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The authorization was based on trial data that showed the vaccine was safe, well-tolerated and induced robust immuneresponses among children in this age group; side effects were generally mild to moderate. Genentech’s New Ocular Implant DrugDeliverySystem for Macular Degeneration Could Be a Game Changer.
Since the approval of Soliris® in 2007, an anti-C5 antibody, the field of complement drug discovery has gained significant attention. The complement-targeted therapeutics inhibit complement activation, thereby reducing tissue inflammation and dampening the adaptive immuneresponse to foreign and tissue antigens.
Vaccines: LNPs have been increasingly used in vaccine development due to their ability to efficiently encapsulate and deliver antigens, that elicit a potent immuneresponse ( through antibody production and T-cells activation ). Further, they have been extensively utilized in the development of mRNA vaccines for COVID-19.
With early nanoparticle studies, researchers often found the human body’s innate immuneresponse to drugs and the short-lasting effects of drugs challenging, as they can also reduce a drug’s efficacy. This design protects antibodies from the innate immunesystem.
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