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Discover how Synlogic Inc's patented genetically engineered bacteria produce short-chain fatty acids to combat metabolic diseases. Learn more about this innovative treatment approach.
Discover how Synlogic Inc's patented genetically programmed microorganisms can modulate and treat diseases. Learn about the innovative method for producing pharmaceutical compositions using non-pathogenic bacteria to metabolize phenylalanine. Explore the potential applications in gut microbiome and tumor environments.
The New York biotech will invest in and develop up to three drugs with Gensaic, an emerging startup aiming to use the viruses that infect bacteria to deliver genetic medicines.
A study published in Nature on July 30, 2020 states that good bacteria living in our gut can do much more than just help digest food and boost our immune system. According to studies conducted by researchers at Cincinnati Children’s Hospital, the bacteria can help heal damaged intestinal tissues.
A genetic study analyzing the microbiome (bacteria in the gut) of a large nationally representative sample of the Finnish population finds that geographic, demographic, diet, and lifestyle factors are driving the spread of antibiotic resistance in the general population.
Changes in a single gene open the door for harmful gut bacteria to set off the inflammation that drives Crohn's disease, according to a new study led by Weill Cornell Medicine and NewYork-Presbyterian investigators. These findings could one day help doctors better select targeted treatments for patients with this immune disorder.
At a far distant point in Earth’s ancient past, two separate, single-celled life forms — an archaeon and a bacteria — became one in an act either of symbiosis or enslavement, depending on which microbiologist you ask. These capsule-shaped organelles don’t just turn oxygen and nutrients into chemical energy.
Bacteria integrate genetic material from other bacterial strains more easily than previously thought, which can lead to improved fitness and accelerated evolution. The team analysed genome transfer between bacteria of different lineages. This is shown in a recent study by biophysicists at the University of Cologne.
Combining discoveries in cancer immunology with sophisticated genetic engineering, Columbia University researchers have created a sort of "bacterial suicide squad" that targets tumors, attracting the host's own immune cells to the cancer to destroy it.
The technology of gene therapy is possible due to extensive DNA research and our resulting understanding of many diseases on the genetic level, and it encompasses several mechanisms such as introducing new genes (gene addition) and inactivating or replacing mutated genes (gene editing). Formulation Considerations.
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When Ravid Straussman, a cancer biologist at the Weizmann Institute of Science in Israel, looked deeper, he and several other research groups around the world found bacteria in the milieu of tumors. Read the rest…
Credit: RIKEN A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in experimentally evolving the common bacteria Escherichia coli under pressure from a large number of individual antibiotics. In doing so, they were able to identify the mechanisms and constraints underlying evolved drug resistance.
Credit: Surajit Chatterjee To better understand how RNA in bacteria gives rise to protein–and along the way, target these processes in the design of new antibiotics–researchers are turning their attention to the unique way this process happens in bacteria.
Credit: Jan Zrimec/Chalmers University of Technology Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans.
Credit: Avalos Lab/Princeton University Researchers at Princeton University have created a new and improved way to more precisely control genetically engineered bacteria: by simply switching the lights on and off. Working in E.
Now research reveals that bacteria too have internal clocks that align with the 24-hour cycle of life on Earth. Credit: Professor Ákos Kovács, Technical University of Denmark Humans have them, so do other animals and plants.
Researchers turn now to see how COVID-19 pandemic affected microbiome in each city Each city has its own unique microbiome, a “fingerprint” of viruses and bacteria that uniquely identify it, according to a new study from an international consortium of researchers that included a team from the University of Maryland School of Medicine (UMSOM). (..)
A new genetic approach can accelerate the study of phage-microbe interactions with implications for health, agriculture, and climate Credit: Wikimedia Commons Scientists are continually searching for new and improved ways to deal with bacteria, be it to eliminate disease-causing strains or to modify potentially beneficial strains.
The QIAstat-Dx Gastrointestinal Panel 2 Mini B&V uses QIAstat-Dxs real-time PCR technology to rapidly amplify multiple genetic targets within a single reaction. The panels ability to detect multiple pathogens in a single test will greatly enhance clinical decision-making, ensuring that patients receive appropriate and timely treatment.
Bacteria naturally develop resistance to antibiotics over time, through genetic mutation, horizontal gene transfer between bacteria, or because of selective pressure. Virus versus bacteria. Phages are viruses of bacteria. Secondly, the relationships between phages and bacteria are very specific.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Genetically engineered good bacteria could aid in combating disease.Our bodies are home to several bacterial species that help us maintain our health and wellbeing.
Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome.
Bacteria often show very strong biogeography – some bacteria are abundant in specific locations while absent from others – leading to major questions when applying microbiology to therapeutics or probiotics: how […].
In this video, we chat with health policy and drug pricing researcher Hussain Lalani; Julia Joung, a molecular biologist developing genetic screening technologies; and Avinash Manjula Basavanna, who researches engineered living materials and has developed a printable ink made from bacteria.
Process paves a road to safe, ethical, and fast drug manufacturing Credit: Rensselaer Polytechnic Institute TROY, N.Y. — Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals.
Study describes new mechanism for terminating transcription of DNA into RNA in bacteria Credit: Babitzke Laboratory and Dani Zemba, Penn State The protein, known as NusG, pauses the transcription machinery at specific DNA sequences to facilitate what is called “intrinsic termination” and prevent unwanted transcription that could disrupt (..)
Credit: Shutterstock Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics. The findings offer a potential new drug target in the search for effective new antibiotics as we face the growing threat of antimicrobial resistance (AMR) and infections caused by bacterial pathogens.
Kim New research suggests that the ability of green algae to eat bacteria is likely much more widespread than previously thought, a finding that could be crucial to environmental and climate science. New study points to potential widespread phagocytosis among green algae, suggests improved methodology in environmental microbiology Credit: N.
Originally discovered in bacteria as a defense mechanism against pathogens, CRISP/Cas9 has made it possible to make exquisitely detailed and precise alterations to DNA sequences on demand, and as a tool for molecular biology has already transformed research into diseases and drug discovery. What started as a curiosity?driven,
The spread of antibiotic resistant bacteria in hospitals could be greatly reduced thanks to research by The University of Queensland and Queensland Health.
A new study has found that a novel T cell genetically engineered by University of Arizona Health Sciences researchers is able to target and attack pathogenic T cells that cause Type 1 diabetes, which could lead to new immunotherapy treatments.
Cancer is often seen as a disease that arises from genetic mutations causing cells to divide uncontrollably and invade other parts of the body. Immune cells spread from lymph nodes to sites of infection to attack the invading bacteria. But the spread of cells away from their origins is actually a normal process in some cases.
Fortunately, there were already multiple strains of bacteria that infected and killed these insects. Why not learn from the best? Continue to STAT+ to read the full story…
Ella, 28, was diagnosed with cystic fibrosis – a rare genetic disease which causes a build-up of thick, sticky mucus in the lungs, digestive tract, and sinuses – at 18 months old. This sticky mucus gets trapped and breeds infections from bacteria I inhale,” says Ella, who adds she was “terrified” of doctors as a child.
Princeton researchers have discovered a new protein involved in assembly and maintenance of the outer membrane of Gram-negative bacteria Credit: Silhavy Lab, Princeton University Bacteria are single-celled organisms that are essential to human health, both in our environment and inside our own bodies.
Bacteria plays a crucial role in maintaining the ecosystem balance. However, there are few species of bacteria that can cause several infectious diseases ( such as strep throat, salmonellosis, tuberculosis, whooping cough ). The overuse of antibiotics has resulted in the emergence of multi-drug-resistant bacteria. coli and P.
Like humans, bacteria and archaea can be attacked by viruses. Bacterial defenses, such as CRISPR-Cas systems, have diverse proteins and functions that help bacteria protect themselves against foreign invaders. These microorganisms have developed their own immune defense strategies against their pathogens.
The shortlist includes researchers who elucidated how cells make energy, those who discovered the chemical chatter of bacteria, many of the brilliant minds who shepherded us into the “ era of the genome ,” and most prominently, the pioneers behind the mRNA Covid vaccines. Read the rest…
Bacterial toxins that cause mutations in surviving cells profoundly shape bacterial diversity and could contribute to antibiotic resistance A toxin produced by bacteria as a defence mechanism causes mutations in target bacteria that could help them survive, according to a study published today in eLife.
It’s a new genetic way of potentially targeting these really hard to treat diseases,” said Abudayyeh, a McGovern Fellow at MIT’s McGovern Institute for Brain Research, in MIT’s press release. Integrases are used by viruses called bacteriophages to insert their genetic material into bacteria. percent of these cells.
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