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New 3D maps reveal inner workings of immune cell gene expression

Scienmag

LJI scientists track down control elements that govern gene expression from a distance Credit: Alex Fung LA JOLLA–The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease. “The difference is within us,” says Vivek Chandra, Ph.D.,

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Study: Enzyme could prove effective in treating tumors and inflammatory diseases in lung

Scienmag

Histone deacetylases (HDACs) are enzymes that help modulate gene expression by removing […].

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Molecular changes in white blood cells can help diagnose ‘the bends’ earlier in divers

Scienmag

First study to show gene expression changes in divers with ‘the bends’ reveals key role of genes for inflammation and immunity For over a century, researchers have known about “the bends”, a serious condition affecting scuba divers. However, we still know relatively little about its physiological basis.

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Symvivo’s Oral COVID-19 Vaccine Enters Clinical Trials

XTalks

The Burnaby, BC-based company developed the oral DNA-based vaccine using its proprietary bacTRL Gene Therapy Platform, which uses genetically modified bifidobacteria as carriers of genetic vaccine elements on a DNA plasmid. Related: Red Meat Allergy Test Gets FDA Clearance. “We BacTRL Gene Therapy Platform.

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Nutrigenomics: The Future of Personalized Nutrition

Roots Analysis

According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly. Nutritional DNA testing helps in identifying foods that might lead to allergies or intolerance in an individual. Figure below presents an overview of nutrigenomics.

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Tezepelumab granted Priority Review by U.S. FDA

The Pharma Data

Ann Allergy Asthma Immunol. World Allergy Organization (WAO). EMJ Allergy Immunol. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. Explor Res Hypothesis Med. 2019;4:35-38. Tran TN, et al. 2016;116:37-42. Chung KF, et al. Eur Respir J.

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Tezepelumab NAVIGATOR Phase 3 Trial Met Primary Endpoint Of A Statistically Significant And Clinically Meaningful Reduction In Exacerbations In A Broad Population Of Patients With Severe Asthma

The Pharma Data

10 World Allergy Organization (WAO). EMJ Allergy Immunol. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. Asthma control and management in 8,000 European patients: the Recognise Asthma and Link to Symptoms and Experience (REALISE) survey.

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