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Radical Vaccine Strategy Could Help Quash Parasite Afflicting Millions

AuroBlog - Aurous Healthcare Clinical Trials blog

Using viruses that infect bacteria to detect proteins sprouted by a notorious parasite, scientists have honed in on possible vaccine targets for schistosomiasis, a neglected tropical disease that currently affects an estimated 600 million people worldwide, causing 280,000 deaths per year.

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How bacteria cope with stress

Scienmag

When exposed to stress, bacteria allow their metabolism to take a break during which they suppress, for example, the incorporation of proteins into membranes. Scientists from Marburg, Freiburg and Munich have discovered this by biochemically investigating the stress response of microorganisms.

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Dual brake on transport protein prevents cells from exploding

Scienmag

To counter this, bacteria can increase their internal solute concentration. Scientists from the University of Groningen elucidated the structure of a transport protein OpuA, that imports glycine betaine to counter […].

Protein 88
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Penn Medicine scientists engineer bacteria-killing molecules from wasp venom

Scienmag

Potential new antibiotics work by disrupting bacterial membrane and summoning immune cells in animal models PHILADELPHIA–A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom.

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New model for antibacterial mechanism

Scienmag

Department of Energy’s Brookhaven National Laboratory and their collaborators have discovered an aberrant protein that’s deadly to bacteria. In a paper just published in the journal PLOS ONE, the scientists describe how this erroneously built protein mimics the action of aminoglycosides, a class of antibiotics.

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The sweet spot of flagellar assembly

Scienmag

Building the driving machinery of bacteria, the flagella, requires numerous proteins to be assembled. Adding sugar and the presence of a control point are two key steps identified by UNIGE scientists.

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Immune protein orchestrates daily rhythm of squid-bacteria symbiotic relationship

Scienmag

New research led by University of Hawai’i at Manoa scientists revealed that, in the mutually beneficial […]. It is now recognized that microbiomes are major drivers of health in all animals, including humans, and that these symbiotic systems often exhibit strong daily rhythms.