Pharmaceutical Technology

JANUARY 4, 2023

TST003 is a first-in-class Gremlin1 targeting humanised monoclonal antibody. In the syngeneic tumour model, the monoclonal antibody has also improved the checkpoint inhibitor’s anti-tumour activity. The Gremlin1 protein was found to promote lineage plasticity while driving castration resistance in prostate cancer.

Antibody 242

Antibody In-Vivo In-Vitro Protein 242

Scienmag

JULY 8, 2022

Researchers at the University of Southampton have gained unprecedented new insight into the key properties of an antibody needed to fight off cancer. The interdisciplinary study, published in Science Immunology, revealed how changing the flexibility of the antibody could stimulate a stronger immune response.

Antibody 86

Antibody Immune Response Scientist Research 86

Scienmag

MARCH 5, 2021

Scientists at Walter Reed Army Institute of Research, in a collaboration the Duke University, have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria.

Scientist 74

Scientist Antibody Research Allergies 74

Medical Xpress

JANUARY 17, 2023

A new study led by scientists at La Jolla Institute for Immunology (LJI) shows how ideal antibodies against SARS-CoV-2 hit their marks.

Antibody 98

Antibody Scientist 98

NY Times

OCTOBER 12, 2020

A network of scientists is chasing the pandemic’s holy grail: an antibody that protects against not just the virus, but also related pathogens that may threaten humans.

Antibody 94

Antibody Scientist 94

pharmaphorum

MARCH 9, 2021

Last year, Belgium’s ExeVir Bio raised 23 million euros ($27 million) to finance development of llama antibodies – and now it is ready to begin clinical development of a potential treatment that could be effective against emerging COVID-19 variants. ExeVir is not the first company to spin out of VIB to focus on camelid antibodies.

Antibody 98

Antibody Life Science Scientist Development 98

Medical Xpress

APRIL 25, 2023

In a new investigation, scientists from La Jolla Institute for Immunology (LJI) have shown how antibodies, collected from this clinical study volunteer, bind to the SARS-CoV-2 "Spike" protein to neutralize the virus. An anonymous San Diego resident has become a fascinating example of how the human immune system fights SARS-CoV-2.

Antibody 98

Antibody Protein Scientist 98

Scienmag

MAY 4, 2022

LA JOLLA, CA—Getting sick with a common cold doesn’t make you immune to COVID-19, but a COVID-19 infection might, at least temporarily, boost the number of antibodies you have against common cold-causing coronaviruses and the SARS-CoV-1 and MERS-CoV viruses, all of which are closely related.

Antibody 86

Antibody Scientist Research Medicine 86

pharmaphorum

MARCH 16, 2021

million ($2 million) to develop its artificial intelligence-based platform for discovering therapeutic antibodies. The Cardiff, Wales startup is combining machine learning and phage display techniques to model antibody-antigen binding and says it can cut the time it takes to develop a drug candidate.

Antibody 101

Antibody Bioavailability Engineer Drugs 101

Worldwide Clinical Trials

OCTOBER 14, 2024

Scientists now use cutting-edge techniques, including biological therapies that target specific immune system components and precision medicine approaches that personalize treatment plans based on a patient’s genetic profile.

Research 147

Research Clinical Trials Clinical Trials Immune Response 147

pharmaphorum

JULY 27, 2021

Boehringer Ingelheim’s latecomer antibody therapy for COVID-19 has been side-lined, as the company focuses its attention on its thrombolytic drug alteplase, heading into a phase 3 programme later this year. The hope was that an inhaled antibody would reach higher levels in the lung, where it is most needed, than systemic antibodies.

Antibody 98

Antibody Clinical Development Development Scientist 98

Worldwide Clinical Trials

OCTOBER 14, 2024

Scientists now use cutting-edge techniques, including biological therapies that target specific immune system components and precision medicine approaches that personalize treatment plans based on a patient’s genetic profile.

Research 130

Research Clinical Trials Clinical Trials Immune Response 130

STAT News

AUGUST 23, 2022

As the world continues to learn how to live with Covid-19 in the long run, scientists are testing ways to quickly tell people how well-protected they are against the virus, and whether they need another booster.

Scientist 98

Scientist Development Antibody 98

Scienmag

SEPTEMBER 24, 2020

Findings point the way to developing a broad-spectrum flu drug Credit: Yanan Dai Researchers have identified two antibodies that protect mice against lethal infections of influenza B virus, report scientists at Washington University School of Medicine in St. Together with an antibody that targets the other […].

Antibody 81

Antibody Medicine Scientist Development 81

Scienmag

MAY 31, 2022

LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have published the first analysis of how four types of COVID-19 vaccines prepare the body to fight SARS-CoV-2.

Scientist 79

Scientist Vaccine Vaccination Antibody 79

pharmaphorum

SEPTEMBER 10, 2021

” The antibody, which is partnered with Eisai, made second-quarter sales of $1.6 As Vounatsos was updating investors and analysts on progress, a group of scientists at Beth Israel Deaconess Medical Center (BIDMC) published a letter in the Journal of the American Medical Association (JAMA) taking issue with the revised label for Aduhelm.

Scientist 96

Scientist Sales Clinical Trials Clinical Trials 96

Scienmag

OCTOBER 26, 2021

A study conducted by a consortium of Brazilian researchers has demonstrated that a hyperimmune serum consisting of purified antibody fragments produced in horses may be an efficient approach to combat covid-19. The neutralizing activity of the sera developed by the scientists has been proved to be […].

Antibody 76

Antibody Scientist Development Research 76

STAT News

NOVEMBER 21, 2022

Centuries later, scientists now know this to be a circadian rhythm, a 24-hour cycle that readjusts in response to environmental cues such as sunlight. Studies show that wounds heal faster during the day, and patients over 65 produce more antibodies if they get a flu shot in the morning. Read the rest…

Scientist 98

Scientist Antibody Research 98

Pharmaceutical Technology

FEBRUARY 22, 2023

The patent battle between Amgen and Sanofi over their cholesterol-lowering antibodies has divided big pharma in the past months. Both drugs are monoclonal antibodies that inhibit the protein PCSK9. To an extent, the challenge here lies in the nature of antibodies, says Contreras. Amgen’s Repatha was greenlit a month later.

Antibody 262

Antibody Drugs Protein Sales 262

World of DTC Marketing

APRIL 11, 2021

A second study by scientists in the United States, published alongside the Imperial-led one in the journal Nature, estimated that lockdowns in China, South Korea, Italy, Iran, France and the United States had prevented or delayed around 530 million COVID-19 cases.

Vaccination 303

Vaccination Vaccine Clinical Trials Clinical Trials 303

Scienmag

APRIL 22, 2021

Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.

Antibody 59

Antibody Scientist Research Medicine 59

Scienmag

OCTOBER 21, 2021

WHAT: A booster dose of the mRNA-1273 COVID-19 vaccine given to rhesus macaques about six months after their primary vaccine series significantly increased levels of neutralizing antibodies against all known SARS-CoV-2 variants of concern, according to a new study from National Institutes of Health scientists and colleagues.

Antibody 70

Antibody Vaccine Vaccination Scientist 70

Scienmag

JUNE 29, 2021

Six antibody features help protect pregnant women against placental malaria infections, and could be used to identify women at risk of the disease and related complications Six antibody characteristics could help scientists identify which pregnant women are at risk of placental malaria infections, finds a study published today in eLife.

Antibody 65

Antibody Scientist Allergies Medicine 65

Medical Xpress

APRIL 4, 2023

Critically ill COVID-19 patients often have antibodies in their blood that bind to the body's own structures, so-called autoantibodies. Scientists from the BIH at Charité and the Max Delbrück Center have now discovered that these autoantibodies frequently bind to not just one but multiple targets.

Scientist 124

Scientist Antibody 124

Scienmag

APRIL 9, 2021

Using a novel toolkit of approaches, the scientists uncovered the […].

Antibody 93

Antibody Protein Scientist Research 93

Scienmag

SEPTEMBER 23, 2021

LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have published a detailed map of where human antibodies bind to SARS-CoV-2, a map that was generated by a global collaboration comparing nearly all leading clinical candidates.

Antibody 65

Antibody Scientist Development Research 65

Scienmag

FEBRUARY 17, 2022

Scientists pinpoint mechanisms associated with severe COVID-19 blood clotting WHAT: After studying blood samples from 244 patients hospitalized for COVID-19, a group of researchers, including those who work at the National Institutes of Health, identified “rogue antibodies” that correlate with severe illness and may help explain mechanisms associated (..)

Scientist 62

Scientist Antibody Research 62

Pharmaceutical Technology

JULY 6, 2022

Scientists at the National Institutes of Health (NIH) unit National Institute of Neurological Disorders and Stroke (NINDS) have found that Covid-19-induced immune response could damage the blood vessels of the brain and may lead to short and long-term neurological symptoms. .

Immune Response 162

Immune Response Antibody Gene DNA 162

Medical Xpress

JANUARY 27, 2023

COVID vaccines call our immune systems to action, generating antibodies which fight against any contact we have with the virus. Antibodies help to reduce the effects of an infection or even prevent it altogether. Scientists have estimated that vaccination has averted millions of COVID deaths worldwide.

Vaccine 98

Vaccine Vaccination Antibody Scientist 98

Scienmag

FEBRUARY 25, 2021

Research from the California Institute of Technology shows exactly how antibodies stick to and block the Zika virus, which will inform vaccine development Credit: Image courtesy of Shannon Esswein.

Antibody 52

Antibody Scientist Vaccination Vaccine 52

Medical Xpress

FEBRUARY 14, 2023

The immune system fights the coronavirus with antibodies and T cells. Scientists have a fairly good idea of how the virus avoids antibodies, including those promoted by vaccination, which is how variants of concern such as the omicron are known to appear. T cell evasion, on the other hand, has remained poorly understood.

Antibody 98

Antibody Scientist Vaccination Vaccine 98

Scienmag

OCTOBER 22, 2020

The testing criteria had yet to be expanded to include individuals with Smith’s symptoms and so he did what many scientists with […]. Stephen Smith of Seattle Children’s Research Institute came down with muscle aches, gastrointestinal distress and a sudden loss of smell in late February, he suspected he had COVID-19.

Scientist 52

Scientist Antibody Development Research 52

Scienmag

NOVEMBER 4, 2020

Credit: Rayne Zaayman-Gallant/EMBL The ability of SARS-CoV-2 to infect cells depends on interactions between the viral spike protein and the human cell surface protein ACE2. To enable the virus to hook onto the cell surface, the spike protein binds ACE2 using three finger-like protrusions, called the receptor binding domains (RBDs).

Scientist 65

Scientist Antibody Protein Medicine 65

pharmaphorum

AUGUST 12, 2021

A single dose of a monoclonal antibody developed by scientists at the US National Institutes of Health (NIH) has provided protection for people exposed to malaria parasites for up to nine months. The post More malaria hope as antibody protects against infection appeared first on.

Antibody 64

Antibody Vaccination Vaccine Allergies 64

pharmaphorum

MAY 3, 2022

A scientist working in Switzerland has become the fifth person to be convicted of attempting to steal trade secrets from pharmaceutical group GlaxoSmithKline in a case that stretched back several years. ” The post Fifth scientist convicted in GSK trade secrets case appeared first on.

Scientist 69

Scientist Branding Production Antibody 69

BioPharma Reporter

MAY 20, 2021

Data management in antibody drug conjugate (ADC) manufacturing is challenging says ADC/Labs, which is trying to help scientists in the field get around such obstacles.

Manufacturing 95

Manufacturing Antibody Scientist Drugs 95

Scienmag

JUNE 1, 2021

Army scientists working as part of an international consortium have developed and tested an antibody-based therapy to treat Crimean-Congo hemorrhagic fever virus (CCHFV), which is carried by ticks and kills up to 60 percent of those infected. Their results are published online today in the journal Cell.

Scientist 57

Scientist Development Antibody Allergies 57