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Credit: Surajit Chatterjee To better understand how RNA in bacteria gives rise to protein–and along the way, target these processes in the design of new antibiotics–researchers are turning their attention to the unique way this process happens in bacteria.
Lyme disease is also known as borreliosis, which refers to the borrelia bacteria that cause the condition. The vaccine targets six different serotypes of borrelia bacteria. In the past, the volatility of the bacteria made target identification difficult. It is currently treated with antibiotics.
When exposed to stress, bacteria allow their metabolism to take a break during which they suppress, for example, the incorporation of proteins into membranes. Scientists from Marburg, Freiburg and Munich have discovered this by biochemically investigating the stress response of microorganisms.
CAMBRIDGE, MA — MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple antibiotics.
. – Researchers from the University of Louisville School of Dentistry and their colleagues have discovered details of how proteins produced by oral epithelial cells protect humans against viruses entering the body through the mouth. Credit: University […].
To counter this, bacteria can increase their internal solute concentration. Scientists from the University of Groningen elucidated the structure of a transport protein OpuA, that imports glycine betaine to counter […].
But several researchers and experts have brought to light some food safety concerns of plant-based meat, and why it must be treated differently than that of animal protein. Because of their near-neutral pH and high protein and moisture content, plant-based meats are susceptible to microbial growth. Subject to Microbial Growth.
Fortunately, there were already multiple strains of bacteria that infected and killed these insects. Why not learn from the best? Continue to STAT+ to read the full story…
Building the driving machinery of bacteria, the flagella, requires numerous proteins to be assembled. Credit: UNIGE/VIOLLIER To build the machinery that enables bacteria to swim, over 50 proteins have to be assembled according to a logic and well-defined […].
Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction, supports a mechanism critical for survival in mouse models of sepsis and colitis Credit: UC San Diego Health Sciences The immune response to infections is a delicate balance.
A geneticist from RUDN University studied the effect of Bifidobacterium (intestinal bacteria) on the inflammatory process and discovered that their surface protein is capable of stopping excessive or uncontrollable inflammation Credit: RUDN Univeristy A geneticist from RUDN University studied the effect of Bifidobacterium (intestinal bacteria) on the (..)
Variation in how animals and bacteria use heme reveals potential target for new antibiotics Credit: (Courtesy of Robert Kranz) It took an unlikely food innovation — earth-friendly vegetarian patties, made to taste and “bleed” like the familiar meaty ones — to make people aware of heme.
The immune system is a complex network of cells and proteins with a simple job. To do that, the cells must recognize and destroy infecting viruses or bacteria. BIRMINGHAM, Ala. – Defend the body against infection. In addition, the system also has to keep a record of each pathogen it has defeated, so it can […].
The findings, published in Science Translational Medicine, suggests that breaches in damaged gums allow bacteria in the mouth to seep into the bloodstream, activating an immune response that ultimately pivots to target the body's own proteins and causes arthritis flareups.
Many bacteria and unicellular algae have light-driven pumps in their cell membranes: proteins that change shape when exposed to photons such that they can transport charged atoms in or out of the cell. Thanks to these pumps, their unicellular owners can adjust to the environment’s pH value or salinity.
Renegade Creamery makes plant-based cheese but adds milk proteins produced in strains of yeast and bacteria and uses an “artisan fermentation process.” The company says that the whey-protein-producing microbes are “fed” plant-based inputs and the milk protein is collected following fermentation.
Simply put, an antibody is a large, Y-shaped blood protein produced by plasma cells that the immune system uses to take down pathogens like bacteria – and of course, viruses like SARS-CoV-2.
Hansen DALLAS – May 21, 2021 – One member of a large protein family that is known to stop the spread of bacterial infections by prompting infected human cells to self-destruct appears to kill the infectious bacteria instead, a new study led by UT Southwestern scientists shows. However, some bacteria have their […].
Princeton researchers have discovered a new protein involved in assembly and maintenance of the outer membrane of Gram-negative bacteria Credit: Silhavy Lab, Princeton University Bacteria are single-celled organisms that are essential to human health, both in our environment and inside our own bodies.
Like humans, bacteria and archaea can be attacked by viruses. Bacterial defenses, such as CRISPR-Cas systems, have diverse proteins and functions that help bacteria protect themselves against foreign invaders. These microorganisms have developed their own immune defense strategies against their pathogens.
This investigational multivalent protein subunit vaccine targets the outer surface protein A (OspA) of the bacterium Borrelia that causes the disease, an established mechanism of action for a Lyme disease vaccine.
Credit: Eric Koch Nearly every organism hosts a collection of symbiotic microbes–a microbiome. It is now recognized that microbiomes are major drivers of health in all animals, including humans, and that these symbiotic systems often exhibit strong daily rhythms.
Researchers from the Institute of Biotechnology at the Life Sciences Center of Vilnius University – Dalia Smalakyte, Audrone Rukšenaite, Dr Giedrius Sasnauskas, Dr Giedre Tamulaitiene, and Dr Gintautas Tamulaitis – have revealed the structure of the CRISPR-Cas "protein scissors" found in bacteria and provided mechanistic details on how they function. (..)
Crop legumes are an integral part of sustainable agriculture, as several of these species represent an important protein source for both human and animal populations. Legumes engage in a unique and beneficial interaction with a group of soil bacteria, collectively called rhizobia.
Veneno will carry out a programme to generate functional peptides (DRPs) for G protein-coupled receptors (GPCRs), which will be targeted by Astellas. Drug discovery company Veneno Technologies has signed a joint research agreement with Japanese pharmaceutical company Astellas Pharma.
Now, a first-of-its-kind Stanford University analysis evaluates the market potential of the approach, in which bacteria fed captured methane grow into protein-rich fishmeal. Like a mirage on the horizon, an innovative process for converting a potent greenhouse gas into a food security solution has been stalled by economic uncertainty.
An investigational orally delivered biologic drug, LMN-201 is a cocktail of four therapeutic proteins that act synergistically to neutralise the C difficile bacterium and the toxin. It is compatible with standard-of-care antibiotics. Pivotal trials on LMN-201 are expected to commence in 2023.
Macrophages are white blood cells that specialize in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In other words, when fighting bacteria, the macrophages are programmed to be pro-inflammatory. They found a protein called Rspondin3, which is released at high levels during inflammatory injury.
Potential new antibiotics work by disrupting bacterial membrane and summoning immune cells in animal models PHILADELPHIA–A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom.
Researchers from Skoltech, Lomonosov Moscow State University, and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key cell machinery, can be safely lost and why.
Membrane-localized phage proteins may also help revitalize, enhance existing antibiotics A study from the Center for Phage Technology, part of Texas A&M’s College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the “hidden” genes in bacteriophages — types of viruses that infect and destroy (..)
One nanobody in particular, called NIH-CoVnb-112, was shown to be able to prevent COVID-19 infection from the novel coronavirus by targeting both the spike protein on SARS-CoV-2, as well as the angiotensin converting enzyme 2 (ACE2) receptor that it binds to on human cells. The study was led by neuroscientists Thomas J. “TJ”
Bioinformatics: publication in Nature Communications The most important components for the functioning of a biological cell are its proteins. As a result, protein production is arguably the most important process for cell growth. The faster the bacterial growth rate, the faster protein synthesis needs to take place.
Separately, this process may produce odors as bacteria present on the skin break down sweat proteins. A deodorant kills the bacteria that produce the odor, while an antiperspirant clogs sweat […].
Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology. EAST LANSING, Mich.
Toxic protein inhibits cell wall synthesis in rival bacteria. Discovery helps explain how pathogens cause imbalances in established microbial communities and could pave the way to the development of novel anti-microbial compounds.
The key component in all vaccines is one or more active ingredients made from viruses or bacteria, also called antigens, which generates an immune response. The active component of the Pfizer-BioNTech vaccine tozinameran, contains the genetic code for the coronavirus spike protein, inside a lipid (fat) capsule.
Using only a small blood sample, the test detects a protein secreted by Mycobacterium tuberculosis, which causes TB infection Credit: Video by Carolyn Scofield, Tulane University School of Medicine Researchers at Tulane University School of Medicine have developed a highly sensitive blood test that can find traces of the bacteria that causes tuberculosis (..)
Nirogy plans to use the proceeds to improve its drug discovery platform for generating a pipeline of small-molecule drugs designed to aim the solute carrier family of transporter proteins (SLCTs) embedded in the cell membrane. Gut Bacteria proffer insight into molecules protective against asthma and COVID-19.
Study describes new mechanism for terminating transcription of DNA into RNA in bacteria Credit: Babitzke Laboratory and Dani Zemba, Penn State The protein, known as NusG, pauses the transcription machinery at specific DNA sequences to facilitate what is called “intrinsic termination” and prevent unwanted transcription that could disrupt (..)
Phytoplasma are a type of bacteria that live within the cells and cause devastating diseases with damaging effects. For example, in many cases plants infected with phytoplasma are no longer able to develop flowers.
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Atomic techniques reveal the evolution of a bacterial protein.Researchers show how bacteria have adapted a sensing mechanism that allows them to live in different environments.
The study results revolve around the immune system, the cells and proteins that destroy invading bacteria and viruses. A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows.
The innovative food packaging is made from a type of corn protein called zein , starch and other naturally-derived biopolymers, which have been found to be sustainable replacements for PFAS and other plastic-coated paper. The “smart” packaging kills harmful microbes and can extend the shelf life of fresh foods for multiple days.
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