human primates. In November 2023, Hookipa Pharma Inc., Notably, it significantly reduced viral load and clinical illness compared to a placebo.
Credit: Earlham Institute Respiratory viruses such as SARS-CoV-2 (causing COVID-19) can often catalyse an overactive immuneresponse that leads to a life-threatening cycle, known as a cytokine storm.
Delivering vaccines directly to the lungs can boost immuneresponses to respiratory infections or lung cancer, study finds. CAMBRIDGE, MA — Many viruses infect their hosts through mucosal surfaces such as the lining of the respiratory tract.
The trial’s primary objective is to assess the safety of VIR-1388 and its capacity to stimulate a specific immuneresponse against HIV in study participants. This groundbreaking endeavor has received support from the National Institute of Allergy and Infectious Diseases (NIAID).
Moderna’s COVID-19 vaccine triggers an immuneresponse in older adults. The phase 1 study that is being run by the National Institute of Allergy and Infectious Diseases tests three dose levels of the vaccine, mRNA-1273, given in two injections a month apart in 120 adults.
Department of Health and Human Services (HHS), and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH) at HHS. NVX-CoV2373 is a protein-based vaccine candidate engineered from the genetic sequence of the first strain of SARS-CoV-2, the virus that causes COVID-19 disease.
But some patients develop resistance to current immunotherapies and others have cancers characterized by immunologically “cold” tumors, which evade or suppress the patient’s immuneresponse against his or her cancer.
These companies include Moderna, a US biotech company which has formed a partnership with the National Institute of Allergy and Infectious Diseases (NIAID), Oxford University who has partnered with AstraZeneca, and Johnson & Johnson, Merck and Pfizer. China’s COVID-19 Vaccine: Sinovac Biotech and CanSino Biologics.
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