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Genentech’s ocular implant drugdeliverysystem for treatment of macular degeneration has received approval from the US Food and Drug Administration (FDA). Susvimo delivers ranibizumab via a port deliverysystem into a surgically placed implant in the eye, allowing for continuous delivery of the drug.
The US Food and Drug Administration (FDA) has approved Galderma’s monoclonal antibody Nemluvio (nemolizumab) for the treatment of adult patients with the chronic skin condition prurigo nodularis. Monoclonal antibody therapy has been found to have fewer side effects when compared to immunosuppressant drugs.
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Broad ClinicalTrial Landscape Till date, close to 800 clinical studies evaluating various liposome-based therapeutics have been initiated worldwide. Further, the most targeted disease area within oncological disorders is ovarian cancer, with 226 clinicaltrials registered in the given time period.
Therapies such as dexamethasone drugdeliverysystem and vascular endothelial growth factor inhibitors have already pierced deeper into the market. Brolucizumab is a humanized single-chain antibody fragment (scFv). The company has plans to initiate new trials for the product however not until the second half of 2021.
Since the approval of Soliris® in 2007, an anti-C5 antibody, the field of complement drug discovery has gained significant attention. Broad ClinicalTrial Landscape. Currently, nine complement therapeutics are commercially available, while around 190 molecules are under development for various disease indications.
Filipe Rodrigues, MD/MSc, Medical Director at Medpace spoke about the modern-day applications of direct CNS administration, including intrathecal, intraparenchymal and ICV delivery. Such therapies may involve small interfering RNA (siRNA) or oligonucleotides in viral transfection platforms, large molecules and antibodies. Figure 3 ).
S ites and Burden of Metastases and Long-Term Outcomes in TITAN Patients (moderated poster session) : Assessment of relationships between the number and location of metastases and oncological outcomes in 1,052 patients with metastatic castration-sensitive prostate cancer (mCSPC) enrolled in the TITAN trial (Abstract #MP24-08). About TAR-200.
The coupling of chemotherapeutic agents with LNPs leads to an increase in the drug levels in tumor tissue and decreases the active therapeutic dose, resistance of drugs and toxicity. The LNPs can be monitored using various imaging modalities to confirm the delivery of siRNA to the target cells.
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