Scienmag

JUNE 24, 2021

NIH scientists discover that bacteria may drive activity of many hallmark aging genes in flies Credit: Courtesy of the Giniger lab NIH/NINDS.

Scientist 72

Scientist Gene Bacteria Research 72

Scienmag

MAY 12, 2022

BIRMINGHAM, Ala. – Lei Zhang, Ph.D., and Michael Niederweis, Ph.D., of the University of Alabama at Birmingham have made what they call “a major step” in understanding how Mycobacterium tuberculosis acquires iron from its human host — a process essential for the pathogenesis of this bacterium.

Bacteria 84

Bacteria Bacterium Gene Medicine 84

Medical Xpress

DECEMBER 7, 2022

Researchers aiming to predict which staph-infection patients might develop a related kidney disease have found a high frequency of gene mutations in the infecting bacteria of affected patients, which suggests these variants may play a role in the body's initiation of the renal damage.

Gene 75

Gene Bacteria Development Research 75

Scienmag

JANUARY 8, 2021

Now research reveals that bacteria too have internal clocks that align with the 24-hour cycle of life on Earth. Credit: Professor Ákos Kovács, Technical University of Denmark Humans have them, so do other animals and plants.

Bacteria 66

Bacteria Drug Delivery Research Drugs 66

Scienmag

FEBRUARY 5, 2021

Membrane-localized phage proteins may also help revitalize, enhance existing antibiotics A study from the Center for Phage Technology, part of Texas A&M’s College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the “hidden” genes in bacteriophages — types of viruses that infect and destroy (..)

Gene 74

Gene Bacteria Life Science Development 74

Scienmag

JULY 1, 2022

One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Researchers have found that in bacteria DNA methylation plays a role in regulating virulence, reproduction and gene […].

Regulation 63

Regulation Gene DNA Bacteria 63

Pharmaceutical Technology

DECEMBER 14, 2022

Bacteria naturally develop resistance to antibiotics over time, through genetic mutation, horizontal gene transfer between bacteria, or because of selective pressure. Virus versus bacteria. Phages are viruses of bacteria. Secondly, the relationships between phages and bacteria are very specific.

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Bacteria DNA Clinical Trials Clinical Trials 130

Medical Xpress

JANUARY 4, 2023

Like humans, bacteria and archaea can be attacked by viruses. Bacterial defenses, such as CRISPR-Cas systems, have diverse proteins and functions that help bacteria protect themselves against foreign invaders. These microorganisms have developed their own immune defense strategies against their pathogens.

Bacteria 74

Bacteria Gene Research Protein 74

Scienmag

JUNE 21, 2022

The last two decades have seen the development of sophisticated computational tools that explore the DNA of bacteria. These tools are on the lookout for interesting metabolites (metabolism-related molecules) that illicit a strong biological reaction.

Bacteria 86

Bacteria DNA Gene Development 86

Scienmag

SEPTEMBER 30, 2021

Legumes engage in a unique and beneficial interaction with a group of soil bacteria, collectively called rhizobia. Crop legumes are an integral part of sustainable agriculture, as several of these species represent an important protein source for both human and animal populations.

Gene Expression 80

Gene Expression Bacteria Gene Protein 80

Scienmag

DECEMBER 18, 2020

Bacteria often show very strong biogeography – some bacteria are abundant in specific locations while absent from others – leading to major questions when applying microbiology to therapeutics or probiotics: how […].

Bacteria 52

Bacteria Genome Genomics Research 52

Scienmag

SEPTEMBER 23, 2020

In mice, the maternal gut microbiata regulates which genes are activated in the growing brain, UCLA study shows Credit: Reed Hutchinson/UCLA During pregnancy in mice, the billions of bacteria and other microbes that live in a mother’s intestines regulate key metabolites, small molecules that are important for healthy fetal brain development, (..)

Bacteria 92

Bacteria Regulation Gene Development 92

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Using Bacteria For Therapy. ” The Ideal Bacteria.

Bacteria 52

Bacteria Engineer Drugs Research 52

Scienmag

JANUARY 12, 2021

Martins Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics. The John Innes Centre researchers used the technology to create a new strain of Streptomyces formicae bacteria which over-produces the medically promising molecules. Credit: Dr Dino J.

Gene Editing 53

Gene Editing Gene Bacteria Scientist 53

pharmaphorum

OCTOBER 7, 2020

Drs Emmanuelle Charpentier and Jennifer Doudna have won this year’s Nobel Prize for chemistry in recognition of their work on the gene-editing technology CRISPR/Cas9. Charpentier’s early work in this area led to the discovery of tracrRNA, a previously unknown molecule that defends bacteria from viruses by cleaving their DNA.

Gene Editing 105

Gene Editing Bacteria DNA Gene 105

BioSpace

JANUARY 19, 2021

A naturally occurring system for tuning CRISPR-Cas9 expressing in bacteria, identified in a study published in Cell, could have implications for gene editing therapies as well.

Gene Editing 71

Gene Editing Bacteria Research Gene 71

BioTech 365

APRIL 5, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: DNA methylation from bacteria and microbiome using nanopore technology.Bacterial DNA methylation occurs in diverse sequence contexts and plays important functional roles in cellular defense and gene regulation.

Bacteria 40

Bacteria DNA Gene Regulation 40

Scienmag

SEPTEMBER 30, 2021

The microbiomes of corals — which comprise bacteria, fungi and viruses — play an important role in the ability of corals to tolerate rising ocean temperatures, according to new research led by Penn State. The team also identified several genes within certain corals and the symbiotic photosynthetic algae that live inside […].

Bacteria 69

Bacteria Gene Research 69

Pharmaceutical Technology

FEBRUARY 15, 2023

Innovation S-curve for the pharmaceutical industry CRISPR nuclease is a key innovation area in pharmaceutical development CRISPR, which refers to clustered regularly interspaced short palindromic repeats, are bacteriophage-derived DNA sequences that had previously infected the prokaryote and are found in the genomes of bacteria and archaea.

In-Vivo 162

In-Vivo Genome Genomics Gene Editing 162

Scienmag

JUNE 7, 2021

Travellers abroad may pick up bacteria and other vectors containing genes conferring antimicrobial resistance which remain in the gut when returning to their home country, according to a study published in Genome Medicine.

Gene 40

Gene Bacteria Genome Genomics 40

Scienmag

MAY 18, 2021

Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome.

Bacteria 74

Bacteria Genetics Scientist Gene 74

Scienmag

MAY 26, 2022

A new antibiotic, synthesized at The Rockefeller University and derived from computer models of bacterial gene products, appears to neutralize even drug-resistant bacteria. The compound, named cilagicin, works well in mice and employs a novel mechanism to attack MRSA, C.

Bacteria 63

Bacteria Drugs Gene Production 63

Scienmag

NOVEMBER 9, 2020

Princeton researchers have discovered a new protein involved in assembly and maintenance of the outer membrane of Gram-negative bacteria Credit: Silhavy Lab, Princeton University Bacteria are single-celled organisms that are essential to human health, both in our environment and inside our own bodies.

Bacteria 78

Bacteria Research Protein Gene 78

Roots Analysis

OCTOBER 19, 2023

Bacteria plays a crucial role in maintaining the ecosystem balance. However, there are few species of bacteria that can cause several infectious diseases ( such as strep throat, salmonellosis, tuberculosis, whooping cough ). The overuse of antibiotics has resulted in the emergence of multi-drug-resistant bacteria. coli and P.

Bacteria 40

Bacteria Production In-Vivo In-Vitro 40

pharmaphorum

SEPTEMBER 14, 2020

While there may be just under 20,000 confirmed protein coding genes, it turns out that much of the genome outside of these genes is also important in regulating how the genome is controlled. For example, we know that not all genes are expressed in all tissues and that not all genes are expressed during all developmental stages.”.

Genome 119

Genome Genomics Medicine Gene 119

Roots Analysis

AUGUST 31, 2023

Overview of Gene Switch The notion that genes might be turned on and off was discovered several decades ago when studies revealed that E. coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

XTalks

AUGUST 26, 2020

Macrophages are white blood cells that specialize in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In other words, when fighting bacteria, the macrophages are programmed to be pro-inflammatory. However, when they are programmed to be anti-inflammatory, they can help decrease inflammation.

Bacteria 105

Bacteria Immune Response Protein Medicine 105

Scienmag

AUGUST 17, 2020

Credit: Professor Mark Schembri There is new hope for approximately 700,000 people who die each year from antibiotic resistant infections, with University of Queensland researchers discovering how bacteria share antibiotic-resistance genes. “The diminishing […].

Bacteria 52

Bacteria Gene Research Genetics 52

The Pharma Data

JANUARY 19, 2021

A naturally occurring system for tuning CRISPR-Cas9 expressing in bacteria, identified in a study published in Cell , could have implications for gene editing therapies as well. A CRISPR-Cas9 system has two components: the Cas9 guide RNA that directs the system to edit a particular gene, and the CRISPR “scissors” that make the cut.

Bacteria 52

Bacteria Gene Editing Research RNA 52

Roots Analysis

OCTOBER 16, 2023

DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence. There are some motifs, such as hairpin loops which hinder the usability of a gene.

DNA 40

DNA Gene Protein In-Vitro 40

XTalks

NOVEMBER 9, 2021

RNAi precisely targets, then turns off, specific genes inside a cell. Because they would target genes specific to individual species, there’s a much lower chance that other organisms would get caught in the crossfire. It is a powerful technique that has many possible uses in biotechnology, medicine and, now, pesticides.

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RNA Gene Scientist Protein 98

BioTech 365

MARCH 16, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists reveal new mechanism of xenogeneic silencing in bacteria.Lateral gene transfer (LGT) plays a prominent role in the genome evolution and environmental adaptation of prokaryotes.

Scientist 40

Scientist Bacteria Genome Genomics 40

Scienmag

FEBRUARY 19, 2021

Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible.

Production 49

Production Bacteria Gene Development 49

Scienmag

JULY 16, 2021

Credit: Vaughn Cooper PITTSBURGH, July 16, 2021 – For the first time ever, researchers from the University of Pittsburgh School of Medicine discovered that phages–tiny viruses that attack bacteria–are key to initiating rapid bacterial evolution leading to the emergence of treatment-resistant “superbugs.”

Research 73

Research Bacteria Medicine Bioinformatics 73

XTalks

DECEMBER 12, 2023

PNH is caused by a mutation in the CFB gene that codes for complement factor B, a component of the alternative pathway of complement activation. Mutations in the gene result in the production of red blood cells that are prone to premature destruction (hemolysis).

FDA Approval 95

FDA Approval Bacteria Trials Protein 95

pharmaphorum

APRIL 23, 2021

CRISPR Therapeutics is to receive a hefty $900m payment from Vertex after the companies amended a collaboration to develop, manufacture and market a gene editing therapy for sickle cell disease and beta thalassemia.

Gene Editing 64

Gene Editing Gene DNA Bacteria 64

XTalks

APRIL 12, 2021

Read on to learn about the latest updates from Parkinson’s biotech companies Prevail Therapeutics, Axovant Gene Therapies, Voyager Therapeutics, Inflazome, Denali Therapeutics and Neuropore Therapies, and also find out about some emerging players in the Parkinson’s disease space. Axovant Gene Therapies. Prevail Therapeutics.

Gene Therapy 96

Gene Therapy Gene Trials Development 96