Remove Antibody Remove Gene Expression Remove In-Vivo Remove RNA
article thumbnail

Cell-penetrating peptides as a delivery system for oligonucleotides

Drug Discovery World

Oligonucleotides act on the RNA level through different molecular pathways, but there is a major drawback when using them as drugs: their poor bioavailability and cellular uptake. This is a common reaction within peptide chemistry and it has been approved by regulatory authorities for various antibody-drug conjugates 4. Anti-miRNA.

article thumbnail

Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

If you want to order gene-length sequences, rather than short oligos for PCR, the waiting times are around two or three weeks at least. Anita Ramanathan outlines four synthetic biology approaches that are improving and accelerating drug discovery. . This way, we can separate erroneous sequences from accurate ones.

DNA 98
article thumbnail

CRISPR breakthroughs: New solutions for common diseases

Drug Discovery World

Since its discovery in 2012, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has revolutionised the biomedicine and cell and gene therapy fields, providing a versatile tool for precise and efficient genome editing.

DNA 98