Outsourcing Pharma

JULY 9, 2024

dsm-firmenich has announced the launch of CBtru â an advanced formulated cannabidiol (CBD) drug product intermediate designed for oral solid delivery formats.

Bioavailability 81

Bioavailability Development Drugs Production 81

Pharmaceutical Technology

JUNE 9, 2023

The water-free formulation of the investigational drug increases residual time on the surface of the eye and improves bioavailability in the target tissues to release the complete potential of cyclosporine A. CyclASol is topical anti-inflammatory and immunomodulating ophthalmic drug solution containing 0.1%

FDA Approval 246

FDA Approval Bioavailability Containment Drugs 246

XTalks

DECEMBER 4, 2024

Jotrol overcomes these barriers using patented micellar technology, enhancing bioavailability and enabling therapeutically effective doses. Conventional resveratrol products often face challenges like poor absorption and significant gastrointestinal side effects.

Bioavailability 111

Bioavailability Genetic Disease Marketing RNA 111

Pharmaceutical Technology

AUGUST 22, 2024

Discover Amneal Pharmaceuticals' innovative gastroretentive tablet patent, enhancing drug bioavailability and sustained release of pyridostigmine bromide for improved patient outcomes.

Bioavailability 100

Bioavailability Drugs 100

Drug Patent Watch

JUNE 17, 2024

Here are some key approaches with examples: New Formulations One common strategy is to develop and patent new formulations of the existing drug compound to provide benefits like reduced dosing frequency, easier administration, improved bioavailability, or reduced side effects. […] Source

Bioavailability 105

Bioavailability Drugs Development 105

BioTech 365

JANUARY 26, 2022

Global Drug Bioavailability Enhancement Summit 2022: Two Day Online Program – May 16-17, 2022 – ResearchAndMarkets.com Global Drug Bioavailability Enhancement Summit 2022: Two Day Online Program – May 16-17, 2022 – ResearchAndMarkets.com DUBLIN–(BUSINESS WIRE)–The “2022 Global Drug Bioavailability Enhancement (..)

Bioavailability 40

Bioavailability Drugs 40

Pharma Mirror

APRIL 8, 2022

CellCentric is developing inobrodib, an orally bioavailable drug that is transitioning into Phase II clinical trials in multiple indications. Both have stellar experience and track records in oncology research and development.

Bioavailability 130

Bioavailability Clinical Trials Clinical Trials Development 130

BioTech 365

OCTOBER 5, 2021

Global Peptide Therapeutics Markets, 2021-2026 – Increase Bioavailability of Drugs and Broaden Application of Peptides Therapeutics – ResearchAndMarkets.com Global Peptide Therapeutics Markets, 2021-2026 – Increase Bioavailability of Drugs and Broaden Application of Peptides Therapeutics – ResearchAndMarkets.com DUBLIN–(BUSINESS (..)

Bioavailability 40

Bioavailability Marketing Drugs 40

BioTech 365

APRIL 30, 2021

Outlook on the Microencapsulation Global Market to 2027 – Need to Reduce Capsule Size and Increase Bioavailability Presents Opportunities – ResearchAndMarkets.com Outlook on the Microencapsulation Global Market to 2027 – Need to Reduce Capsule Size and Increase Bioavailability Presents Opportunities … Continue reading → (..)

Bioavailability 40

Bioavailability Marketing 40

XTalks

NOVEMBER 6, 2024

The stable gel matrix holds multiple ingredients, offering targeted release and enhanced bioavailability while optimizing patient experience. Gelteq centers its technology on a proprietary, customizable gel platform designed for precise drug delivery, supporting prescription drugs, nutraceuticals, pet care and sports supplements.

Drug Delivery 104

Drug Delivery Drugs Bioequivalency Bioavailability 104

Camargo

FEBRUARY 10, 2021

The results of the population analysis reveal the average relative bioavailability of the test to reference. The comparison of relative bioavailability based on simulated data then indicates if BE can be achieved.

Production 133

Production Bioavailability In-Vivo In-Vitro 133

Outsourcing Pharma

AUGUST 8, 2022

The pharmaceutical company has forged a partnership with the nanotechnology specialist to use nanoparticle tech and formulation to advance its products.

Bioavailability 52

Bioavailability Branding Medicine Production 52

Pharmaceutical Technology

JANUARY 17, 2023

OR-449 is a first-in-class, orally bioavailable, potent and selective small molecule antagonist of the orphan nuclear receptor steroidogenic factor-1 (SF-1, NR5A1). SF-1 is an important transcription factor for adrenal gland growth and development.

Bioavailability 147

Bioavailability Clinical Trials Clinical Trials Clinical Development 147

BioTech 365

AUGUST 17, 2021

Alzamend Neuro Announces It Has Contracted With Altasciences to Conduct a Phase I Relative Bioavailability Study for AL001 for Dementia Related to Alzheimer’s Disease in September 2021 Alzamend Neuro Announces It Has Contracted With Altasciences to Conduct a Phase I … Continue reading →

Bioavailability 40

Bioavailability 40

XTalks

DECEMBER 5, 2022

Clinical-stage biotech company PureTech Health has announced it has developed a new oral CBD therapeutic candidate with improved bioavailability and tolerability, which could expand use of the CBD prodrug in a wide range of indications and age groups.

Bioavailability 97

Bioavailability FDA Approval Trials Drugs 97

Fierce Pharma

JULY 20, 2023

Eisai showed off "promising" results from a modeling and bioavailability study of its subcutaneous Leqembi formulation. After a recent study of Eisai's subcutaneous Leqembi formulation, the company is touting its "promising" results.

Bioavailability 79

Bioavailability 79

Pharmaceutical Technology

JUNE 13, 2023

“The development strategy with these dual mechanism compounds is for potential ‘fast follow-on’ drug candidates that can leverage the experience with istaroxime and provide the potential added feature of oral bioavailability for use as a treatment for chronic heart failure.

Bioavailability 130

Bioavailability Protein Drugs Development 130

Pharmaceutical Technology

AUGUST 10, 2022

The network comprises sites for the production of large-scale and controlled release oral solids in Winchester, Kentucky, development and manufacturing of softgel in St Petersburg, Florida, as well as other facilities with bioavailability enhancement technologies and platforms for oral solids production.

Packaging 147

Packaging Packaging Bioavailability Manufacturing 147

Pharmaceutical Technology

MAY 31, 2023

CFT8919 is an orally bioavailable BiDAC degrader designed to exhibit potent and selective activity against EGFR L858R in patients with non-small cell lung cancer (NSCLC). The agreement will cover the Hong Kong special administrative region (SAR), the Macau SAR and Taiwan.

In-Vivo 130

In-Vivo Bioavailability In-Vitro Licensing 130

Pharmaceutical Technology

MAY 18, 2023

It delivers sustained BTK protein inhibition by optimising bioavailability, half-life and selectivity. Brukinsa is a small molecule Bruton’s tyrosine kinase (BTK) inhibitor that will be used to treat chronic lymphocytic leukaemia (CLL) in adult patients.

Bioavailability 130

Bioavailability Protein Production 130

Pharmaceutical Technology

MAY 8, 2023

The small molecule Bruton’s tyrosine kinase (BTK) inhibitor Brukinsa has been specially designed for delivering sustained BTK protein inhibition by optimising bioavailability, half-life, and selectivity.

Bioavailability 130

Bioavailability Clinical Trials Clinical Trials Protein 130

Pharmaceutical Technology

MAY 2, 2023

The orally bioavailable small molecule EGFR inhibitor ERAS-801 demonstrated significant central nervous system (CNS) penetration in animal trials. This newly granted status helps Erasca to facilitate the development and review of ERAS-801, thereby accelerating the therapy’s reach to patients.

Bioavailability 130

Bioavailability Clinical Development Gene Trials 130

Pharmaceutical Technology

FEBRUARY 13, 2023

It is formulated using a self-micro-emulsifying drug delivery system that improves the drug’s bioavailability and solubility. Elyxyb is a prescription nonsteroidal anti-inflammatory drug (NSAID) used for acute migraine treatment in adult patients with or without aura.

Drug Delivery Systems 130

Drug Delivery Systems FDA Approval Bioavailability Drug Delivery 130

Pharmaceutical Technology

JANUARY 20, 2023

Brukinsa is a small-molecule Bruton’s tyrosine kinase (BTK) inhibitor specially designed for delivering sustained and targeted BTK protein inhibition by optimising bioavailability, half-life, and selectivity. The regulatory approval for the BTK inhibitor to treat CLL was based on Phase III SEQUOIA and ALPINE clinical trials.

Marketing 130

Marketing Bioavailability Trials Clinical Trials 130

Pharmaceutical Technology

AUGUST 30, 2022

Reduced solubility and low bioavailability affect a huge number of solid drug products, especially tablet formulations on the market. All the clinical and other development expenses will be handled by Insud. The firms are currently working on a second product candidate and plan to develop more products under the partnership.

Development 130

Development Drugs Bioavailability Production 130

BioSpace

JUNE 18, 2023

Jubilant Therapeutics's differentiated, orally bioavailable molecules address both validated and novel therapeutic targets in oncology and immunology.

Bioavailability 58

Bioavailability Medicine 58

Pharmaceutical Technology

APRIL 20, 2023

In the first phase of its training workshops, the Pharmaceutical Innovation Center plans to develop a range of excipients [inactive substances that serve as the vehicle or medium for a drug or other active substance] for controlled release dosage forms, improving their bioavailability, along with formulating orally dispersible and chewable tablets.

Bioavailability 130

Bioavailability Manufacturing Scientist Development 130

XTalks

FEBRUARY 5, 2025

The HALO platform enhances peptide half-life, facilitating monthly dosing and titration-free regimens, while the MOMENTUM platform optimizes oral bioavailability. Metseras HALO platform and MOMENTUM oral peptide delivery platform were used to develop these candidates. billion in 2024 to $37.94

Hormones 59

Hormones Bioavailability Clinical Trials Clinical Trials 59

Scienmag

MAY 21, 2022

By measuring the maximum concentration over time, the researchers found bioavailability of vitamin D […].

Bioavailability 58

Bioavailability Research 58

Outsourcing Pharma

JANUARY 24, 2023

Evidence shows that animal models currently dominating bioavailability estimates are poor predictors and human, cell-based multi-organ microphysiological systems (MPS) should be investigated, CN Bio says.

Bioavailability 52

Bioavailability Research Clinical Development Development 52

XTalks

JUNE 27, 2024

Therefore, techniques and technologies that promote drug solubility and bioavailability are in high demand. Their focus is on improving drug solubility and bioavailability with powerful amorphous dispersion technologies, such as KinetiSol for poorly soluble compounds.

Bioavailability 59

Bioavailability Manufacturing Drugs Development 59

XTalks

JANUARY 30, 2025

Improved bioavailability can lead to a faster onset of therapeutic effects, which is especially valuable in conditions where prompt action is required. Advanced formulation techniques are often required to improve the solubility and bioavailability of these APIs. Dosing flexibility is another prominent advantage provided by PDFs.

Manufacturing 52

Manufacturing Development Compliance Production 52

Pharmaceutical Technology

SEPTEMBER 23, 2022

GlobalData anticipates CyclASol to be positioned as the superior cyclosporine due to its favorable tolerability profile and better bioavailability, with the potential to capture market share from other cyclosporine-based therapies.

Development 147

Development Drugs Clinical Trials Clinical Trials 147

pharmaphorum

JULY 22, 2021

The company said other companies were also looking at the orally bioavailable drug, but Pfizer emerged as an ideal partner for ARV-371. Arvinas has previously signed PROTAC-based research collaborations with Bayer , Roche’s Genentech unit and Merck & Co/MSD although the latter deal expired last year.

Protein 116

Protein Hormones Bioavailability Drugs 116

pharmaphorum

MARCH 16, 2021

The platform lends itself to situations in which drug developers have too many antibody-antigen binding options to choose from and need to narrow down the field, as well as for projects in which getting binding antibodies is proving challenging, or where antibodies bind to a target but are deficient in other aspects such as bioavailability.

Antibody 101

Antibody Bioavailability Engineer Drugs 101

BioTech 365

SEPTEMBER 28, 2021

inhibitor, ART4215, is the first selective, orally bioavailable, small molecule inhibitor of the Pol? Artios Doses First Patient in Phase 1/2a Study of Pol? Inhibitor ART4215 Artios Doses First Patient in Phase 1/2a Study of Pol? Inhibitor ART4215 Pol? polymerase … Continue reading →

Bioavailability 40

Bioavailability 40

Camargo

AUGUST 22, 2021

3.1.1: Bioavailability Study Reports. The TRC for study data only apply to documents submitted with the metadata of “study report,” “pre-clinical study report,” and “legacy study report” in the Module 4 and Module 5 sections listed below: 2.3.1: Single-Dose Toxicity. 2.3.2: Repeat-Dose Toxicity. 2.3.4: Carcinogenicity.

Containment 190

Containment Bioavailability Cosmetics Packaging 190