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Global advances in synthetic biology

Drug Discovery World

It is believed that the term synthetic biology was created in 1970 by geneticist, Waclaw Szybalski 1 as work was being carried out on the development of DNA sequencing and synthesis techniques. The Rockefeller University 2 recently reported the development of a synthetic antibiotic that could potentially work against drug-resistant bacteria.

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How digital innovation is helping therapeutics to get to market faster

Drug Discovery World

Sanofi has stated that it intends to become the first pharma company “powered by AI at scale”, and as part of this ambition, agreed a collaboration with BioMap to co-develop advanced AI models and protein Large Language Models that that it hopes will enable biologics design and multiparametric optimisation 2. Obulytix is not alone.

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New gene-editing tool is more accurate than CRISPR

Drug Discovery World

Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than CRISPR. With CRISPR you need extra components to have a ‘cut-and-paste tool’, whereas the promise of seekRNA is that it is a stand-alone ‘cut-and-paste tool’ with higher accuracy that can deliver a wide range of DNA sequences.”

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Women in Science Who Have Paved the Way Forward in Genetics

XTalks

Much of the fundamental groundwork for genetics and genomic research was laid in the 20 th century, with significant contributions from women scientists, some of whom worked during times when acceptance of female researchers was not widespread. Born in Notting Hill, London, England to a prosperous British Jewish family on July 25, 1920.

Genetics 119
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The inner workings of antibiotics

Drug Discovery World

Dr Luke Clifton , Instrument Scientist at ISIS Neutron and Muon Source, explains the molecular mechanism behind antibiotics. The two main classes of bacteria are separated based on their differing cell surface architecture. The two main classes of bacteria are separated based on their differing cell surface architecture.

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The future outlook for mRNA therapies

Drug Discovery World

Its job is to carry coding information that is essential to the translation and processing of functional proteins. This is essential to its use as a therapeutic agent and gives the technology a vast versatility making it suitable to treating a wide range of diseases – especially those that have high protein expression.

RNA 52
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The doors CRISPR libraries have and will open in phenotypic drug screening 

Drug Discovery World

Steve Wowk , VP, Business Unit and General Management of Integrated DNA Technologies, shared with DDW the value of CRISPR-Cas9 in drug discovery. In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome. CRISPR libraries: Why do we need them?

Genome 52