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Novartis taps immuno-oncology partner BeiGene for TIGIT drug

pharmaphorum

Novartis has joined the ranks of big pharma companies developing TIGIT-targeted drugs for cancer, and found its candidate in an existing partner, Chinese biotech BeiGene. Pharma companies are looking at whether blocking TIGIT as well as PD-1/PD-L1 can improve the efficacy of cancer immunotherapy.

Drugs 95
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Ambrx tries another IPO as it chases down HER2 rivals

pharmaphorum

California biotech Ambrx Biopharma is hoping to raise $126 million from a listing on the New York Stock Exchange (NYSE) that will be used in part to fund clinical development of ARX-788, its HER2-targeting antibody drug conjugate (ADC). billion upfront, when it licensed the ADC from Daiichi Sankyo in 2019.

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Enough Of Wasting Away From Cancer: Companies Gear Up To Tackle Cachexia

Delveinsight

The company has also signed a licensing agreement with Ono Pharmaceutical , a Japanese pharma company, transferring exclusive rights to develop and commercialise anamorelin in Japan, South Korea, and Taiwan. Cancer Cachexia Pipeline. Apart from the products as mentioned earlier, Tetra Bio?

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Unlocking T-cell receptor therapy for cancer

Drug Discovery World

In addition to BSB-1001, BlueSphere has also discovered and nominated three additional miHA-targeting TCRs for clinical development, all for use in the same clinical setting as BSB-1001. A few companies fully support cellular therapies, while others have consciously shied away.

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Taking a new approach to tackle neurodegenerative diseases

Drug Discovery World

Oligomerix’s portfolio of compounds is expected to provide a potentially lower-cost treatment alternative and/or complement to the newly emerging high-cost therapeutic options such as the monoclonal antibody products. Several of the large pharma companies have recently re-entered the dementia field. With its recent award of $3.35

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Are radiopharmaceuticals the next breakthrough in oncology?

pharmaphorum

It is a similar approach to that of another form of oncology treatment that is also experiencing a surge of interest, antibody-drug conjugates (ADCs). Big pharma has already noted its interest in the area, as seen in Novartis’ investments. The reason for the shutdown was due to potential discovery of quality issues at its plants.

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Drug discovery hotspots: What is the secret to Switzerland’s success? (p1)

Drug Discovery World

So, in this way there is a cross fertilisation from the bigger companies to newer ones. Start-ups will also take drug candidates from the pharma companies that are not getting attention for one reason or another and develop those into viable commercial products.” References [link] [link].