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Next Generation Complement Therapeutics: Potential Life-Changing Therapies for Multiple Rare Disorders

Roots Analysis

Since the approval of SolirisĀ® in 2007, an anti-C5 antibody, the field of complement drug discovery has gained significant attention. The complement-targeted therapeutics inhibit complement activation, thereby reducing tissue inflammation and dampening the adaptive immune response to foreign and tissue antigens.

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The Power of Lipids: Enhancing Drug Delivery with Nanoparticles

Roots Analysis

Vaccines: LNPs have been increasingly used in vaccine development due to their ability to efficiently encapsulate and deliver antigens, that elicit a potent immune response ( through antibody production and T-cells activation ). Further, they have been extensively utilized in the development of mRNA vaccines for COVID-19.

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Covid-19 vaccine success bolsters nanoparticle drug delivery research

Pharmaceutical Technology

With early nanoparticle studies, researchers often found the human bodyā€™s innate immune response to drugs and the short-lasting effects of drugs challenging, as they can also reduce a drugā€™s efficacy. This design protects antibodies from the innate immune system.