Allergies and Medicine - Clinical Research Informer

Roche’s Xolair is first medicine for food allergy in US

pharmaphorum

FEBRUARY 19, 2024

Fast approaching the end of its patent life, Roche and Novartis’ Xolair is going out with a bang, picking up a new approval as the first and only drug therapy for people with food allergies in the US.

Allergies

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FDA approves Roche, Novartis' Xolair to prevent severe outcomes from common food allergies

Fierce Pharma

FEBRUARY 16, 2024

People with food allergies finally have a drug that can help prevent severe outcomes—and it’s a drug that’s been on the market for two decades. People with food allergies finally have a drug that can help prevent severe outcomes—and it’s a drug that’s been on the market for two decades.

Allergies

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NICE backs Aimmune’s peanut allergy drug Palforzia for children

pharmaphorum

DECEMBER 23, 2021

Children in England with peanut allergies could be among the first in Europe to get access to Aimmune’s oral immunotherapy Palforzia, after the drugmaker agreed a supply deal with NHS England. billion last year, is also developing immunotherapies for other indications including egg and multi-tree nut allergies.

Allergies

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'Black sheep' of helper T cells may hold key to precision allergy treatment

Medical Xpress

MAY 3, 2023

A new Nature Immunology study led by University of Pittsburgh and National Institutes of Health researchers sheds light on how a rare type of helper T cell, called Th9, can drive allergic disease, suggesting new precision medicine approaches to treating allergies in patients with high levels of Th9.

Allergies

Allergies Medicine Research

90% of penicillin allergy labels in Hong Kong found to be false

Medical Xpress

NOVEMBER 28, 2022

A collaborative research team led by Dr. Philip Li from the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has pioneered a new nurse-led penicillin allergy triage and testing strategy—the Hong Kong Drug Allergy Delabelling Initiative (HK-DADI), and demonstrated its effectiveness and safety compared to traditional allergy testing.

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Don't let food allergies spoil your child's fun

Medical Xpress

APRIL 4, 2023

Children with food allergies might experience heightened anxiety over social situations involving food. A Baylor College of Medicine psychologist explains how parents can alleviate this stress while teaching them to be mindful of their allergies.

Allergies

Allergies Medicine

Asthma Drug Xolair Wins FDA Approval as First Treatment for Multiple Food Allergies

XTalks

FEBRUARY 26, 2024

The class of IgE-mediated food allergies includes 160 foods, with peanuts, milk, eggs, wheat, soy and tree nuts being the most common ones. According to the Centers for Disease Control and Prevention (CDC), almost six percent of people in the US in 2021 had a food allergy. However, the treatment is restricted to peanut allergy.

Allergies

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RVAC and University of Pennsylvania to develop mRNA vaccines

Pharmaceutical Technology

MARCH 20, 2023

RVAC Medicines has announced a research collaboration with the University of Pennsylvania (Penn) for the discovery and development of mRNA vaccines. The partnership will focus on developing potential new vaccines to treat certain selected autoimmune indications, as well as food allergies.

Vaccine

Vaccine Vaccination Development Allergies

Black, Hispanic severe allergy patients less likely to receive allergy shots

Medical Xpress

APRIL 6, 2023

Black and Hispanic patients with severe allergies are less likely to get a common treatment, allergen immunotherapy, compared to white patients, according to Penn State College of Medicine researchers.

Allergies

Allergies Medicine Development Research

Re-examining antibodies' role in childhood allergies

Medical Xpress

DECEMBER 2, 2022

The presence of food-specific IgA antibodies in the gut does not prevent peanut or egg allergies from developing in children, according to a Northwestern Medicine study published in Science Translational Medicine.

Allergies

Allergies Antibody Medicine Development

Maternal Antibodies: How Allergies Can be Passed from Mothers to Children

XTalks

NOVEMBER 4, 2020

It has long been known that mothers greatly influence the development of the growing fetus by not only providing nutrients through the placenta, but also a growing list of biological elements including beneficial antibodies, gut bacteria and now, allergies. Related: Red Meat Allergy Test Gets FDA Clearance.

Allergies

Allergies Antibody In-Vitro Development

Coronavirus vaccine may have allergy warning in US, says expert

pharmaphorum

DECEMBER 10, 2020

Moncef Slaoui, co-head of the US government’s Operation Warp Speed COVID-19 vaccine programme, made the comments after the UK drugs regulator advised those with severe allergies to avoid the vaccine. The post Coronavirus vaccine may have allergy warning in US, says expert appeared first on.

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Allergies Vaccine Vaccination Regulation

COVID-19 vaccines and allergies: Updated advice needs to reach a wider audience, says BMJ

BioPharma Reporter

JANUARY 18, 2021

At the end of December, the UK's Medicines and Healthcare products Regulatory Agency (MHRA) updated its advice on the Pfizer/BioNTech vaccine: saying that those with unrelated allergies could receive it. But this announcement did not receive as much coverage as the MHRAâs earlier pause on vaccination in people with allergies.

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Allergies Vaccine Vaccination Medicine

Ready, Set, Food! Receives $3.5 Million to Help Parents Fight the Food Allergy Epidemic

XTalks

JUNE 21, 2021

who is on a mission to help parents save their children from food allergies by providing them with a powder added to their milk bottles. Zakowski started this company because his nephew developed several severe food allergies. Related: Red Meat Allergy Test Gets FDA Clearance. The product is part of a three-step guidance system.

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Food allergies, changes to infant gut bacteria linked to method of childbirth, ethnicity

Scienmag

APRIL 20, 2021

Babies born by caesarean section to mothers of Asian descent are eight times more likely to develop peanut allergy by age three, study shows Credit: Faculty of Medicine & Dentistry, University of Alberta Researchers have found a causal link between caesarean section birth, low intestinal microbiota and peanut sensitivity in infants, and they report (..)

Allergies

Allergies Bacteria Medicine Development

Food allergies leave parents living in fear

Scienmag

MARCH 10, 2021

Parents of children with food allergies face significant worry, severe anxiety and post-traumatic stress – according to new research from the University of East Anglia. Between six and eight per cent of children suffer a food allergy – with eggs, milk, and peanuts being the most common causes.

Allergies

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Tiny molecules in breast milk may protect infants from developing allergies

Medical Xpress

NOVEMBER 15, 2022

Breastfed babies are believed to suffer fewer allergic conditions, like eczema and food allergies, than formula-fed babies; yet the reason has not been well understood.

Allergies

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Tackling food allergies at the source

Scienmag

NOVEMBER 17, 2020

Credit: Eliot Herman Food allergies are a big problem. suffer from some kind of food allergy. These allergies cost a whopping $25 billion in health care each year. About 7% of children and 2% of adults in the U.S. Then there’s the time lost at school or work.

Allergies

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Oral immunotherapy induces remission of peanut allergy in some young children

Scienmag

JANUARY 20, 2022

A clinical trial funded by the National Institutes of Health has found that giving peanut oral immunotherapy to highly peanut-allergic children ages 1 to 3 years safely desensitized most of them to peanut and induced remission of peanut allergy in one-fifth. The immunotherapy consisted of a daily oral dose of peanut flour for 2.5

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Novel peanut allergy treatment shown to be safe, effective and lasting

Medical Xpress

FEBRUARY 28, 2023

A four-year clinical trial led by Edwin Kim, MD, at the UNC School of Medicine, has found that an increased dosage of a unique type of peanut allergy immunotherapy continues to show promise for children.

Allergies

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An allergy drug showed promise for MS, but could they prove it?

Medical Xpress

FEBRUARY 16, 2023

What if an over-the-counter allergy medicine could help halt and even reverse multiple sclerosis? And if it did, could patients return to their full capacity? Those were some of the questions first posed in 2013 after a landmark discovery by UC San Francisco neuroscientist Jonah Chan, Ph.D., and physician-scientist Ari Green, MD.

Allergies

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EU bans cough syrup chemical over severe allergies

Medical Xpress

DECEMBER 2, 2022

Cough medicines containing the chemical pholcodine should be banned due to the risk of potentially deadly allergic reactions in people under general anaesthetic, the European Union's drug regulator said Friday.

Allergies

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Pfizer inks another EpiPen antitrust settlement, this one worth $50M

Fierce Pharma

OCTOBER 11, 2023

Pfizer has agreed to pay $50 million to resolve a class-action, antitrust case which alleged the company teamed up with others to delay the entry of a generic version of the EpiPen allergy relief m | Pfizer has agreed to pay $50 million to resolve a class-action, antitrust case which alleged the company teamed up with others to delay the entry of a (..)

Allergies

Allergies Medicine

Denied by AI: How Medicare Advantage plans use algorithms to cut off care for seniors in need

STAT News

MARCH 13, 2023

An algorithm, not a doctor, predicted a rapid recovery for Frances Walter, an 85-year-old Wisconsin woman with a shattered left shoulder and an allergy to pain medicine. days, it estimated, she would be ready to leave her nursing home.

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Efficacy of an Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge

JAMA Internal Medicine

JULY 16, 2023

This randomized clinical trial aims to determine whether a direct oral penicillin challenge is noninferior to the standard of care of penicillin skin testing followed by an oral challenge in patients with a low-risk penicillin allergy.

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Merck gives taxpayers the middle finger

World of DTC Marketing

OCTOBER 6, 2021

government $712 for the same amount of medicine or 40 times the price. Like the vast majority of medicines on the market, molnupiravir — which was originally investigated as a possible treatment for Venezuelan equine encephalitis — was developed using government funds. And while it costs $17.74 Merck charges the U.S. The Intercept.

Clinical Trials

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Gene variants help explain connection between skin disorder and food allergy risk

Scienmag

AUGUST 14, 2020

Discovery could lead to new screening tests and potential treatments Credit: Cincinnati Children’s Two common variants in the KIF3A gene increase the risk of young children having a dysfunctional skin barrier and developing the skin condition atopic dermatitis.

Allergies

Allergies Gene Development Dermatology

‘Fortunate accident’ may yield immunity weapon against antibiotic-resistant bacteria

Scienmag

JULY 7, 2021

Johns Hopkins Medicine study uncovers enzyme inhibitor that boosts immune system to fight MRSA and other dangerous skin infections Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health FOR IMMEDIATE RELEASE In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander (..)

Bacteria

Bacteria Allergies Medicine Dermatology

University of Alberta virologist awarded Nobel Prize in Physiology or Medicine

Scienmag

OCTOBER 5, 2020

Michael Houghton discovered hepatitis C virus and now is developing a vaccine Credit: Photo: Michael Holly Michael Houghton was awarded the 2020 Nobel Prize in Physiology or Medicine today in recognition of his discovery of the hepatitis C (HCV) virus.

Medicine

Medicine Vaccine Vaccination Development

Antibody treatment improves chronic food allergy symptoms in young adults, study finds

Medical Xpress

DECEMBER 22, 2022

A weekly dose of dupilumab, a monoclonal antibody, led to a reduction of symptoms and tissue improvement in young adults and adolescents with eosinophilic esophagitis (EoE), according to a new study published in the New England Journal of Medicine.

Antibody

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Published Phase I Results Hint at Durability of Moderna's COVID-19 Vaccine

BioSpace

DECEMBER 4, 2020

National Institutes of Allergy and Infectious Diseases (NIAID) published a letter in The New England Journal of Medicine describing the three-month immunogenicity levels in Moderna’s mRNA-1273 vaccine. Researchers with the U.S.

Vaccine

Vaccine Vaccination Allergies Medicine

Reducing lung transplant rejection aim of clinical trial funded with $22 million grant

Scienmag

NOVEMBER 18, 2021

Physicians at Washington University School of Medicine in St.

Clinical Trials

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Elastic-free face masks can help some with allergies stay safe during COVID-19

Scienmag

NOVEMBER 13, 2020

University of Cincinnati fellow presents case related to COVID-19 during national meeting Credit: Colleen Kelley/University of Cincinnati A University of Cincinnati immunologist is recommending that individuals with contact dermatitis choose facial masks made without elastic or rubber that allow them to stay safe in the midst of COVID-19 while avoiding (..)

Allergies

Allergies Dermatology Medicine

Novel coronavirus circulated undetected months before first COVID-19 cases in Wuhan, China

Scienmag

MARCH 18, 2021

Study dates emergence to as early as October 2019; simulations suggest in most cases zoonotic viruses die out naturally before causing a pandemic Credit: National Institute of Allergy and Infectious Diseases Using molecular dating tools and epidemiological simulations, researchers at University of California San Diego School of Medicine, with colleagues (..)

Allergies

Allergies Medicine Research

November 29, 2022: INSPIRE Demonstration Project Joins the NIH Pragmatic Trials Collaboratory

Rethinking Clinical Trials

NOVEMBER 29, 2022

Gohil is an assistant professor of medicine at the University of California, Irvine, and associate medical director of epidemiology and infection prevention at UCI Health. Richard Platt, professor and chair of population medicine at the Harvard Pilgrim Health Care Institute, are the co–principal investigators for the project.

Trials

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Infant antibiotic exposure can affect future immune responses toward allergies

Scienmag

APRIL 1, 2021

Early life exposure to antibotics in utero and through mother’s milk disrupts beneficial gut bacteria, compromising T-cell development, Rutgers research shows Exposure to antibiotics in utero and infancy can lead to an irreversible loss of regulatory T-cells in the colon-a valuable component of the immune system’s response toward allergens (..)

Immune Response

Immune Response Allergies Bacteria Development

HIV vaccines suffer setbacks but new approaches could turn the tide

Pharmaceutical Technology

FEBRUARY 3, 2023

The Janssen vaccines studied in the Imbokodo and Mosaico studies were based on the mosaic concept, where they were intentionally designed to include a broader immunogen that could be used everywhere, says Dr. Mary Marovich, director of the Vaccine Research Program at National Institute of Allergy and Infectious Diseases (NIAID).

Vaccine

Vaccine Vaccination Antibody Trials

Rensselaer team receives NIAID grant to develop antiviral drug for Covid-19

Pharmaceutical Technology

JUNE 28, 2022

grant from the National Institutes of Health (NIH) unit National Institute of Allergy and Infectious Diseases (NIAID) for developing a Covid-19 oral antiviral drug. The Rensselaer team will partner with researchers from the Scripps Research Institute, Mount Sinai School of Medicine and the University of Bologna, Italy for this research.

Development

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Scripps Research awarded $67 million by NIH to lead new Pandemic Preparedness Center

Scienmag

MAY 18, 2022

LA JOLLA, CA—The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), is sponsoring a major new antiviral drug development center that will be led by Scripps Research.

Allergies

Allergies Research Development Drugs

MHRA warns of serious eye-related adverse events after Dupixent use

Pharmaceutical Technology

DECEMBER 7, 2022

On 29 November, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) warned of some new and potentially serious eye-related side effects associated with Dupixent, an interleukin (IL)-4/13 inhibitor drug used in the treatment of numerous allergic indications such as atopic dermatitis, asthma and nasal polyps.

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Review underscores links between climate change and nose and sinus conditions

Medical Xpress

FEBRUARY 7, 2023

In a new review article, Johns Hopkins Medicine experts and collaborators across the U.S. emphasize that climate change—particularly global warming—is contributing to an increase in the rates and to greater severity of nasal and sinus diseases, such as seasonal allergies—conditions that affect 2 billion people worldwide.

Allergies

Allergies Medicine

Novartis said to be eyeing sale of ophthalmology, respiratory units

pharmaphorum

NOVEMBER 16, 2022

Novartis has already spun out its eyecare business Alcon, and is now considering the sale of its ophthalmology and respiratory medicines businesses as it continues a narrowing of its focus, according to media reports.

Sales

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NIH awards grants to support bacteriophage therapy research

Scienmag

MARCH 11, 2021

“Phage” therapies offer potential strategy to combat antibacterial resistance Credit: NIAID The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded $2.5 million in grants to 12 institutes around the world to support research on bacteriophage therapy.

Research

Research Allergies Medicine

No drugs for prions: could new approaches alleviate therapeutic scarcity?

Pharmaceutical Technology

AUGUST 5, 2022

It is ultra-rare,” says Jesús Rodriguez Requena, PhD, associate professor in the Department of Medicine at the University of Santiago de Compostela. There is an enormous emphasis on prion protein and prion protein folding,” says Dr. Laura Manuelidis, professor of neuropathology at the Yale School of Medicine. “If

Drugs

Drugs Protein Vaccine Vaccination

Roche’s Xolair is first medicine for food allergy in US

FDA approves Roche, Novartis' Xolair to prevent severe outcomes from common food allergies

Trending Sources

NICE backs Aimmune’s peanut allergy drug Palforzia for children

'Black sheep' of helper T cells may hold key to precision allergy treatment

90% of penicillin allergy labels in Hong Kong found to be false

Don't let food allergies spoil your child's fun

Asthma Drug Xolair Wins FDA Approval as First Treatment for Multiple Food Allergies

RVAC and University of Pennsylvania to develop mRNA vaccines

Black, Hispanic severe allergy patients less likely to receive allergy shots

Re-examining antibodies' role in childhood allergies

Maternal Antibodies: How Allergies Can be Passed from Mothers to Children

Coronavirus vaccine may have allergy warning in US, says expert

COVID-19 vaccines and allergies: Updated advice needs to reach a wider audience, says BMJ

Ready, Set, Food! Receives $3.5 Million to Help Parents Fight the Food Allergy Epidemic

Food allergies, changes to infant gut bacteria linked to method of childbirth, ethnicity

Food allergies leave parents living in fear

Tiny molecules in breast milk may protect infants from developing allergies

Tackling food allergies at the source

Oral immunotherapy induces remission of peanut allergy in some young children

Novel peanut allergy treatment shown to be safe, effective and lasting

An allergy drug showed promise for MS, but could they prove it?

EU bans cough syrup chemical over severe allergies

Pfizer inks another EpiPen antitrust settlement, this one worth $50M

Denied by AI: How Medicare Advantage plans use algorithms to cut off care for seniors in need

Efficacy of an Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge

Merck gives taxpayers the middle finger

Gene variants help explain connection between skin disorder and food allergy risk

‘Fortunate accident’ may yield immunity weapon against antibiotic-resistant bacteria

University of Alberta virologist awarded Nobel Prize in Physiology or Medicine

Antibody treatment improves chronic food allergy symptoms in young adults, study finds

Published Phase I Results Hint at Durability of Moderna's COVID-19 Vaccine

Reducing lung transplant rejection aim of clinical trial funded with $22 million grant

Elastic-free face masks can help some with allergies stay safe during COVID-19

Novel coronavirus circulated undetected months before first COVID-19 cases in Wuhan, China

November 29, 2022: INSPIRE Demonstration Project Joins the NIH Pragmatic Trials Collaboratory

Infant antibiotic exposure can affect future immune responses toward allergies

HIV vaccines suffer setbacks but new approaches could turn the tide

Rensselaer team receives NIAID grant to develop antiviral drug for Covid-19

Scripps Research awarded $67 million by NIH to lead new Pandemic Preparedness Center

MHRA warns of serious eye-related adverse events after Dupixent use

Review underscores links between climate change and nose and sinus conditions

Novartis said to be eyeing sale of ophthalmology, respiratory units

NIH awards grants to support bacteriophage therapy research

No drugs for prions: could new approaches alleviate therapeutic scarcity?

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