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All 38 subjects who were evaluable for immunogenicity had balanced cellular and humoral immuneresponses following the second dose of INO-4800.
The antigen is processed naturally in the cell and triggers the desired T cell and antibody-mediated immuneresponses. It will be funded by the U.S.
But some patients develop resistance to current immunotherapies and others have cancers characterized by immunologically “cold” tumors, which evade or suppress the patient’s immuneresponse against his or her cancer. This agent was developed by one of the co-authors, Jamey Weichert, Ph.D.,
These companies include Moderna, a US biotech company which has formed a partnership with the National Institute of Allergy and Infectious Diseases (NIAID), Oxford University who has partnered with AstraZeneca, and Johnson & Johnson, Merck and Pfizer. China’s COVID-19 Vaccine: Sinovac Biotech and CanSino Biologics.
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