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Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. GeneExpression Considerations.
With the increased interest and gradual shift of investment from small molecule drugs to biologics and the establishment of several biologics manufacturing companies / biologics CMOs, more than 250 biologic therapies and vaccines have been developed, globally. Examples of prominent microbial expression systems are bacteria, fungi, and yeast.
In his laudatory speech, Werner Baumann, Chairman of the Board of Management of Bayer, emphasized the importance of science and transparency in research: “In record time – much quicker than even the most optimistic observers dared to hope – scientists were able to develop various vaccines against the virus.
From isolating SARS-CoV-2 in early January to sequencing its genome shortly thereafter and having a prototype vaccine against it within days, scientific process and progress have held steadfast throughout the pandemic. For example, investment in mRNA vaccines and viral vectors came well before January, many years before it.
It’s because certain genes act one way on some people… and another way on other people. Putting this in medical jargon, the gene ‘expresses’ one way with Bob, for example, and a completely different way with Mary. How a geneexpresses – that is, how the gene affects you – goes on to determine whether you get ill or not.
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