Scienmag

OCTOBER 12, 2020

Potential new antibiotics work by disrupting bacterial membrane and summoning immune cells in animal models PHILADELPHIA–A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom.

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XTalks

JANUARY 6, 2021

One nanobody in particular, called NIH-CoVnb-112, was shown to be able to prevent COVID-19 infection from the novel coronavirus by targeting both the spike protein on SARS-CoV-2, as well as the angiotensin converting enzyme 2 (ACE2) receptor that it binds to on human cells. The study was led by neuroscientists Thomas J. “TJ”

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Delveinsight

JANUARY 28, 2021

Nirogy plans to use the proceeds to improve its drug discovery platform for generating a pipeline of small-molecule drugs designed to aim the solute carrier family of transporter proteins (SLCTs) embedded in the cell membrane. Iterum Therapeutics presents new drug application to FDA for Oral Sulopenem.

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Pharmaceutical Technology

MARCH 10, 2023

Pharmaceutical and biotechnology industries widely use freeze-drying systems to protect vaccines, antibodies, antibiotics such as penicillin, blood plasma, proteins, enzymes, hormones, viruses, and bacteria from heat and minimise their biological activity.

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Roots Analysis

OCTOBER 19, 2023

Bacteria plays a crucial role in maintaining the ecosystem balance. However, there are few species of bacteria that can cause several infectious diseases ( such as strep throat, salmonellosis, tuberculosis, whooping cough ). The overuse of antibiotics has resulted in the emergence of multi-drug-resistant bacteria.

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Delveinsight

JULY 26, 2021

Some of the most commonly prescribed antibiotics in the Uncomplicated Urinary Tract Infection therapy market include the combination drug trimethoprim and sulfamethoxazole, trimethoprim, ?-lactams, Besides Gepotidacin, GSK is also evaluating another asset GSK3882347 , that targets an adhesive protein found on the surface of E.

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XTalks

DECEMBER 12, 2023

After receiving US Food and Drug Administration (FDA) approval for Fabhalta (iptacopan) last week for the treatment of the rare blood disorder paroxysmal nocturnal hemoglobinuria (PNH), Novartis presented trial data yesterday showing the drug’s promise in another indication.

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pharmaphorum

SEPTEMBER 14, 2020

While there may be just under 20,000 confirmed protein coding genes, it turns out that much of the genome outside of these genes is also important in regulating how the genome is controlled. On one hand, unfortunately this means that many drugs are doomed to failure. Now, however, the field is changing with respect to genomic medicine.

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Roots Analysis

FEBRUARY 27, 2024

On November 1, 2019, Avacta Group and ADC Therapeutics have announced a collaboration agreement for the development of novel drug candidates. The firm also has the right to obtain exclusive licenses to the Affimer proteins for clinical development and commercialization.

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The Pharma Data

JANUARY 13, 2021

13, 2021 — The bacteria in your gut may play a role in the severity of COVID-19 infection and the strength of your immune system response, a new study suggests. “Restoration of the missing beneficial bacteria might boost our immunity against SARS-CoV2 virus and hasten recovery from the disease,” she said.

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pharmaphorum

OCTOBER 27, 2021

Eli Lilly has followed through on its plan to file for approval of its Alzheimer’s disease candidate donanemab, and is planning to take on Biogen and Eisai with a head-to-head trial against their recently-approved Aduhelm drug. Cortexyme trial disappoints. gingivalis detectable in their saliva at the start of the trial.

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pharmaphorum

AUGUST 7, 2020

Biogen has bought a licence to co-develop and co-market potential Parkinson’s disease drugs with US biotech Denali, in a deal worth more than $2.1 LRRK2 regulates lysosomes, which play a vital role in cell function by breaking down excess or worn-out cell parts, and can also destroy invading viruses and bacteria.

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The Pharma Data

DECEMBER 31, 2020

People with severe COVID-19 have low proportions of antibodies that target the spike protein. In milder cases, the antibodies seem to do a better job of binding to the spike protein. The spike protein binds to the ACE2 receptor on human cells, which allows the virus to enter the cell.

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XTalks

OCTOBER 14, 2022

This week, GSK announced in a press release that the US Food and Drug Administration (FDA) had approved Boostrix as an immunization for pregnant women for the prevention of whooping cough in newborn infants. Whooping cough , also known as pertussis, is a highly contagious respiratory infection caused by the Bordetella pertussis bacteria.

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XTalks

AUGUST 2, 2022

On July 27, 2022, GSK announced that the US Food and Drug Administration (FDA) has approved Benlysta (belimumab) as an intravenous treatment for lupus and active lupus nephritis (LN) in children between the ages of 5 and 17 who are receiving standard therapy. When this behaviour is prolonged, it results in inflammation.

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Roots Analysis

JANUARY 14, 2024

With the increased interest and gradual shift of investment from small molecule drugs to biologics and the establishment of several biologics manufacturing companies / biologics CMOs, more than 250 biologic therapies and vaccines have been developed, globally. Like all drugs, biologics are regulated by the FDA.

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XTalks

JULY 25, 2023

Emergent BioSolutions, a multinational specialty biopharmaceutical company headquartered in Gaithersburg, Maryland, has achieved a significant milestone with the approval of its Cyfendus (Anthrax Vaccine Adsorbed, Adjuvanted) vaccine by the US Food and Drug Administration (FDA). Anthrax is a rare, yet severe disease caused by the bacterium B.

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The Pharma Data

MARCH 8, 2021

This investigational multivalent protein subunit vaccine targets the outer surface protein A (OspA) of Borrelia, an established mechanism of action for a Lyme disease vaccine. OspA is one of the most dominant surface proteins expressed by the bacteria when present in a tick. burgdorferi naïve volunteers.

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The Pharma Data

JUNE 22, 2023

They have shown that the mechanism involves a block in proteins called interferons, which promote tissue factor releases. ” The team demonstrated that life-threatening clotting could be prevented in mice infected with the bacteria E. coli and Staph aureus and also in response to SARS-CoV2, the virus that causes COVID-19.

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XTalks

APRIL 12, 2021

In 2019, Xtalks profiled six Parkinson’s biotech companies that were leading the way in disease research and drug development. In July of 2019, PR001 was granted Fast Track Designation from the US Food and Drug Administration (FDA), and the company’s composition of matter patent for PR001 was approved in November 2020.

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Roots Analysis

OCTOBER 16, 2023

Biopharmaceutical filtration is a critical step in the production of biopharmaceuticals, including proteins, antibodies, and vaccines. Membrane Filters: Membrane filters are typically used for sterilization and removal of smaller impurities such as bacteria and viruses. are used to remove any residual bacteria, viruses, or endotoxins.

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Delveinsight

JULY 23, 2020

Olema Oncology will assess the drug, a complete estrogen receptor antagonist, in patients with ER-positive, HER2-negative breast cancers that have come back despite other treatments or that have spread locally or to other parts of the body. The capital will bankroll a phase 1/2 study of the asset, OP-1250, as a single agent.

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Pfizer

FEBRUARY 16, 2023

Food and Drug Administration (FDA) and Marketing Authorisation Application (MAA) to the European Medicines Agency (EMA) in 2025, pending successful completion of the Phase 3 studies and subject to the agreement of these regulatory agencies to proposed modifications of the clinical trial plan. FDA in July 2017.

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The Pharma Data

JULY 21, 2021

This investigational multivalent protein subunit vaccine uses an established mechanism of action for a Lyme disease vaccine that targets the outer surface protein A (OspA) of Borrelia burgdorferi , the bacteria that cause Lyme disease. Food and Drug Administration (FDA) in July 2017 3. About Lyme Disease.

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The Pharma Data

APRIL 22, 2023

Plasma cells produce antibodies that protect the body from invasive foreign substances, such as bacteria and viruses. When transforming into cancerous myeloma cells, however, plasma cells continue to produce monoclonal immunoglobulin (M protein) that is not capable of attacking the foreign substances.

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Druggist

SEPTEMBER 15, 2021

This medicine inhibits the growth of bacteria by inhibiting the synthesis of essential proteins which is needed by the bacteria to carry out the necessary functions. This drug has been effective against other viruses such as Ebola and Zika. An ICMR official warned about the use of this drug in the year 2020.

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Druggist

SEPTEMBER 15, 2021

This medicine inhibits the growth of bacteria by inhibiting the synthesis of essential proteins which is needed by the bacteria to carry out the necessary functions. This drug has been effective against other viruses such as Ebola and Zika. An ICMR official warned about the use of this drug in the year 2020.

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The Pharma Data

OCTOBER 14, 2020

The AOP Orphan Group manufactures 80% of its drugs in Europe and has more than 20 subsidiaries and representative offices across the whole of Europe as well as in the United Arab Emirates and Israel. Food and Drug Administration granted Breakthrough Therapy designation to France-based Inventiva’s experimental NASH treatment lanifibranor.

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Delveinsight

FEBRUARY 18, 2021

Like troops at the forefront of any battle, our immune system continually marches to protect us from foreign elements and invaders, including bacteria, viruses, and others. During the whole process, Fibrinogen, the most abundant protein of the blood plasma after albumin and immunoglobulins, gets converted into insoluble protein fibrin.

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XTalks

AUGUST 2, 2023

Pfizer’s Top 5 Best-Selling Drugs of 2022: 1) Comirnaty Comirnaty is an mRNA-based vaccine indicated for the prevention of COVID-19. Comirnaty was first approved by the US Food and Drug Administration (FDA) in August 2021 for individuals over the age of 16. billion the drug generated in 2021. billion in 2022. billion, a 26.55

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XTalks

FEBRUARY 11, 2021

The drugmaker is targeting various steps in the manufacturing process, beginning right at the DNA stage, which is required as the template from which the mRNA for the SARS-CoV-2 spike protein in the vaccine is made. coli bacteria. The bacteria are grown in large vats, with the process taking two weeks.

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The Pharma Data

OCTOBER 19, 2020

In a challenge trial, people are given a vaccine then intentionally dosed with the virus or bacteria that causes the disease. The vaccine candidate is called “spike ferritin nanoparticle” (SpFN) and uses ferritin— “attaching a certain type of spike protein to a polymerized version of ferritin,” according to the organization.

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Roots Analysis

AUGUST 31, 2023

coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium. Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. When activator binds to the operon, it either speeds up or permits gene expression.

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XTalks

DECEMBER 22, 2021

RNA, and its protein-generating form messenger RNA (mRNA) discovered in 1961 , has quickly transitioned from being an obscure, finicky molecule that is difficult to work with, to becoming a significant cornerstone of therapeutic innovation in pharma and biotech. The RNA Revolution: From mRNA Vaccines to RNA Editing. RNA Therapeutics.

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The Pharma Data

JULY 18, 2021

Food and Drug Administration (FDA) approved VAXNEUVANCE ™ (Pneumococcal 15-valent Conjugate Vaccine) (pronounced VAKS-noo-vans) for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F and 33F in adults 18 years of age and older. “The

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The Pharma Data

DECEMBER 15, 2020

Many drug makers are investing in new science and hope to develop new therapeutics that address autoimmune disease. Scientists will be testing a drug class targeting the C-reactive protein (CRP) marker of acute inflammation in the body. They’ll use software that searches available drugs, as well as drug-like compounds.

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The Pharma Data

OCTOBER 26, 2020

AR-711 exhibits high affinity for SARS-CoV-2 spike protein, approximately 10-fold or higher than mAb candidates currently in late stage clinical testing. AR-701 is a cocktail of fully human mAbs discovered from convalescent COVID-19 patients that are directed at multiple envelope proteins of the SARS-CoV-2 virus. AR-701 (COVID-19).

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