Scienmag

FEBRUARY 11, 2021

Credit: Karolinska Institutet Variants of nine genes increase the risk of developing Addison’s disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison’s disease. The findings help increase knowledge about what causes the disease.

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Gene Genetics Development Allergies 72

Scienmag

OCTOBER 26, 2020

Researchers at Yale University and the Broad Institute of MIT and Harvard screened hundreds of millions of cells exposed to the COVID-19 and MERS viruses and identified dozens of genes that both enable the viruses to replicate in cells and also those that seem to slam the door on the virus. The pro-viral and anti-viral […].

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Gene Research Gene Therapy Allergies 74

Scienmag

MAY 11, 2021

An international team of researchers at Great Ormond Street Hospital (GOSH), and University of California, Los Angeles (UCLA) have developed a gene therapy that successfully treated 48 out of 50 children with a form of severe combined immunodeficiency that leaves them without an immune system.

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Gene Therapy Gene Development Research 73

Delveinsight

AUGUST 6, 2020

Taysha raises USD 95 Million to take 4 CNS gene therapies into the clinic. Taysha Gene Therapies has raised USD 95 million to take four gene therapies into humans. FDA turns back peanut allergy patch of DBV Technologies. A peanut allergy patch which is based on new delivery technology has hit a snag at the FDA.

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Scienmag

APRIL 16, 2021

– April 16, 2021 – Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Credit: Dotted Yeti LA JOLLA, CALIF.

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Gene Scientist Research Allergies 60

The Pharma Data

AUGUST 24, 2020

The FDA has approved a request from American Gene Technologies to begin a clinical study into its HIV gene therapy. The treatment is being researched by scientists collaborating from American Gene Technologies, the Laboratory of Immunoregulation and the National Institute of Allergy and Infectious Diseases.

Gene Therapy 52

Gene Therapy Gene FDA Approval Trials 52

pharmaphorum

NOVEMBER 16, 2022

There’s plenty in the pipeline to entice a potential buyer, however, including several mid-stage clinical candidates, such as EPO inhibitor LKA651 for diabetic retinopathy, Factor B inhibitor iptacopan for AMD, and gene therapy PPY988 for geographic atrophy.

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Sales Gene Therapy Allergies Medicine 124

Scienmag

APRIL 2, 2021

FINDINGS A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule. This new approach to CAR T gene therapy — a type of immunotherapy that […].

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Gene Therapy Gene Research Allergies 53

Scienmag

DECEMBER 21, 2020

LJI scientists track down control elements that govern gene expression from a distance Credit: Alex Fung LA JOLLA–The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease. “The difference is within us,” says Vivek Chandra, Ph.D.,

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Gene Expression Gene Genetics Scientist 52

Scienmag

OCTOBER 25, 2020

Jänne New results from early clinical trials of a drug that targets a cancer-causing mutation in the KRAS gene have shown that it can shrink tumours and is well-tolerated by patients. Latest results from KRYSTAL-1 early clinical trial of adagrasib (MRTX849) Credit: Pasi A.

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Gene Clinical Trials Clinical Trials Trials 53

Scienmag

DECEMBER 21, 2020

Researchers baffled by an infant’s rare encephalitis case unusual in children found unheard-of mutations and a new way to examine the ‘immunity gene’ Credit: Satoshi Okada An infant’s odd case of rare encephalitis not typically found in children led researchers to discover never before seen genetic mutations and a more accurate (..)

Gene 52

Gene Genetics Research Allergies 52

XTalks

NOVEMBER 6, 2020

The Burnaby, BC-based company developed the oral DNA-based vaccine using its proprietary bacTRL Gene Therapy Platform, which uses genetically modified bifidobacteria as carriers of genetic vaccine elements on a DNA plasmid. Related: Red Meat Allergy Test Gets FDA Clearance. “We BacTRL Gene Therapy Platform.

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Clinical Trials Clinical Trials Vaccination Vaccine 75

XTalks

JULY 26, 2021

The authors concluded that the relatively high levels of the bacteria enterococci indicated that food safety was a concern for these products due to potential infections, antibiotic resistance and gene transfer associated with the bacteria E. FDA Regulation.

Protein 98

Protein Contamination Allergies Bacteria 98

The Pharma Data

AUGUST 7, 2020

The governing body claims this proposal could have positive effects on mitigating burdensome requirements for gene therapy clinical trials in the future. In this light, Pharma IQ’s weekly round-up focuses on advancing therapies and clinical trials to combat Covid-19.

Clinical Trials 52

Clinical Trials Clinical Trials Gene Trials 52

Scienmag

JUNE 9, 2021

First study to show gene expression changes in divers with ‘the bends’ reveals key role of genes for inflammation and immunity For over a century, researchers have known about “the bends”, a serious condition affecting scuba divers. However, we still know relatively little about its physiological basis.

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Gene Expression Gene Doctors Doctor 75

Scienmag

AUGUST 4, 2020

Histone deacetylases (HDACs) are enzymes that help modulate gene expression by removing […].

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Gene Expression Gene Scientist Research 82

Olympian Clinical Research

JUNE 10, 2022

This condition occurs when a gene variation causes the skin to become dry and irritated. Food allergies. Food allergies. If you are experiencing any of the above symptoms, it is important to consult with your doctor or dermatologist for an accurate diagnosis. What Causes Atopic Dermatitis? Excessive sweating. Excessive sweating.

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Allergies Clinical Trials Clinical Trials Clinical Research 98

Scienmag

MARCH 2, 2021

Scientists map the degradation of antibiotic resistance gene mecA by common disinfectants to find ways to minimize the spread of resistance in waterbodies Credit: Environmental Science and Technology For nearly a century, improvement in human healthcare has depended heavily on the efficiency with which we can treat bacterial diseases.

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Gene Scientist Allergies Medicine 73

Scienmag

FEBRUARY 1, 2021

A long noncoding RNA regulates the expression of inflammatory genes and has a surprising effect on vulnerability to septic shock in mice Credit: Apple Vollmers When the body’s immune response to an infection gets out of control, the result can be sepsis, a life-threatening condition in which an overwhelming inflammatory response can lead rapidly (..)

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Immune Response RNA Gene Regulation 70

Scienmag

AUGUST 14, 2020

Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with a targeted therapy known as rucaparib Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with (..)

Clinical Trials 57

Clinical Trials Clinical Trials Gene Trials 57

pharmaphorum

SEPTEMBER 17, 2021

Havas Life Medicom, ARK and Pharmadoctor top the agency charts AstraZeneca, klarify and Novartis Gene Therapies top the pharma leader board. Among pharma companies and healthcare organisations, the top three companies, taking two Golds each, were AstraZeneca, klarify and Novartis Gene Therapies. Allergy Test n Treat Service.

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Gene Therapy Gene Allergies Life Science 52

Roots Analysis

MARCH 16, 2023

Messenger ribonucleic acid (mRNA) is a single-stranded molecule that is complementary to a gene’s DNA. Further, these can be used to activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes.

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Vaccination Vaccine DNA Protein 52

Scienmag

NOVEMBER 9, 2020

Study reveals a previously unknown function of a human gene Credit: Lorenzo Bonaguro A genetic disposition that plays a role in the development of the heart in the embryo also appears to play a key role in the human immune system. This is shown by a recent study led by the University of Bonn (Germany). […].

Genetics 56

Genetics Gene Development Allergies 56

Scienmag

MARCH 30, 2021

In vitro treatment of cells with these molecules reduced the expression of a gene that plays a key role in viral cell entry and a cytokine receptor.

In-Vitro 55

In-Vitro Gene Allergies Medicine 55

Scienmag

AUGUST 14, 2020

Finding could lead to genetic tests that identify infants at risk for the disease Credit: NIAID WHAT: New research supported by the National Institutes of Health delineates how two relatively common variations in a gene called KIF3A are responsible for an impaired skin barrier that allows increased water loss from the skin, promoting the development (..)

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Genetics Scientist Gene Development 52

Scienmag

NOVEMBER 18, 2020

“Framing race […].

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Gene Research Dermatology Scientist 52

pharmaphorum

NOVEMBER 30, 2022

Working in the allergy and autoimmune space, COUR looks at nanoparticles and allergens – such as peanut and coeliac (which he had experience with whilst at Takeda) – and infuses these into patients as a treatment so that the body accepts it because of the precise combination technology, patients forming a tolerance to the antigen.

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Life Science Pharma Companies Sales Marketing 98

Eye on FDA

AUGUST 27, 2023

The committee that had the sole negative recommendation was from the Gastrointestinal Drugs Advisory Committee which did not recommend approval for an NDA involving a treatment for pre-cirrhotic liver fibrosis due to NASH.

Drugs 78

Drugs Gene Therapy Allergies Medicine 78

Roots Analysis

AUGUST 31, 2023

According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly. Nutritional DNA testing helps in identifying foods that might lead to allergies or intolerance in an individual. Figure below presents an overview of nutrigenomics.

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Genome Genomics Genetics Gene 40

Delveinsight

AUGUST 27, 2020

The phase 1 study that is being run by the National Institute of Allergy and Infectious Diseases tests three dose levels of the vaccine, mRNA-1273, given in two injections a month apart in 120 adults. Moderna showed robust phase 1 results for its COVID-19 vaccine in adults up to 55 last month.

Vaccination 53

Vaccination Vaccine Research Trials 53

The Pharma Data

FEBRUARY 22, 2021

Gene editing investments advance agriculture with improved food quality, higher yield, and improved crop nutrition. Gene editing is the key to better solutions and greater choices for farmers and consumers around the world. In crop science that means a transformative opportunity to improve yield and simplify harvesting for farmers.

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Gene Editing Genome Genomics Protein 40

Scienmag

JUNE 20, 2021

Researchers shed light on a potential intervention that could make tumors responsive to modern-day immunotherapies Credit: Mei Huang, PhD BOSTON – Researchers from Massachusetts General Hospital (MGH) have discovered a biological mechanism that transforms cells exposed to carcinogens from environmental factors like smoking and ultraviolet light (..)

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Research Allergies Gene Genetics 98

Scienmag

JULY 14, 2021

Scientists report that the alternative-splicing regulator NSrp70 influences immune T cell development Credit: Gwangju Institute of Science & Technology T lymphocytes, or T cells, are immune cells with diverse roles in building the body’s immunity. How does one particular cell type fight against a host of different pathogens?

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Scientist Regulation Development Allergies 98

The Pharma Data

AUGUST 5, 2021

Bayer recently formed its own cell and gene therapy platform as part of its transformation strategy for Pharmaceuticals. Research and development expenses increased against the low prior-year figure and were partly attributable to the cell and gene therapy unit. and from a strong allergy season in North America, which resulted in a 15.8

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Sales Production Gene Therapy Allergies 52

Scienmag

DECEMBER 13, 2020

Credit: Kim Ratliff, AU photographer Cancer immunotherapy using “designer” immune cells has revolutionized cancer treatment in recent years.

Genetic Engineering 95

Genetic Engineering Engineer Genetics Allergies 95

Scienmag

OCTOBER 29, 2020

USF Health-led TEDDY analysis focuses on development of multiple distinct autoantibodies targeting insulin-producing cells, from initial autoimmunity to symptomatic type 1 diabetes Credit: Courtesy of USF Health TAMPA, Fla.

Genetics 92

Genetics Insulin Development Clinical Trials 92

Scienmag

MARCH 29, 2021

Credit: Photo by Cori Kogan, Washington State University Health Sciences Spokane SPOKANE, Wash.

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Protein Scientist Research Allergies 88