XTalks

JULY 25, 2023

The bacteria usually enter the body through wounds, but infection can also occur through contaminated meat or inhalation of spores. Cyfendus functions by stimulating the production of antibodies targeted against the protective antigen protein. Anthrax is a rare, yet severe disease caused by the bacterium B. Overall, 66.3

FDA Approval 98

FDA Approval Vaccination Vaccine Antibody 98

XTalks

AUGUST 2, 2022

Benlysta (belimumab) is a biologic therapy, a human monoclonal antibody. Autoreactive B cells release antibodies like other B cells do, except they release autoantibodies. The autoantibodies do not fight actual infection or bacteria, but rather the normal tissue in the body. How Benlysta (belimumab) Works.

FDA Approval 94

FDA Approval Antibody Bacteria Protein 94

pharmaphorum

JULY 14, 2021

Last year, Pfizer made almost $6 billion from its Prevnar 13 vaccine, which covers 13 common serotypes of Streptococcus pneumoniae – a bacteria which causes non-invasive illnesses like pneumonia, sinusitis and middle ear infections, as well as invasive diseases like meningitis. That is equivalent to 14% of Pfizer’s total revenues.

Immune Response 52

Immune Response Vaccination Vaccine Protein 52

pharmaphorum

AUGUST 7, 2020

LRRK2 regulates lysosomes, which play a vital role in cell function by breaking down excess or worn-out cell parts, and can also destroy invading viruses and bacteria. Mutations in the LRRK2 gene can cause Parkinson’s disease.

Bacteria 69

Bacteria Marketing Licensing Licensing 69

The Pharma Data

MARCH 8, 2021

This investigational multivalent protein subunit vaccine targets the outer surface protein A (OspA) of Borrelia, an established mechanism of action for a Lyme disease vaccine. OspA is one of the most dominant surface proteins expressed by the bacteria when present in a tick. burgdorferi naïve volunteers.

Vaccination 52

Vaccination Vaccine Bacteria Protein 52

Roots Analysis

OCTOBER 16, 2023

Biopharmaceutical filtration is a critical step in the production of biopharmaceuticals, including proteins, antibodies, and vaccines. Membrane Filters: Membrane filters are typically used for sterilization and removal of smaller impurities such as bacteria and viruses.

Bacteria 40

Bacteria Production Protein Contamination 40

pharmaphorum

MAY 31, 2022

Last year, Affinivax reported positive phase 2 results with ASP3772, which targets 24 of the common serotypes of Streptococcus pneumoniae – a bacteria which causes non-invasive illnesses like pneumonia, sinusitis and middle ear infections, as well as invasive diseases like meningitis. GSK said it is paying $2.1

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Vaccination Vaccine Bacterium Sales 52

The Pharma Data

MARCH 13, 2022

CD8+ T cells are nicknamed killer T cells (they’re also known as cytotoxic T cells) for their ability to eliminate foreign invaders such as bacteria and viruses from the body. “We only found one low-prevalence epitope from the omicron spike protein that had a minor change from its predecessor in the original virus,” says Redd.

Immune Response 52

Immune Response Protein Medicine Genetics 52

The Pharma Data

APRIL 22, 2023

Plasma cells produce antibodies that protect the body from invasive foreign substances, such as bacteria and viruses. When transforming into cancerous myeloma cells, however, plasma cells continue to produce monoclonal immunoglobulin (M protein) that is not capable of attacking the foreign substances.

Antibody 40

Antibody Protein Bacteria Drugs 40

The Pharma Data

APRIL 26, 2022

This investigational multivalent protein subunit vaccine uses an established mechanism of action for a Lyme disease vaccine that targets the outer surface protein A (OspA) of Borrelia burgdorferi, the bacteria that cause Lyme disease. About VLA15 VLA15 is the only Lyme disease vaccine candidate currently in clinical development.

Vaccination 52

Vaccination Vaccine Bacteria Protein 52

The Pharma Data

JULY 21, 2021

This investigational multivalent protein subunit vaccine uses an established mechanism of action for a Lyme disease vaccine that targets the outer surface protein A (OspA) of Borrelia burgdorferi , the bacteria that cause Lyme disease. VLA15 is tested as an alum-adjuvanted formulation and administered intramuscularly.

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Vaccination Vaccine Trials Bacteria 52

XTalks

JANUARY 20, 2021

To test their hypothesis in the lab, the researchers infected mice with a stomach bacterium and fed them a protein found in egg white called ovalbumin at the same time (this protein is commonly used as a typical model food antigen in experiments). Moreover, the response did not induce symptoms typical of a food allergy.

Immune Response 52

Immune Response Research Allergies Protein 52

The Pharma Data

JUNE 30, 2021

In our study, we measured the humoral response – so the level of antibodies – in naturally exposed cats,” relays Yasmin Parr. To achieve this, she developed a novel ELISA (Enzyme-linked Immunosorbent Assay) to measure a certain antibody type directed towards a specific protein of the virus.

Scientist 52

Scientist Immune Response Antibody Development 52

Pfizer

FEBRUARY 16, 2023

This investigational multivalent protein subunit vaccine uses an established mechanism of action for a Lyme disease vaccine that targets the outer surface protein A (OspA) of Borrelia burgdorferi, the bacteria that cause Lyme disease. OspA is a surface protein expressed by the bacteria when present in a tick.

Clinical Trials 76

Clinical Trials Clinical Trials Vaccination Vaccine 76

The Pharma Data

OCTOBER 26, 2020

AR-711 is a fully human immunoglobulin 1, or IgG1, monoclonal antibody discovered from screening the antibody secreting B-cells of convalescent COVID-19 patients. AR-711 exhibits high affinity for SARS-CoV-2 spike protein, approximately 10-fold or higher than mAb candidates currently in late stage clinical testing. About AR-711.

Antibody 52

Antibody Genetic Engineering Development Clinical Trials 52

pharmaphorum

OCTOBER 27, 2021

There was bad news for Lilly elsewhere is its Alzheimer’s pipeline as it announced the demise of anti-tau protein antibody zagotenemab, which had reached phase 2 but failed to have an impact on its primary endpoint. Cortexyme trial disappoints.

Trials 52

Trials Drugs Sales Bacteria 52

The Pharma Data

DECEMBER 15, 2020

On top of this, another 8 million carry auto-antibodies, blood molecules that indicate a person’s chance of developing an autoimmune disease. Scientists will be testing a drug class targeting the C-reactive protein (CRP) marker of acute inflammation in the body. Monoclonal Antibodies.

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Clinical Trials Clinical Trials Antibody Trials 52

The Pharma Data

OCTOBER 19, 2020

Diagnostics Update : To-date the FDA has authorized 282 individual EUAs, which include 220 molecular tests, 56 antibody tests and 6 antigen tests. . In a challenge trial, people are given a vaccine then intentionally dosed with the virus or bacteria that causes the disease. Diagnostics. Please read more here. . Other Industry News.

Vaccination 52

Vaccination Vaccine Trials Clinical Trials 52

XTalks

APRIL 12, 2021

synuclein is a hallmark of Parkinson’s, and it’s been postulated that dysfunction of GCase in neurons could contribute to build-up of the protein and the resulting inflammation and neurodegeneration characteristic of the disorder. According to the company’s pipeline page, the antibody drug is still in the drug discovery stage of development.

Gene Therapy 96

Gene Therapy Gene Trials Development 96

XTalks

DECEMBER 17, 2021

While researchers are still learning more about Omicron, what we know is that it has the ability to spread quickly, has over 30 mutations in its spike protein and can impact the effectiveness of current vaccines.

Life Science 98

Life Science Vaccination Vaccine Trials 98

The Pharma Data

SEPTEMBER 8, 2021

Related Peptide Monoclonal Antibody Therapy Added to OnabotulinumtoxinA Treatment. Real-World Evidence for the Safety and Efficacy of CGRP Monoclonal Antibody Therapy Added to OnabotulinumtoxinA Treatment for Migraine Prevention in Adult Patients with Chronic Migraine. September 8, 2021. BOTOX ® (onabotulinumtoxinA).

Botox 52

Botox Doctors Doctor Medicine 52

XTalks

AUGUST 2, 2023

Johnson & Johnson’s Top 5 Best-Selling Drugs of 2022: 1) Stelara (ustekinumab) Stelara is an immunosuppressant biologic therapy that blocks the IL-12 and IL-23 proteins that play a role in plaque psoriasis and Crohn’s disease. The monoclonal antibody targets CD20, a protein found on the surface of B lymphocytes (B cells).

Sales 98

Sales Manufacturing FDA Approval Life Science 98

pharmaphorum

SEPTEMBER 28, 2021

New phase 2 data with their VLA15 vaccine shows that antibody responses from an initial three-dose regimen are initially high, although they start to decline after 18 months in adult subjects.

Vaccination 105

Vaccination Vaccine Bacteria Protein 105

The Pharma Data

OCTOBER 14, 2020

VBL Therapeutics – The European Patent Office granted a patent to Israel-based VBL’s proprietary investigational anti-MOSPD2 monoclonal antibodies to treat inflammatory conditions. The highly potent and selective payload series represents a powerful new class within ADC development with novel protein alkylating cytotoxicity.

Clinical Trials 52

Clinical Trials Clinical Trials Manufacturing In-Vivo 52

pharmaphorum

DECEMBER 15, 2020

MinervaX’s protein-only GBS vaccine targets pregnant women for the prevention of adverse pregnancy outcomes and life-threatening neonatal infections associated with GBS. Phase 1 data from 300 healthy females have so far shown a favourable safety profile, while generating high levels of long-lasting antibodies.

Bacteria 52

Bacteria Vaccination Vaccine Immune Response 52

Delveinsight

DECEMBER 2, 2020

Even after several years of research, exact causes of Rheumatoid Arthritis are unknown, but some factors are believed that trigger the immune system to mistakenly send antibodies to attack the joints and the tissues surrounding them; which in turn results in pain and inflammation. These antibodies are signs of hyperactive immunity.

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Marketing Hormones Antibody Development 60

The Pharma Data

JANUARY 21, 2021

Doctors need better tools to evaluate the status of COVID-19 patients as early as possible because many of the treatments—such as monoclonal antibodies—are in short supply, and we know that some patients will get better without intensive treatments,” said co-senior author Andrew E. The research was published in the journal JCI Insight.

Research 52

Research DNA Hormones Vaccination 52

The Pharma Data

OCTOBER 19, 2020

Results from both studies are based on opsonophagocytic activity (OPA) responses – a measure of vaccine-induced functional antibodies. There are more than 90 different types of pneumococcal bacteria which can affect adults differently than children. Food and Drug Administration before the end of the year, remain on track.

Vaccination 52

Vaccination Vaccine Immune Response Containment 52

XTalks

DECEMBER 24, 2020

SARS-CoV-2 is characterized by an outer surface speckled with spike proteins, giving it a crown-like appearance, hence the name “corona,” which is the Latin word for crown. The spike protein is critical for binding to ACE2 receptors on host cells — this interaction mediates the entry of the virus into cells. Drug Approvals.

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Life Science Vaccination Vaccine Gene 111

XTalks

OCTOBER 14, 2022

Whooping cough , also known as pertussis, is a highly contagious respiratory infection caused by the Bordetella pertussis bacteria. Register for this free webinar to learn about total protein analysis, and quality control of vaccines and other protein-based therapeutics by total nitrogen determination.

FDA Approval 98

FDA Approval Vaccination Vaccine Protein 98

XTalks

FEBRUARY 4, 2021

The air of a hospital is not so clean and contains bacteria.”. Dr. Durand explains that the bacteria-laden air can cause bacteria to be deposited in the lungs, leading to pneumonia and then sepsis. For sepsis, a commercial immunoassay pancreatic stone protein (PSP) test is utilized.

Allergies 98

Allergies Bacteria Development Containment 98

Pharmaceutical Technology

MARCH 24, 2023

TB is caused by the bacillus Mycobacterium tuberculosis and is transmitted when infected individuals expel bacteria into the air (e.g., However, the vaccine is less effective in those who already have viral antibodies present in their blood, leaving out a large proportion of people. by coughing). million new cases reported worldwide.

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Vaccination Vaccine Trials Clinical Trials 162

Pharmaceutical Technology

MAY 17, 2023

In addition to revolutionising diabetes care, insulin has become an essential component of biopharmaceutical manufacturing, where its growth-supplementing ­­­properties are relied on to enhance commercially available cell culture media and achieve higher yields of target therapeutic proteins. Can it support the newer therapeutic modalities?

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Insulin Production Manufacturing Contamination 130

The Pharma Data

MAY 14, 2021

Charles River loses a battle over harvesting horseshoe crabs used for testing bacteria in drugs ( STAT ). Delayed second Pfizer COVID-19 shot produces more antibodies -study ( Reuters ). Delayed second Pfizer COVID-19 shot produces more antibodies -study ( Reuters ). Medtech.

Gene Therapy 52

Gene Therapy Gene Vaccination Vaccine 52