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Pfizer will pay up to $45 million in development related milestone payments and up to $143 million if the vaccine hits early sales targets. VLA15 has demonstrated a promising immuneresponse and safety data in pre-clinical and clinical studies so far.
What’s more, VAX-24 achieved a higher immuneresponse to 16 of the 20 serotypes it shares with Prevnar 20. According to the UK’s National Health Service (NHS), there are over 90 strains of this bacterium. VAX-24 has forecasted sales of $21 million in the same year. billion and $812 million in 2028.
Compared to Vaxneuvance’s targeting of 15 different strains of the bacterium, Pfizer’s shot protects against 20. billion in sales in 2020 and has been outselling Merck’s previous shot, Pneumovax 23, by almost five to one. This is seven more strains than its current winning vaccine Prevnar 13, which registered $5.95
billion in sales last year. The pandemic and the timing of US government purchases for immunisation campaigns trimmed back sales from almost $5.9 The biotech says this can stimulate both B cell (antibody) and T cell immuneresponses with a single shot.
The bulk of Prevnar 13 sales come from use in adults, and with Merck & Co in the final stages of regulatory review of its rival vaccine V114 – covering 15 serotypes and filed for adult use – the franchise is facing some serious competition for the first time. That is equivalent to 14% of Pfizer’s total revenues.
” In the adult phase I/II clinical trials, AFX3772 was well tolerated in participants and demonstrated good immuneresponses compared to the current standard of care. New GSK reaffirms its full-year 2022 guidance and the medium-term outlook for 2021-2026 of more than 5% sales and 10% adjusted operating profit CAGR* at CER**.
In the adult phase I/II clinical trials, AFX3772 was well tolerated in participants and demonstrated good immuneresponses compared to the current standard of care. New GSK reaffirms its full-year 2022 guidance and the medium-term outlook for 2021-2026 of more than 5% sales and 10% adjusted operating profit CAGR* at CER**.
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