Scienmag

JUNE 21, 2022

HOUSTON – (June 21, 2022) – It’s a given that certain bacteria and viruses can cause illness and disease, but the real culprits are the sequences of concern that lie within the genomes of these microbes. Credit: Treangen Lab/Rice University HOUSTON – (June 21, 2022) – It’s a given that certain bacteria and viruses can […].

DNA 62

DNA Bacteria Genomics Genome 62

Camargo

JULY 27, 2021

It is a comprehensive term which encompasses a large variety of therapy products including viral and bacterial vectors, plasmid DNA, human gene editing technology, and patient-specific cellular gene therapy. Formulation Considerations.

Gene Therapy 238

Gene Therapy Gene Gene Editing Genetics 238

Scienmag

JUNE 21, 2022

The last two decades have seen the development of sophisticated computational tools that explore the DNA of bacteria. These tools are on the lookout for interesting metabolites (metabolism-related molecules) that illicit a strong biological reaction.

Bacteria 86

Bacteria DNA Gene Development 86

Medical Xpress

FEBRUARY 13, 2023

The gut microbiota contains trillions of bacteria that can promote health or cause disease under different conditions. The collective DNA sequences that make up the bacteria flora, is called the microbiome.

Bacteria 69

Bacteria DNA Containment Research 69

Scienmag

JANUARY 22, 2021

coli enzyme synthesizing ribosomal RNA that shift it between turbo- and slow-modes depending on the bacteria’s growth rate Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the […].

RNA 85

RNA Production Regulation Bacteria 85

Scienmag

FEBRUARY 5, 2021

An international research group led by the University of Bologna achieved this result by extracting and analysing ancient DNA from 50,000-year-old faecal sediments sampled at the archaeological site of El Salt, near Alicante (Spain). Published […].

Bacteria 63

Bacteria DNA Research 63

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Using Bacteria For Therapy. ” The Ideal Bacteria.

Bacteria 52

Bacteria Engineer Drugs Research 52

pharmaphorum

OCTOBER 7, 2020

Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. million) Nobel Prize award.

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Gene Editing Bacteria DNA Gene 105

BioTech 365

MAY 7, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study describes new mechanism for terminating transcription of DNA into RNA in bacteria.A bacterial protein helps to stop transcription—the process of making RNA copies of DNA to … Continue reading →

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RNA DNA Bacteria Protein 40

Pharmaceutical Technology

FEBRUARY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

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In-Vivo Genomics Genome Gene Editing 163

Scienmag

JULY 1, 2022

One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Researchers have found that in bacteria DNA methylation plays a role in regulating virulence, reproduction and gene […].

Regulation 63

Regulation Gene DNA Bacteria 63

pharmaphorum

JANUARY 20, 2021

This sticky mucus gets trapped and breeds infections from bacteria I inhale,” says Ella, who adds she was “terrified” of doctors as a child. The bacteria become more resistant to antibiotics and that makes them harder to clear. I would spend two or three weeks at a time in hospital on antibiotics.”. I was really sick.

Bacteria 113

Bacteria Bacterium DNA Doctors 113

Roots Analysis

OCTOBER 16, 2023

DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence.

DNA 40

DNA Gene Protein In-Vitro 40

Scienmag

MAY 7, 2021

Study describes new mechanism for terminating transcription of DNA into RNA in bacteria Credit: Babitzke Laboratory and Dani Zemba, Penn State The protein, known as NusG, pauses the transcription machinery at specific DNA sequences to facilitate what is called “intrinsic termination” and prevent unwanted transcription that could disrupt (..)

Genetics 53

Genetics DNA Bacteria RNA 53

Roots Analysis

MARCH 1, 2023

Disruption of the integrity and function of DNA at the gene or chromosomal level can lead to heritable mutations, resulting in genetic disorders, birth abnormalities, or cancer. Mechanism of Genotoxicity / Mutagenicity The interaction of genotoxins / mutagens with the structure of DNA causes damage to the genetic material.

Genotoxicity 52

Genotoxicity DNA Genetics Bacteria 52

Delveinsight

JULY 26, 2021

Often the bacteria develop antibiotic resistance to certain drugs, leaving it non-effective for the usage the second time in the case of recurrence of the infection that occurs in approximately 30-35% of the uUTI cases, therefore, leaving a serious dearth of the new antibiotics. coli bacteria called FimH.

Marketing 93

Marketing Bacteria Development Vaccine 93

Pharmaceutical Technology

FEBRUARY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

Vaccine 130

Vaccine Vaccination Containment Immune Response 130

pharmaphorum

APRIL 23, 2021

Founded by Nobel prize winner Emmanuelle Charpentier, CRISPR Therapeutics has been at the forefront of gene editing technology and has refined its technology to the point where it can be used to accurately edit someone’s DNA to correct genetic conditions.

Gene Editing 64

Gene Editing Gene DNA Bacteria 64

pharmaphorum

SEPTEMBER 14, 2020

The human genome is too long to be sequenced as one continuous string by current technology – so short-read sequencing breaks DNA into short fragments that are amplified and then sequenced to produce ‘reads’ of around 150 nucleotides in length. To address these issues, scientists and clinicians are starting to look at ‘long-read’ sequencing.

Genome 119

Genome Genomics Medicine Gene 119

XTalks

NOVEMBER 19, 2021

No one enjoys cold food, but once it drops below 140 degrees F, bacteria can form on the surface. InnerPlant, a startup that edits the DNA of plants to enable them to glow a certain color when the plant is under attack from pests or fungal infection or is stressed from lack of water. Upside Foods, a maker of cultured chicken.

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Bacteria Packaging Packaging DNA 97

pharmaphorum

MAY 7, 2021

Founded by Nobel prize winner Emmanuelle Charpentier, CRISPR Therapeutics has been at the forefront of the gene editing technology and has refined it to the point where it can be used to accurately edit DNA to correct genetic conditions or modify cells to fight disease.

Gene Editing 52

Gene Editing Gene Genetic Engineering DNA 52

The Pharma Data

JANUARY 4, 2021

But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. “Essentially, what Justin did was to create a series of DNA instructions you can give to cells that will enable them to survive when fluoride is around,” said O’Malley.

Engineer 52

Engineer Bacteria Genetics Genetic Engineering 52

Roots Analysis

FEBRUARY 27, 2024

How many of the ADCs in development have pyrrolobenzodiazepine (PBD) as warhead: Pyrrolobenzodiazepines are a class of compounds that kill cells by binding their DNA and interfering with replication. In nature, they are made by a group of bacteria known as actinomycetes.

Antibody 52

Antibody Licensing Licensing Contract Manufacturing 52

The Pharma Data

DECEMBER 2, 2020

Results show the protocol demonstrated a 30Gb+ yield of long DNA reads raw data of an E. The FMv8 protocol introduces a needle-aspirate-based, cell-resuspension step prior to cell lysis that boosts DNA recovery. aeruginosa bacteria, instead of killing the bacteria as an antibiotic would aim to do.

Drugs 52

Drugs Gene Editing Genomics Genome 52

Roots Analysis

AUGUST 31, 2023

coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium. Gene switches can be regulatory proteins or specific DNA sequences that act to either switch on or off the expression of a gene.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

The Pharma Data

SEPTEMBER 28, 2021

Respiratory infections are caused by a good sort of pathogens, like influenza viruses, respiratory syncytial virus, parainfluenza viruses, metapneumovirus, rhinovirus, enterovirus, coronavirus and adenovirus, and other bacteria pathogens.

Marketing 52

Marketing In-Vitro DNA Bacteria 52

Roots Analysis

OCTOBER 16, 2023

Membrane Filters: Membrane filters are typically used for sterilization and removal of smaller impurities such as bacteria and viruses. It removes bacteria, viruses and other debris using microfiltration, ultrafiltration and nanofiltration. are used to remove any residual bacteria, viruses, or endotoxins.

Bacteria 40

Bacteria Production Protein Contamination 40

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

Roots Analysis

JANUARY 14, 2024

Different types of expression system for the production of biologics have been mentioned in the following sections: Insect Expression Systems: Baculovirus is a double stranded DNA (dsDNA) lytic virus that can be effectively amplified in insect cells belonging to the Lepidoptera family.

Contract Manufacturing 40

Contract Manufacturing Protein Manufacturing Production 40

XTalks

DECEMBER 22, 2021

The gene-editing tool CRISPR edits DNA using specialized strands of guide RNA and endogenous cellular mechanisms of RNA interference. They can provide continuous real-time monitoring of metabolites, bacteria, hormones, glucose and other elements in these fluids. Minimally Invasive Devices.

Life Science 98

Life Science RNA Vaccine Vaccination 98

XTalks

FEBRUARY 11, 2021

For example, British scientist Rosalind Franklin gained recognition for her work after her death, which is not unheard of, but with it came the revelation that her work, which helped demonstrate the double helical structure of DNA, went largely uncredited by famed DNA duo James Watson and Francis Crick.

Genetics 119

Genetics DNA Genomics Genome 119

XTalks

NOVEMBER 28, 2023

Following passive diffusion into the organism, metronidazole is activated in the cytoplasm of susceptible anaerobic bacteria through reduction. The reduced form of metronidazole, along with free radicals, interacts with DNA, inhibiting DNA synthesis and causing DNA degradation, ultimately leading to the demise of the bacteria.

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FDA Approval Bacteria DNA Drugs 103

XTalks

FEBRUARY 11, 2021

The drugmaker is targeting various steps in the manufacturing process, beginning right at the DNA stage, which is required as the template from which the mRNA for the SARS-CoV-2 spike protein in the vaccine is made. DNA Templates: The vaccine development process first begins with raw ingredients coming together at the Chesterfield plant.

Manufacturing 52

Manufacturing Vaccine Vaccination DNA 52

Advarra

OCTOBER 10, 2024

Some have argued bacteria are developing antibiotic resistance faster than we can research, develop, test and approve new antibiotics. One possible solution to antibiotic resistance: bacteriophages (or phages), which are viruses that infect bacteria. These resistance genes are commonly found on small circles of DNA called plasmids.

Bacteria 52

Bacteria Genetics Genetic Engineering Gene 52

The Pharma Data

JANUARY 21, 2021

The test valuates mitochondrial DNA levels. When mitochondrial DNA, normally found inside cells, in the mitochondria, spills into the bloodstream, it signals that a particular type of violent cell death is occurring. They measured the patients’ mitochondrial DNA levels on the first day of their hospital stays.

Research 52

Research DNA Hormones Vaccine 52

The Pharma Data

OCTOBER 14, 2020

CARB-X will provide Polyphor with initial funding of up to $2.62 million to complete the hit-to-lead stage and up to USD 15.82 million if certain project milestones are met.

Clinical Trials 52

Clinical Trials Clinical Trials Manufacturing In-Vivo 52

XTalks

AUGUST 2, 2023

2) Botox Therapeutic/Cosmetic Botox, or botulinum neurotoxin, is a neurotoxic protein produced by the Clostridium botulinum bacteria. 5) Lynparza (Olaparib) Lynparza is a PARP inhibitor , meaning it inhibits poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. AbbVie’s total global revenue for Humira was $21.24

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Sales Manufacturing FDA Approval Life Science 98