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These DNA-Damaging Molecules May Be The Link Between Colon Cancer And IBD

AuroBlog - Aurous Healthcare Clinical Trials blog

Scientists have discovered DNA-damaging molecules made by gut bacteria that may help explain why people with inflammatory bowel disease (IBD) have higher rates of colorectal cancer than those without the condition.

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Are scientists being fooled by bacteria?

Scienmag

For decades, a small group of cutting-edge medical researchers have been studying a biochemical, DNA tagging system, which switches genes on or off. Many have studied it in bacteria and now some have seen signs of it in, plants, flies, and even human brain tumors. However, according to a new study by researchers at the […].

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New CRISPR-Based Tool Called PASTE Gene Editing Inserts Large DNA Sequences at Desired Sites

XTalks

Developed by MIT researchers Jonathan Gootenberg and Omar Abudayyeh, PASTE (Programmable Addition via Site-specific Targeting Elements) gene editing technology can insert genes as long as 36,000 DNA base pairs to liver cells in mice as well as several types of human cells.

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Engineering an “invisible cloak” for bacteria to deliver drugs to tumors

The Pharma Data

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Using Bacteria For Therapy. ” The Ideal Bacteria.

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CRISPR pioneers Doudna and Charpentier claim Nobel chemistry prize

pharmaphorum

Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. million) Nobel Prize award. “In

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Could Fluoride be the Solution to Antibiotic Resistance? A New Study Weighs In

The Pharma Data

But scientists at the University of California (UC), Santa Barbara, believe fluoride may offer hope in the fight against antibiotic-resistant bacteria. ” This method may also provide significant cost-savings, particularly in relation to antibiotic-driven selection in research laboratories. ” Source link.

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The future of genomic medicine: can it fulfil its promises?

pharmaphorum

The human genome is too long to be sequenced as one continuous string by current technology – so short-read sequencing breaks DNA into short fragments that are amplified and then sequenced to produce ‘reads’ of around 150 nucleotides in length. To address these issues, scientists and clinicians are starting to look at ‘long-read’ sequencing.

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