Remove Bacteria Remove Gene Remove Genetics Remove Immune Response
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Gene Therapy and Pharmacokinetics

Camargo

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. Gene Therapy Definition.

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Harnessing the microbiome: The new frontier in drug discovery and testing 

Drug Discovery World

Paul Denslow , CEO, Intus Bio, discusses how a new approach to tracking gut bacteria can revolutionse our understanding of the microbiome and bring about new discoveries for therapeutics. It’s a long-held doctrine that there’s no effective method to track the microbiome during drug research and development.

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Understanding the microbiome as an ‘overlooked critical organ’

pharmaphorum

Research into the area is being made possible through advancements in technology, such as being able to sequence genes at scale, allowing researchers to gain more detailed genetic data on the microbiome. Compelling advantages.

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Mouse study findings suggest new approach to treating Alzheimer’s 

Drug Discovery World

Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage. The mice were genetically modified to express a mutant form of the human brain protein tau, which builds up and causes damage to neurons and atrophy of their brains by nine months of age.

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The evolution of assays for immuno-oncology research

Drug Discovery World

Cancer is a complex heterogenous multistep disease characterised by uncontrolled cell proliferation combined with a dysregulated immune response. A healthy immune system is naturally primed to eliminate malignant and abnormal cells through a synchronised and dynamic interplay between adaptive and innate immunity.

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Research Roundup: Blood Test for Severe COVID-19 and More

The Pharma Data

They found an unusual result—the most frequently mutated ALS genes found in general populations were typically not affected in Malta ALS patients. Specifically, the Malta patients did not have mutations in the C9orf72, SOD1, TARDBP and FUS genes. How Some Prostate Cancer Cells Become Resistant to Treatment.