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The ABCs of Transitioning PK Assays from Preclinical to Clinical

Worldwide Clinical Trials

For studies of humanized therapeutics (monoclonal antibodies [mAb], fusion protein, antibody-drug conjugates [ADC], bispecific antibodies, etc.), a typical format is: receptor/target as capture with a generic binding reagent as detection (e.g., anti-human IgG).

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The Native Antigen Company Launches Range of SARS-CoV-2 Specific Antibodies

BioTech 365

Ten new monoclonal antibodies recognise distinct Spike protein epitopes on SARS-CoV-2 Antibodies available are specific for S1, S2 and receptor-binding domain regions of SARS-CoV-2 Spike protein Different epitopes support identification of matched-pair reagents for immunoassay development OXFORD, England–(BUSINESS WIRE)–The Native … (..)

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IN FOCUS: Syngene International

Pharmaceutical Technology

Its scope includes Syngene providing integrated drug discovery and development solutions in discovery chemistry and biology, peptide chemistry, antibody and protein reagents, pharmacokinetics and drug metabolism, and pharmaceutical development. until 2026. Syngene’s collaboration with Zoetis started in 2011.

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Receptor Occupancy Assays by Flow Cytometry: Benefits for Clinical Trials

XTalks

Generally, antibody-based therapeutics are one of the main types of drugs that are assessed using receptor occupancy assays as they bind to specific cell surface receptors through which they impact downstream intracellular signalling pathways. The antibodies are conjugated to fluorochromes for them to be detected.

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Bio-Techne Announces ISO 13485:2016 Certification for the Woburn, MA Manufacturing Facility

The Pharma Data

15, 2020 /PRNewswire/ — Bio-Techne Corporation (NASDAQ: TECH), a leading provider of proteins, antibodies and cytokines today announced that its Woburn, Massachusetts site received ISO 13485:2016 certification for Medical Device and Quality Management Systems. MINNEAPOLIS , Oct.

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Notch Therapeutics Appoints Cellular Immunotherapy Veteran Chris Bond, Ph.D. as SVP, Preclinical and Translational Sciences

The Pharma Data

Dr. Bond has extensive experience in the discovery and development of adoptive cell therapies, monoclonal antibodies, and cellular engineering and genome editing. He is an inventor on numerous patents and has published papers in the fields of protein structure and engineering, immunology, and oncology. Dr. Bond received a Ph.D.

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Transforming Biomanufacturing: Potential of Cell Free Systems

Roots Analysis

Biomanufacturing utilizing cell free systems is an emerging area of research that enables the synthesis of different biomolecules, such as cytotoxic proteins, fusion proteins, post translationally modified proteins, antibodies, enzymes, vaccines and other complex proteins, without the use of living cells.

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