pharmaphorum

JULY 18, 2022

It then elicits an immune response against that spike protein. You have a response with immunoglobulins type G (antibodies) and robust cellular response with both CD4 and CD8 T-cells being activated,” Morgon states. We get a higher immune response with the inhaled compared to the injectable,” Morgon relays.

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Vaccination Vaccine Development Immune Response 138

XTalks

AUGUST 8, 2022

Medicxi is a prominent international life sciences investment firm that invested in over 60 portfolio companies such as Versanis Bio, Rivus Pharmaceuticals, Capella Bioscience and more. One of Medicxi’s portfolio companies called MiroBio is set to be acquired by Gilead Sciences for approximately $405 million in cash.

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Immune Response Antibody Life Science Engineer 98

XTalks

JUNE 18, 2021

This is why Regeneron’s announcement of positive clinical trial results that show its antibody cocktail treatment can cut deaths among hospitalized patients is welcome news. It is the first trial to demonstrate that any antibody treatment could improve survival in patients hospitalized with COVID-19. Regeneron Pharmaceuticals Inc.’s

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Antibody Immune Response Trials Clinical Trials 75

XTalks

APRIL 1, 2025

About aGVHD aGVHD is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). It occurs when immune cells from the donor perceive the host tissues as foreign and subsequently initiate an immune response against them.

Immune Response 52

Immune Response Trials Licensing Licensing 52

XTalks

OCTOBER 12, 2021

The vaccine was tested in rats and showed strong, immediate and long-lasting immune responses to confer protection against the disease. is an autoantigen, which means it is an endogenous antigen that triggers an immune response in the body. antibodies in the knockout (KO) rats. With the finding that 14-3-3?

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Vaccination Vaccine Research Immune Response 105

XTalks

NOVEMBER 3, 2021

The authorization was based on trial data that showed the vaccine was safe, well-tolerated and induced robust immune responses among children in this age group; side effects were generally mild to moderate. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

Life Science 52

Life Science Drug Delivery Systems Vaccine Vaccination 52

XTalks

JANUARY 20, 2025

Pfizer announced promising results from its Phase III trial investigating the efficacy of sasanlimab, an anti-PD-1 monoclonal antibody, in combination with standard of care Bacillus Calmette-Guerin (BCG) immunotherapy for patients with high-risk non-muscle invasive bladder cancer (NMIBC) who are BCG-nave.

Antibody 52

Antibody Trials Clinical Trials Clinical Trials 52

XTalks

JANUARY 20, 2025

Pfizer announced promising results from its Phase III trial investigating the efficacy of sasanlimab, an anti-PD-1 monoclonal antibody, in combination with standard of care Bacillus Calmette-Guerin (BCG) immunotherapy for patients with high-risk non-muscle invasive bladder cancer (NMIBC) who are BCG-nave.

Antibody 52

Antibody Trials Clinical Trials Clinical Trials 52

XTalks

APRIL 7, 2021

As the COVID-19 pandemic shifts with new case surges largely owing to new variants of SARS-CoV-2, the US Food and Drug Administration (FDA) continues to offer up emergency use authorizations (EUA) for tests for the detection of COVID-19 infection, with the latest being antibody and antigen tests from Symbiotic and Quidel, respectively.

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Antibody Immune Response Radiology Marketing 102

XTalks

AUGUST 14, 2023

The Janssen Pharmaceutical Companies of Johnson & Johnson announced that its bispecific antibody Talvey (talquetamab-tgvs) received US Food and Drug Administration (FDA) approval as a fifth-line treatment for adult patients with heavily pretreated multiple myeloma. Results were similar at the higher 0.8 mg/kg dose with an ORR of 73.6

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FDA Approval Antibody Immune Response Drugs 97

XTalks

DECEMBER 14, 2021

Moderna revealed the first interim results from a small, Phase I study of its mRNA-based influenza vaccine, which showed that the vaccine had no significant safety concerns and elicited immune responses against four strains of the influenza virus. Antibody levels against the A strains were higher than the B subtypes.

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Vaccine Vaccination Immune Response Antibody 98

The Pharma Data

JANUARY 3, 2021

Patient reported outcome to assess clinical responses related to COVID-19 symptoms, as per the FDA guidelines, will also be collected. About Tiziana Life Sciences. Foralumab is the only fully human anti-CD3 monoclonal antibody (mAb) in clinical development in the world. . NEW YORK and LONDON, Jan.

Life Science 40

Life Science Clinical Trials Clinical Trials Antibody 40

Pharmaceutical Technology

APRIL 18, 2023

Adeno-associated virus vectors, alcohol dehydrogenase compositions, and antibody serum stabilisers are some of the accelerating innovation areas, where adoption has been steadily increasing. Among maturing innovation areas are anti-influenza antibody compositions and anti-interleukin-1, which are now well established in the industry.

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Protein Vaccination Vaccine Production 147

The Pharma Data

NOVEMBER 10, 2020

First Ever Study with take-home capsules of Foralumab , a Fully Human Anti-CD3 Monoclonal Antibody. Weiner, chairman of the scientific advisory board of Tiziana Life Sciences, commented: “We understand that this will be the first-ever study with ‘take-home’ capsules of any mAb for immunotherapies for human diseases.

Life Science 40

Life Science Clinical Trials Clinical Trials Trials 40

XTalks

AUGUST 16, 2021

Immune systems can be weakened in individuals with HIV/AIDS; cancer and transplant patients taking certain immunosuppressive drugs; and those with genetic diseases affecting the immune system like congenital agammaglobulinemia and congenital IgA deficiency. Related: CDC Backs J&J COVID-19 Shot Amid GBS and Delta Variant Concerns.

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Vaccine Vaccination Antibody Immune Response 104

pharmaphorum

JULY 20, 2021

According to some studies, beta may be the most likely to evade immune responses stimulated by the currently available shots as well as some antibody drugs for SARS-CoV-2, and is also thought to be more transmissible. 1.351) variant first identified in South Africa.

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XTalks

APRIL 26, 2021

Moreover, a very strong immune response is needed to fend off the disease. The vaccine is protein-based and contains an adjuvant (MM), a component that helps generate a stronger immune response, that was developed by Novavax. Malaria Vaccine Phase II Trial. At six months, 29.5

Vaccine 105

Vaccine Vaccination Immune Response Trials 105

XTalks

NOVEMBER 22, 2022

Stage 2 is characterized by the presence of diabetes-related antibodies and abnormal levels of blood sugar. Related: GLP-1 Agonists for Diabetes: Mounjaro Versus Ozempic. There are three stages of type 1 diabetes with stage 3 being the step at which a clinical diagnosis is made.

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Insulin Drugs FDA Approval Immune Response 97

Pharmaceutical Technology

JULY 22, 2022

Peter Hotez’s tweet on PAI Life Sciences’ phase 1 trial of its snail fever vaccine. The phase 1 clinical trial will evaluate the safety and immune response of the vaccine in healthy individuals at the Kaiser Permanente Washington Health Research Institute in Seattle, the article detailed. Retweets: 113. Likes: 144.

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Vaccine Vaccination Life Science Immune Response 130

XTalks

JULY 26, 2021

The lab studies involved assessing the activity of neutralizing antibodies from convalescent sera against SARS-CoV-2 and various variants. This may be due to factors such as the analysis including mainly elderly populations that were vaccinated early on and who may not mount as strong of an immune response, and waning antibodies.

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Vaccine Vaccination Immune Response Antibody 98

XTalks

JANUARY 11, 2023

It also seems to be very adept at evading the immune response owing to a plethora of mutations that makes it immune evasive. “It However, XBB gained an advantage over the previous recombinants as it gained a set of mutations from one parent strain that helped it evade antibodies from previous infections and vaccinations.

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Scientist Vaccine Vaccination Genetics 98

XTalks

MAY 7, 2021

It was made using Novavax’s recombinant nanoparticle technology to generate antigen derived from the coronavirus spike (S) protein and contains Novavax’s patented saponin-based Matrix-M as an adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies.

Protein 97

Protein Vaccination Vaccine Trials 97

XTalks

DECEMBER 12, 2023

Plasma medicine is a critical and specialized field within healthcare, centering on the use of human plasma for the development and administration of life-saving treatments. Human plasma, the clear, liquid portion of blood, is composed of water, electrolytes, nutrients and crucial proteins such as antibodies, clotting factors and albumin.

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Medicine Recombinant Antibody Protein Antibody 111

pharmaphorum

SEPTEMBER 22, 2022

When exposed to a virus, one’s immune system develops antibodies in response to foreign antigens, with or without a vaccine. However, a vaccine trains the immune system to recognise that familiar virus and kill it more rapidly. One arm of the immune system triggers antibodies, and the other triggers T-cells.

Vaccine 97

Vaccine Vaccination Antibody Clinical Trials 97

XTalks

JULY 8, 2021

The drugs are monoclonal antibodies against the IL-6 receptor. Patients with severe COVID-19 often have an overactivation of the immune system, which involves the increased release of cytokines (cytokine release syndrome) such as IL-6. By blocking the cytokine from binding to its receptor, the hyperactive immune response can be tamed.

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Doctor Doctors Drugs Manufacturing 98

XTalks

NOVEMBER 30, 2023

Preclinical data demonstrated that HB-500 was well-tolerated, eliciting robust, high-quality and enduring immune responses, including antigen-specific T cells and antibodies, in non-human primates. In November 2023, Hookipa Pharma Inc., Notably, it significantly reduced viral load and clinical illness compared to a placebo.

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FDA Approval Gene Therapy Clinical Trials Clinical Trials 111

XTalks

JANUARY 20, 2021

While diseases like celiac are associated with inappropriate activation of the immune system triggered by food antigens, this is not the case in IBS. In a normal, healthy intestine, foods do not trigger immune responses and so in a patient with IBS, something else must activate the response. Mouse and Human Studies.

Immune Response 52

Immune Response Research Allergies Protein 52

XTalks

AUGUST 17, 2020

Monoclonal antibodies : these are antibodies that are designed to bind to specific targets on cells. Treatment vaccines : these boost the immune system responses to target cells. Immune system modulators (i.e. receptors) of the immune system to enhance, or suppress immune responses.

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Protein Engineer Immune Response In-Vivo 98

XTalks

JUNE 15, 2022

protein that triggers the immune system to generate antibodies against the virus. Adjuvants can help boost the effectiveness of a vaccine and elicit a stronger immune response. Compared to adults, immune responses were approximately two- to three-fold higher in adolescents.

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Vaccine Vaccination Immune Response Protein 59

The Pharma Data

NOVEMBER 1, 2020

Tiziana Life Sciences plc. (“Tiziana” or the “Company”). The scientific concept, to activate nasal mucosal immunity by nasally administered Foralumab, is to fight against the virus in the respiratory tract and lungs,” stated Dr. Shailubhai, CEO and CSO of Tiziana Life Sciences.

Clinical Trials 40

Clinical Trials Clinical Trials Antibody Life Science 40

XTalks

JULY 2, 2021

Conspiracy theories citing similarities between a placental protein called syncytin-1 and the spike protein of the coronavirus started doing the rounds last year, claiming that vaccines based on this spike protein could cause the immune system to attack the placenta and lead to pregnancy issues.

Vaccine 105

Vaccine Vaccination Protein Immune Response 105

XTalks

MAY 4, 2023

A blood test can detect antibodies to gluten, but a definitive diagnosis requires a biopsy of the small intestine. Drug therapy: Other researchers are investigating the use of drugs that could help reduce the immune response to gluten and prevent damage to the small intestine.

Clinical Trials 98

Clinical Trials Clinical Trials Trials Immune Response 98

XTalks

OCTOBER 25, 2022

Imjudo is an anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) monoclonal antibody that blocks the action of CTLA-4. Inhibition of the protein aids in T-cell activation to prime the immune system against cancer cells to induce their death.

FDA Approval 98

FDA Approval Trials Drugs Immune Response 98

XTalks

JUNE 5, 2023

Abrysvo functions as a vaccine by triggering an immune response specifically aimed at RSV preF, which provides protection against RSV-induced LRTD. AstraZeneca revealed promising Phase III results for its single dose long-acting antibody, nirsevimab , against RSV. The vaccine demonstrated 83.7 percent and hospitalizations by 62.1

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Vaccination Vaccine FDA Approval Protein 98

XTalks

NOVEMBER 10, 2020

Interim results of the trial show that all participants developed an antibody response after two doses of the COVID-19 adjuvanted vaccine candidate. We also observed that the antibody levels were higher after vaccination than those observed in convalescent sera from people who recovered from the disease,” said Landry.

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Vaccine Vaccination Trials Immune Response 52

pharmaphorum

OCTOBER 12, 2022

Similar to how we injected mRNA into people to trigger an immune response and train their immune system against COVID-19, genomic medicine repairs cellular or molecular mechanisms that are dysfunctional and cause disease.”. Debiopharm is interested in innovative therapeutic platforms for tomorrow,” Gibbs says. “We

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Genomics Genome Medicine Development 105

XTalks

MARCH 10, 2021

Adding to the testing repertoire is the first T cell-based test that can detect previous infection, akin to antibody tests. Adaptive Biotechnologies’ T-Detect COVID Test is a next-generation sequencing (NGS) test that can indicate recent or prior infection with SARS-CoV-2 through detection of a T cell immune response to the virus.

Protein 98

Protein RNA Antibody Production 98