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Immune systems can be weakened in individuals with HIV/AIDS; cancer and transplant patients taking certain immunosuppressive drugs; and those with geneticdiseases affecting the immune system like congenital agammaglobulinemia and congenital IgA deficiency.
With early nanoparticle studies, researchers often found the human body’s innate immuneresponse to drugs and the short-lasting effects of drugs challenging, as they can also reduce a drug’s efficacy. This design protects antibodies from the innate immune system. These could feature in the next four to five years.
Shape’s RNA editing technology could potentially modify the amount of a key regulatory protein in the body or treat geneticdiseases. Researchers will compare the two-time points to recognize the optimum timing of peak immuneresponse following nasal vaccination. The study is set to conclude in the fall.
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Patients with this disease have a very high level of LDL-C, which increases their risk of coronary artery disease, including heart attack, stroke and atherosclerosis. The replacement therapy has been shown to improve metabolic complications and can also be used to treat the acquired form of the disease.
Vir Biotechnology and GlaxoSmithKline dosed the first patient in a new sub-trial of a Phase III study of monoclonal antibody VIR-7831 for hospitalized adults with COVID-19. The drug is a humanized IgG4 monoclonal antibody that blocks CCR5 and is being developed for COVID-19, HIV and metastatic triple-negative breast cancer.
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