AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 23, 2024

The eye is exposed to the elements so it’s a window for bacteria and viruses to enter the body – potentially causing death. Ultra long, thick eyelashes might be in vogue but are they worth the expense – and the risk to health? Our natural eyelashes perform important functions. Eyelashes protect our eyes by diverting […]

Bacteria 246

Bacteria Clinical Trials Clinical Trials Trials 246

ProRelix Research

SEPTEMBER 7, 2023

Autoimmune disorders comprise several diseases in which the immune system mistakenly attacks and destroys the body’s own healthy cells instead of destroying bacteria and viruses to keep the body healthy. […] The post Autoimmune disorders and current developments of novel treatments under clinical trials appeared first on ProRelix Research.

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Clinical Trials Clinical Trials Trials Development 105

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 23, 2024

But bacteria aren’t the only mutating pathogens we need to worry about. (Tanja Ivanova/Getty Images) The world is in the midst of an antibiotic resistance crisis that contributes to the death of nearly 5 million people a year.

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Scientist Bacteria Medicine Clinical Trials 245

AuroBlog - Aurous Healthcare Clinical Trials blog

OCTOBER 26, 2023

Many tiny organisms including bacteria, fungi and viruses normally live on our bodies, and even inside us. These are called the microbiome. The large number of these organisms living in the gastrointestinal tract are collectively known as the gut microbiome.

Bacteria 246

Bacteria Clinical Trials Clinical Trials Clinical Research 246

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 2, 2022

Scientists have discovered DNA-damaging molecules made by gut bacteria that may help explain why people with inflammatory bowel disease (IBD) have higher rates of colorectal cancer than those without the condition.

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DNA Bacteria Scientist Research 245

AuroBlog - Aurous Healthcare Clinical Trials blog

JANUARY 11, 2024

Researchers have identified an entirely new class of antibiotic that can kill bacteria that are resistant to most current drugs.

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Bacterium Bacteria Drugs Research 242

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 14, 2023

Called the gut microbiome, this dazzling collection of bacteria and other microorganisms has been the source of much attention – linked to a vast array of health conditions, from autism spectrum disorder and diabetes, to depression, […]

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Bacteria Clinical Trials Clinical Trials Clinical Research 239

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 28, 2023

Golden staph are ubiquitous bacteria, living harmlessly on the skin or inside the nose of nearly one in three people worldwide. Yet they are duplicitous, too. In some situations, golden staph (Staphylococcus aureus) can become monsters, causing dangerous infections in the skin, blood, bones, or elsewhere.

Scientist 246

Scientist Bacteria Drugs Clinical Trials 246

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 9, 2022

Instead of the vaccine only protecting against the target bacteria – Myocbacterium tuberculosis – the tuberculosis vaccine offered broad protection against a range of unrelated infections, including respiratory infections and serious complications such as sepsis.

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Vaccine Vaccination Bacteria Research 246

XTalks

JULY 31, 2020

A study published in Nature on July 30, 2020 states that good bacteria living in our gut can do much more than just help digest food and boost our immune system. According to studies conducted by researchers at Cincinnati Children’s Hospital, the bacteria can help heal damaged intestinal tissues.

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Bacteria Genetic Engineering Engineer Research 98

XTalks

NOVEMBER 7, 2024

Research suggests that certain bacteria, particularly those associated with Demodex mites (tiny mites that naturally live on human skin) like Bacillus oleronius , could contribute to rosacea in some individuals. Other studies suggest that Helicobacter pylori bacteria infections may also cause rosacea.

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FDA Approval Dermatology Bacteria Clinical Trials 105

XTalks

NOVEMBER 12, 2024

Pneumonia is a lung infection that can be caused by viruses, bacteria or fungi and can result in millions of hospitalizations and deaths annually. For example, recent clinical trials and regulatory approvals for RSV vaccines are notable milestones that indicate advancements in preventing viral pneumonia in both children and elderly adults.

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Bacteria Life Science Vaccination Vaccine 110

Scienmag

MARCH 11, 2021

A new clinical study has shown that supplements of a lactic acid bacterium may have positive effects by increasing the diversity of intestinal bacteria in these infants. Extremely preterm infants can suffer from a life-threatening inflammation of the gut.

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Bacteria Bacterium Research Clinical Trials 72

Pharmaceutical Technology

DECEMBER 14, 2022

Bacteria naturally develop resistance to antibiotics over time, through genetic mutation, horizontal gene transfer between bacteria, or because of selective pressure. Virus versus bacteria. Phages are viruses of bacteria. Secondly, the relationships between phages and bacteria are very specific.

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Bacteria DNA Clinical Trials Clinical Trials 130

Pharmaceutical Technology

OCTOBER 6, 2022

Additionally, it will work on non-clinical toxicity (TOX) and Clinical Trial Material batch to conduct a Phase I clinical trial of the vaccine in healthy adult subjects. This trial will evaluate the safety of the vaccine and generate efficacy data.

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Vaccine Vaccination Development Bacterium 147

Medical Xpress

APRIL 17, 2023

A randomized clinical trial is looking at whether fecal microbiota transplantation (FMT) from healthy donors into adults with early-stage amyotrophic lateral sclerosis (ALS—one of the most common forms of motor neuron disease) can modulate the immune reaction during inflammation responses that characterize disease progression, and aims to investigate (..)

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Bacteria Clinical Trials Clinical Trials Trials 98

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 7, 2022

In cases where picking at your nose damages internal tissues, critical species of bacteria have a clearer path to the brain, which responds to their presence in ways that resemble signs of Alzheimer’s disease. […].

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Bacteria Development Clinical Trials Clinical Trials 130

Pfizer

FEBRUARY 16, 2023

These study participants, representing approximately half of the total recruited participants in the trial, are being discontinued following violations of Good Clinical Practice (GCP) at certain clinical trial sites run by a third-party clinical trial site operator. FDA in July 2017.

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Clinical Trials Clinical Trials Vaccine Vaccination 76

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Using Bacteria For Therapy. Some trials had to be terminated due to severe toxicity.”

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Bacteria Engineer Drugs Research 52

XTalks

JULY 18, 2022

Medical imaging company MolecuLight reported results from their recent clinical trial that evaluated the use of their fluorescence imaging device MolecuLight i:X to detect elevated bacterial loads in diabetic foot ulcers. Clinical Trial of MolecuLight i:X in Wound Healing of Diabetic Foot Ulcers.

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Clinical Trials Clinical Trials Bacteria Trials 105

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 22, 2022

The research involves using spherical vesicles secreted by bacteria coated on gold nanoparticles which can then be delivered to the immune cells. The Indian Institute of Science (IISc), Centre for BioSystems Science and Engineering, has designed a new method to deliver a vaccine candidate for tuberculosis (TB).

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Vaccine Vaccination Research Bacteria 100

Scienmag

APRIL 19, 2021

Researchers from Aarhus University and Aarhus University Hospital replace sick intestinal bacteria with intestinal bacteria from healthy donors in a treatment intended to help patients with cirrhosis of the liver. The Novo Nordisk Foundation supports the Credit: Simon Mark Dahl Baumwall.

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Bacteria Research Clinical Trials Clinical Trials 94

Medical Xpress

JANUARY 17, 2023

A promising approach to control Staphylococcus aureus bacterial colonization in people—using a probiotic instead of antibiotics—was safe and highly effective in a Phase 2 clinical trial. aureus colonization in trial participants without harming the gut microbiota, which includes bacteria that can benefit people.

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Trials Allergies Bacteria Clinical Trials 80

Pharmaceutical Technology

JUNE 14, 2023

The therapy comprises liposomes engineered to capture the virulence factors, which are produced by a wide range of Gram-positive and Gram-negative bacteria. The company is currently evaluating CAL02 in a Phase II clinical trial, which is expected to enrol 276 SCABP patients globally.

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Bacteria Engineer Clinical Trials Clinical Trials 130

XTalks

OCTOBER 29, 2024

Although UTIs are often straightforward to treat, they are commonly caused by strains of bacteria increasingly resistant to traditional antibiotics, such as amoxicillin and ciprofloxacin. Orlynvah was generally well tolerated in both SURE 1 and REASSURE clinical trials.

FDA Approval 105

FDA Approval Bacteria Clinical Trials Clinical Trials 105

XTalks

OCTOBER 29, 2024

Although UTIs are often straightforward to treat, they are commonly caused by strains of bacteria increasingly resistant to traditional antibiotics, such as amoxicillin and ciprofloxacin. Orlynvah was generally well tolerated in both SURE 1 and REASSURE clinical trials.

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FDA Approval Bacteria Clinical Trials Clinical Trials 98

Rethinking Clinical Trials

JUNE 6, 2023

“We have a tool that not only flags a low-risk patient, but is doing it based on data from the EMR [electronic medical record] system, and is calculating risk specific to a patient, specific to a disease, and specific to a type of bacteria, and one that is unique to a hospital.

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Trials Clinical Trials Clinical Trials Allergies 130

Delveinsight

JANUARY 28, 2021

Nirogy’s lead program aims lactate transporters for cancer treatment and is anticipated to enter human clinical trials in 2022. The NDA submission comprises data from the SURE-1, SURE-2 and SURE-3 phase 3 clinical trials, in which oral sulopenem was well tolerated with no major drug-related adverse events.

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Bacteria Trials Drugs Clinical Trials 52

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The therapeutic candidate comprises of consortia of immune-modulating microbiome-derived bacteria. VE-818 overview VE-818 is under development for the treatment of graft versus host disease (GVHD).

Bacteria 100

Bacteria Clinical Trials Clinical Trials Clinical Development 100

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The therapeutic candidate comprises of consortia of immune-modulating microbiome-derived bacteria. VE-818 overview VE-818 is under development for the treatment of graft versus host disease (GVHD).

Bacteria 100

Bacteria Clinical Trials Clinical Trials Clinical Development 100

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The drug candidate is consortia of live bacteria based on microbiome-derived live biotherapeutic.

Bacteria 100

Bacteria Clinical Trials Clinical Trials Drugs 100

Pharmaceutical Technology

MARCH 4, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The drug candidate is consortia of live bacteria based on microbiome-derived live biotherapeutic.

Bacteria 100

Bacteria Clinical Trials Clinical Trials Drugs 100

pharmaphorum

OCTOBER 7, 2020

Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. million) Nobel Prize award. “In

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Gene Editing Bacteria DNA Gene 105

XTalks

MAY 31, 2022

Tapinarof was discovered as an outcome of investigations into the secondary metabolites of Photorhabdus luminescens, a bioluminescent, Gram-negative bacteria. XTALKS WEBINAR: All Means All: The Road to Inclusivity in Clinical Trials. Clinical Trials of Vtama. There is 10 mg of tapinarof per gram of Vtama cream.

FDA Approval 98

FDA Approval Clinical Trials Clinical Trials Trials 98

Camargo

JULY 27, 2021

Viruses and bacteria can be first modified to prevent them from causing infectious diseases and then implemented into human tissues as therapeutic gene vectors. While most gene therapy clinical studies are ongoing, a number of products are in advanced clinical development, and several are approved by FDA.

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Gene Therapy Gene Gene Editing Genetics 238

Pharmaceutical Technology

MAY 31, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. It comprises of a single strain of killed and intact, non-pathogenic gram bacteria with reduced LPS-endotoxin activity. it is administered through intravenous route.

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Drug Delivery Systems Drug Delivery Bacteria Drugs 100

Rethinking Clinical Trials

OCTOBER 3, 2024

They found that trachoma distributions and the childhood mortality distributions do select for macrolide resistance in a number of different bacteria, with resistance decreasing when the programs are stopped. The team is hoping to eventually create a platform to monitor and coordinate treatment efforts between trials.

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Trials Bacteria Research Clinical Trials 100