Vaccine - Clinical Research Informer

AstraZeneca admits Covid-19 vaccine may cause blood clots in “very rare” cases

Pharmaceutical Technology

MAY 1, 2024

AstraZeneca has maintained that while the vaccine may, in “very rare” cases, cause TTS, the casual mechanism for this effect remains unknown.

Vaccination

Vaccination Vaccine

GSK raises forecasts on strong vaccine, HIV drug sales

Bio Pharma Dive

MAY 1, 2024

Sales of the shingles vaccine Shingrix and the RSV shot Arexvy helped fuel quarterly revenue totals that surpassed analyst expectations, though the company warned momentum could slow in the months ahead.

Sales

Sales Vaccination Vaccine Drugs

MHRA agrees licence change for Pfizer-BioNTech’s Comirnaty vaccine

Pharmaceutical Technology

FEBRUARY 12, 2024

vaccine targeting Omicron variant. The UK MHRA has granted approval for a variation in licence of Pfizer-BioNTech’s Comirnaty XBB.1.5

Vaccination

Vaccination Vaccine

Breakthrough Vaccine Shows High Protection Against Drug-Resistant Superbug in Mice

AuroBlog - Aurous Healthcare Clinical Trials blog

MAY 1, 2024

Scientists have developed a vaccine against a notorious drug-resistant superbug, targeting molecules on its surface that are also found on other bacteria and fungi.

Vaccination

Vaccination Vaccine Bacteria Drugs

Mandatory COVID Vaccination Policy Template

Advertiser: Aggregage

New vaccine mandates and testing policies will affect employers with more than 100 workers. Get Paycor’s free, customizable vaccination policy template to communicate critical details and new requirements to your employees. Get Paycor’s Template today!

Vaccination

Breaking barriers: Advances and challenges in therapeutic cancer vaccines

Bio Pharma Dive

APRIL 1, 2024

The development of cancer vaccines has provided some hope in the battle against cancer worldwide; however, there are still many challenges to overcome when developing these life-saving treatments.

Vaccination

Vaccination Vaccine Development

CDC panel mulls changes to RSV vaccine recommendation

Bio Pharma Dive

MARCH 1, 2024

The expert committee is discussing whether, for certain older adults, to make a universal recommendation for vaccination, rather than the current policy of “shared decisionmaking.”

Vaccination

Vaccination Vaccine

Moderna leads the development of mRNA vaccines in infectious diseases

Pharmaceutical Technology

JANUARY 29, 2024

The rapid sequencing of the SARS-CoV-2 and the subsequent development of mRNA vaccines led to the authorisation of the first of these vaccines in late 2020.

Vaccination

Vaccination Vaccine Development

SK bioscience’s typhoid vaccine receives WHO prequalification

Pharmaceutical Technology

FEBRUARY 26, 2024

SK bioscience has achieved a significant milestone with its typhoid conjugate vaccine, SKYTyphoid, receiving WHO prequalification.

Vaccination

Vaccination Vaccine

Cancer Research UK and CRIS fund lung cancer vaccine research

Pharmaceutical Technology

MARCH 25, 2024

Cancer Research UK and the CRIS Cancer Foundation have awarded a £1.7m ($2.1m) grant for developing the lung cancer vaccine LungVax.

Vaccination

Vaccination Vaccine Research Development

Moderna gets grant for vaccine composition for varicella zoster virus

Pharmaceutical Technology

APRIL 23, 2024

Discover how Moderna's groundbreaking patent for a nucleic acid vaccine targeting varicella zoster virus could revolutionize immunization. Learn about the innovative mRNA and lipid nanoparticle technology driving this game-changing vaccine.

Vaccination

Vaccination Vaccine

Pfizer wins FDA approval of new meningococcal vaccine

Bio Pharma Dive

OCTOBER 23, 2023

The clearance of the pentavalent shot Penbraya adds to Pfizer’s infectious disease portfolio as it adjusts to slumping COVID-19 vaccine sales.

FDA Approval

FDA Approval Vaccination Vaccine Sales

BioNTech’s RNA vaccine sparks potential in pancreatic cancer

Pharmaceutical Technology

MAY 11, 2023

Results published in Nature for a personalised pancreatic cancer vaccine that uses neoantigens from patients’ tumours have lent further support to early positive signals. The vaccine, developed by BioNTech, led to half of the patients with pancreatic cancer in the Phase I trial remaining cancer-free 18 months later.

RNA

RNA Vaccination Vaccine Trials

Repertoire and Bristol Myers Squibb link on autoimmune disease vaccines

Pharmaceutical Technology

APRIL 30, 2024

Repertoire Immune has collaborated with Bristol Myers Squibb to develop tolerising vaccines aimed at treating autoimmune diseases.

Vaccination

Vaccination Vaccine Development

BioNTech targets infectious diseases for vaccine development

Pharmaceutical Technology

MARCH 28, 2023

Following on from its Covid-19 vaccine programmes, BioNTech has set its sights on a range of infectious diseases for vaccine development. The company saw major successes with its Covid-19 vaccine, developed in collaboration with Pfizer. In response to the lower vaccine sales forecasts, BioNTech shares opened at 3.9%

Vaccination

Vaccination Vaccine Development Clinical Trials

ImmunityBio partners with Serum Institute for BCG vaccines

Pharmaceutical Technology

MAY 3, 2024

ImmunityBio has entered a worldwide agreement with the Serum Institute of India to secure a supply of BCG vaccine for all cancer types.

Vaccination

Vaccination Vaccine

SK Bioscience gains UK authorisation for SKYCovion Covid-19 vaccine

Pharmaceutical Technology

MAY 30, 2023

SK Bioscience has received marketing authorisation from the UK’s medicines and healthcare products regulatory agency (MHRA) for its Covid-19 vaccine, SKYCovion. The authorisation allows the distribution of the vaccine in Scotland, Wales and England.

Vaccination

Vaccination Vaccine Protein Medicine

Radical Vaccine Strategy Could Help Quash Parasite Afflicting Millions

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 11, 2024

Using viruses that infect bacteria to detect proteins sprouted by a notorious parasite, scientists have honed in on possible vaccine targets for schistosomiasis, a neglected tropical disease that currently affects an estimated 600 million people worldwide, causing 280,000 deaths per year.

Vaccination

Vaccination Vaccine Bacteria Protein

Brazil’s ANVISA approves Takeda’s dengue vaccine candidate Qdenga

Pharmaceutical Technology

MARCH 14, 2023

The National Health Surveillance Agency (ANVISA) in Brazil has granted approval for Takeda ’s dengue virus vaccine candidate, Qdenga (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003). The vaccine has received approval for preventing dengue disease in people aged four years to 60 years.

Vaccination

Vaccination Vaccine Clinical Trials Clinical Trials

Japan grants approval for CSL and Arcturus’ Covid-19 vaccine

Pharmaceutical Technology

NOVEMBER 29, 2023

Japan’s MHLW has approved CSL and Arcturus Therapeutics’ self-amplifying mRNA (sa-mRNA) Covid-19 vaccine, ARCT-154.

Vaccination

Vaccination Vaccine

Ghana becomes first country to approve Oxford’s malaria vaccine

Pharmaceutical Technology

APRIL 14, 2023

Ghana’s Food and Drug Authority (FDA) has approved R21/Matrix-M malaria vaccine in children aged 5 to 36 months, marking the first regulatory clearance for the University of Oxford-developed vaccine in any country in the world. Children between the ages of five and 36 months are at highest risk of death from malaria.

Vaccination

Vaccination Vaccine Manufacturing Containment

UK MHRA approves Takeda’s dengue vaccine Qdenga

Pharmaceutical Technology

FEBRUARY 7, 2023

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has granted marketing authorisation for Takeda ’s dengue virus vaccine candidate, Qdenga (Dengue Tetravalent Vaccine [Live, Attenuated]). The vaccine candidate has been approved for active immunisation against the infection in people from four years of age.

Vaccination

Vaccination Vaccine Genetics Trials

Micron Biomedical receives funds to produce needle-free vaccines

Pharmaceutical Technology

NOVEMBER 17, 2023

in funding from the Bill & Melinda Gates Foundation for the bulk manufacturing of needle-free vaccines. Micron Biomedical has received $23.6m

Vaccination

Vaccination Vaccine Manufacturing

Latest WHO Covid-19 vaccine guidance may decrease future demand

Pharmaceutical Technology

APRIL 3, 2023

The World Health Organisation (WHO) has revised its recommendations regarding the use of Covid-19 vaccines following a meeting of the agency’s Strategic Advisory Group of Experts on Immunisation (SAGE). The panel emphasised that the extra booster dose recommendation only pertains to one shot and is not for continued annual booster vaccines.

Vaccination

Vaccination Vaccine

China grants EUA to Covid-19 vaccine against XBB descendent lineages

Pharmaceutical Technology

JUNE 9, 2023

5+delta) protein vaccine (Sf9 cell). This marks the world’s first Covid-19 vaccine approved for emergency use against XBB descendent lineages of SARS-CoV-2. The vaccine has been developed by WestVac Biopharma along with the West China Medical Center and Sichuan University. recombinant Covid-19 trivalent (XBB.1.5+BA.5+delta)

Vaccination

Vaccination Vaccine HR Protein

‘Project NextGen’ picks new mRNA, intranasal COVID vaccines for funding

Bio Pharma Dive

OCTOBER 13, 2023

The awards, to biotechs Gritstone, Codagenix and CastleVax, are part of the program’s plan to develop vaccines with broader or longer-lasting benefits.

Vaccination

Vaccination Vaccine Development

Sanofi signs mRNA vaccine development deal with IDT Australia

Pharmaceutical Technology

APRIL 16, 2024

Sanofi has signed an agreement with IDT Australia for preclinical formulation development of its messenger RNA (mRNA) vaccines.

Vaccination

Vaccination Vaccine Development RNA

FDA fast tracks MimiVax’s glioblastoma vaccine SurVaxM

Pharmaceutical Technology

OCTOBER 13, 2023

The Phase IIb SurVaxM vaccine study will enrol 265 patients and has an estimated completion date in Q2 2024.

Vaccination

Vaccination Vaccine

FDA weighs shift in COVID vaccination strategy

Bio Pharma Dive

JANUARY 23, 2023

Agency scientists are proposing to update COVID shots once a year to match circulating coronavirus strains, as well as simplifying current vaccination regimens.

Vaccination

Vaccination Vaccine Scientist

Extreme Case of Man Who Had 217 COVID Vaccines Surprises Scientists

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 12, 2024

That’s how many vaccines a man in Germany claims to have received for COVID-19 in just 29 months – and his body isn’t reacting the way some scientists thought it would. Two hundred and seventeen. The 62-year-old male from the city of Magdeburg made headlines a few years ago for his private and risky decision […]

Scientist

Scientist Vaccination Vaccine Clinical Trials

HIV vaccines suffer setbacks but new approaches could turn the tide

Pharmaceutical Technology

FEBRUARY 3, 2023

Only a few weeks into the new year, the prospect of getting a successful advanced HIV vaccine shrank after the discontinuation of yet another late-stage trial. On January 18, Janssen, a Johnson & Johnson (J&J) subsidiary, stated that its vaccine was not effective in preventing HIV infections.

Vaccination

Vaccination Vaccine Antibody Trials

Novovax’s Omicron-targeting Covid-19 vaccine obtains WHO emergency listing

Pharmaceutical Technology

NOVEMBER 28, 2023

The emergency use listing is based on non-clinical data where the vaccine demonstrated immune responses against variants in SARS-CoV-2.

Immune Response

Immune Response Vaccination Vaccine

Pfizer begins plan to challenge Shingrix with an mRNA vaccine

Bio Pharma Dive

FEBRUARY 10, 2023

The pharma and partner BioNTech have kicked off the first human trial of a messenger RNA shot for shingles, believing there’s room to clear the high bar set by GSK’s rival vaccine.

Vaccination

Vaccination Vaccine RNA Trials

Novo Nordisk Foundation sets up airborne infection vaccine initiative

Pharmaceutical Technology

DECEMBER 18, 2023

The Novo Nordisk Foundation has invested Dkr1.8bn in the initiative to develop vaccines for various airborne infection diseases.

Vaccination

Vaccination Vaccine Development

England’s MMR vaccinations up 23% following NHS initiative

Pharmaceutical Technology

APRIL 5, 2024

Recent campaigns have targeted children and young adults in low vaccine uptake areas amidst a rising number of measles cases.

Vaccination

Vaccination Vaccine

Health Canada approves Novavax’s Covid-19 vaccine for adolescents

Pharmaceutical Technology

DECEMBER 7, 2022

Health Canada has granted approval for a supplement to a New Drug Submission (sNDS) of Novavax ’s Covid-19 vaccine (Recombinant protein, Adjuvanted), Nuvaxovid (NVX-CoV2373), for use in adolescents aged 12 to 17 years. The trial is designed to analyse the safety and effectiveness of the vaccine.

Vaccination

Vaccination Vaccine Protein Clinical Trials

US launches $5bn effort for new Covid-19 vaccines development

Pharmaceutical Technology

APRIL 11, 2023

The US government is reportedly investing more than $5bn in a programme to accelerate the development of new Covid-19 vaccines and treatments. Health experts have lent their support to the new programme as the existing vaccines may not be as effective against future virus threats.

Vaccination

Vaccination Vaccine Development Antibody

2023 in review: Cancer vaccines dose up on advances with tailored approaches

Pharmaceutical Technology

DECEMBER 22, 2023

As the number of patients with cancers continues to grow globally, research into personalised cancer vaccines is vital.

Vaccination

Vaccination Vaccine Research

GSK and Zhifei sign deal for shingles vaccine in China

Pharmaceutical Technology

OCTOBER 9, 2023

GSK and Chongqing Zhifei have signed an exclusive agreement for co-promoting the former’s shingles vaccine, Shingrix, in China.

Vaccination

Vaccination Vaccine

Gates Foundation announces $40m for mRNA vaccine platform

Pharmaceutical Technology

OCTOBER 10, 2023

The Gates Foundation is providing $40m in funding to advance the accessibility of Quantoom Biosciences' affordable mRNA vaccine platform.

Vaccination

Vaccination Vaccine

FDA approves Pfizer-BioNTech’s Omicron XBB.1.5-adapted Covid-19 vaccine

Pharmaceutical Technology

SEPTEMBER 12, 2023

adapted monovalent Covid-19 vaccine, COMIRNATY 2023-2024 Formulation. The US FDA has approved Pfizer and BioNTech’s sBLA for Omicron XBB.1.5-adapted

FDA Approval

FDA Approval Vaccination Vaccine