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Intended for intranasal administration, NGoXIM was demonstrated to be effective in animal models and elicited a durable and cross-protective immuneresponse in proof-of-concept (PoC) studies. . This trial will evaluate the safety of the vaccine and generate efficacy data.
Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The first healthy volunteer was dosed with the vaccine in Australia as part of the bacTRL-Spike COVID-19 Phase I clinical trial. COVID-19 Clinical Trials.
Valneva has said it plans to accelerate research into its Lyme disease vaccine candidate VLA15, bringing forward a trial including children into the first quarter of 2021. VLA15 has demonstrated a promising immuneresponse and safety data in pre-clinical and clinical studies so far.
Some gonorrhoea infections have become untreatable with all seven main antibiotic classes – a situation last encountered in the 1920s before the advent of effective drugs for the bacterium. At the moment most cases are treated with azithromycin, with intravenous ceftriaxone generally reserved as a last-line therapy.
Compared to Vaxneuvance’s targeting of 15 different strains of the bacterium, Pfizer’s shot protects against 20. While Merck’s previous shot, Pneumovax 23, defends against 23 serotypes and has been on the market for almost four decades, the immuneresponses it generates are not as durable as Prevnar 13.
What’s more, VAX-24 achieved a higher immuneresponse to 16 of the 20 serotypes it shares with Prevnar 20. According to the UK’s National Health Service (NHS), there are over 90 strains of this bacterium. VAX-24 met standard superiority criteria for four additional serotypes, as stated in the October 24 press release.
Update (November 11, 2020): Quebec-based biopharmaceutical company Medicago has announced positive results from a Phase I trial of its candidate plant-derived vaccine. Interim results of the trial show that all participants developed an antibody response after two doses of the COVID-19 adjuvanted vaccine candidate.
While diseases like celiac are associated with inappropriate activation of the immune system triggered by food antigens, this is not the case in IBS. In a normal, healthy intestine, foods do not trigger immuneresponses and so in a patient with IBS, something else must activate the response. Mouse and Human Studies.
The shot also includes two “conserved” pneumococcal proteins – antigens that seem always to be present in the bacterium regardless of its serotype, so could potentially provide protection against an even broader range.
” In the adult phase I/II clinical trials, AFX3772 was well tolerated in participants and demonstrated good immuneresponses compared to the current standard of care. Phase I/II clinical trials to assess the use of the vaccine in paediatrics are planned to begin later this year. About Pneumococcal disease.
In the adult phase I/II clinical trials, AFX3772 was well tolerated in participants and demonstrated good immuneresponses compared to the current standard of care. Phase I/II clinical trials to assess the use of the vaccine in paediatrics are planned to begin later this year. Pneumococcal disease.
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