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Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. But the bacteria can sometimes change their behavior and enter the bloodstream, causing chronic localized infections to become acute and potentially fatal. aeruginosa infections.
Overview of Gene Switch The notion that genes might be turned on and off was discovered several decades ago when studies revealed that E. coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium.
We are talking about the microbiome – the vast collection of bacteria in the human gut. The microbiome has been the focus of research for 20 years – ever since a new technique made it possible to analyse these bacteria quickly and precisely: high-throughput sequencing. In doing so, they induce epigenetic changes.
Like all drugs, biologics are regulated by the FDA. Usually, the desired gene, such as human insulin gene, when inserted into the plasmid of the host cell uses transcriptional and translational machinery of the host to express itself. Examples of prominent microbial expression systems are bacteria, fungi, and yeast.
BioNTech/Pfizer’s vaccine became the world’s first approved COVID-19 vaccine, with UK regulators becoming the first to authorize it for emergency use, followed by Health Canada, which fully approved it. By re-tooling it, they were able to develop CRISPR/Cas9, a precision gene editing technology that can be used in any living organism.
It’s because certain genes act one way on some people… and another way on other people. Putting this in medical jargon, the gene ‘expresses’ one way with Bob, for example, and a completely different way with Mary. How a geneexpresses – that is, how the gene affects you – goes on to determine whether you get ill or not.
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