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Ligand-targeted Liposomes: These liposomes can be employed for site- specific targeting by attaching ligands (including antibodies, peptides, and carbohydrates) to their surface or to the terminal end of the attached PEG chains. The figure highlights several parameters considered during liposome characterization.
However, certain biological targets have long eluded drug development efforts. Scientific literature suggests that the RAS gene is mutated across about 30% of cancer types. One such target is Ras family, which has been identified to play a critical role in oncogenesis.
Gene Therapies: LNPs have the ability to effectively deliver nucleic acids, including small interfering RNA (siRNA), messenger RNA (mRNA), and plasmid DNA to the target cells. In addition, these can be modified with ligands in order to improve the specificity and selectivity of the gene therapy and reduce off-target effects.
In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines and gene therapies), by the US FDA, have steadily risen. Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry. Our Social Media Platform.
We know that a lot of different pathologies, especially as we’ve entered the era of molecular medicine and gene therapies, cause many of the same symptoms and work through final common pathways. Such therapies may involve small interfering RNA (siRNA) or oligonucleotides in viral transfection platforms, large molecules and antibodies.
Therapies such as dexamethasone drugdeliverysystem and vascular endothelial growth factor inhibitors have already pierced deeper into the market. Brolucizumab is a humanized single-chain antibody fragment (scFv).
Genomics is the study of genetic material within a cell, and transcriptomics is the study of gene activity in different cells. Scientific fields involved in high throughput measurement of biological molecules are referred with the suffix- omics including, transcriptomics, genomics, proteomics and metabolomics. Our Social Media Platform.
Using nanomedicine to overcome drugdelivery barriers Apart from lipid nanoparticles, nanoparticle-related innovation is also reaching other types of drug development. Conde says the use of nanoparticle delivery for gene therapies has become more common over recent years.
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