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Pseudomonas aeruginosa, a common environmental bacterium, can colonize different body parts, such as the lungs, leading to persistent, chronic infections that can last a lifetime – a common occurrence in people with cystic fibrosis. “Our study took a novel approach to look directly into the bacterium’s behavior in the human host.”
We are talking about the microbiome – the vast collection of bacteria in the human gut. The microbiome has been the focus of research for 20 years – ever since a new technique made it possible to analyse these bacteria quickly and precisely: high-throughput sequencing. In doing so, they induce epigenetic changes.
Doudna, PhD, of the University of California, Berkeley and Emmanuelle Charpentier, PhD, of the Max Planck Unit for the Science of Pathogens Institute for Infection Biology, revolutionized genetic research by helping to identify a natural gene editing mechanism in bacteria.
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