XTalks

JUNE 14, 2023

Furthermore, the bioavailability of the active pharmaceutical ingredient (API) into the cornea is up to four times stronger with EyeSol technology. The solution of Vevye does not contain water, anti-microbial preservatives, oils or surfactants. Vevye (cyclosporine ophthalmic solution) 0.1

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Pharmaceutical Technology

MAY 10, 2023

Within the pharmaceutical industry, it is critical to measure particle size as it influences surface area and porosity, impacting a drug’s bioavailability, effectiveness, and shelf life. Alternatively, they can come as a product component of formulations such as cleaning agents and polymers.

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The Pharma Data

DECEMBER 29, 2020

Cybin is developing technologies and delivery systems, aiming to improve bioavailability, to potentially achieve the desired medicinal effects of psychedelics at low dosage levels. Cybin is a life sciences company advancing psychedelic pharmaceutical treatments for various psychiatric and neurological conditions.

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The Pharma Data

JANUARY 20, 2021

In addition to its potent local effect, another advantage of using this active substance is that it has very low bioavailability, i.e. around 90% of it is inactivated in the liver before it reaches the systemic circulation. Forward-Looking Statements. This information was brought to you by Cision [link].

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The Pharma Data

APRIL 7, 2023

This is a fine balance to achieve – if the compounds are too large, they may not pass through the cell membrane, and their bioavailability would be affected; if they are too small, they would not retain high specificity to the target protein (or proteins).

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The Pharma Data

MAY 14, 2021

The natural green tea contained by this formula, and the broccoli leaf extracts are also powerful ingredients. The Journal of Synthetic Chemistry confirms that broccoli leaf extracts have extremely powerful and valuable nutrients, ones that are required to maintain the good health of the prostate.

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Packaging Packaging Production Bioavailability 52

The Pharma Data

DECEMBER 8, 2020

Kura’s most advanced drug candidate is tipifarnib, a potent, selective and orally bioavailable farnesyl transferase inhibitor currently in a registration-directed trial (AIM-HN) in patients with recurrent or metastatic HRAS mutant head and neck squamous cell carcinoma. Forward-Looking Statements.

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The Pharma Data

NOVEMBER 19, 2020

These compounds have demonstrated high potency in inhibiting the activity of the M pro protease as well as promising oral bioavailability and blood plasma levels in animal studies. This press release contains forward-looking statements, including statements about the discovery, development and commercialization of products.

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Development Bioavailability Production Drugs 40

The Pharma Data

OCTOBER 21, 2020

We designed KB-0742 to be an orally bioavailable CDK9 inhibitor with a differentiated selectivity profile,” said Norbert Bischofberger, Ph.D., Forward-Looking Statements This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

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In-Vivo In-Vitro Bioavailability Clinical Trials 40

The Pharma Data

DECEMBER 3, 2020

Maribavir, an orally bioavailable anti-CMV compound, is the only antiviral agent presently in Phase 3 development for the treatment of post-transplant patients with CMV in SOT or HSCT. In transplant recipients, reactivation of CMV can lead to serious consequences including loss of the transplanted organ and, in extreme cases, can be fatal.

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Drugs Medicine Trials Development 52

The Pharma Data

NOVEMBER 17, 2020

The strong results from this Phase 1 readout reinforce our view that LYT-100 has the potential to offer a tolerability and bioavailability profile that could be highly differentiated at the same exposure levels as pirfenidone,” said Daphne Zohar, co-founder and chief executive officer of PureTech. Forward Looking Statement.

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Production Trials Bioavailability Drugs 52

Pharmaceutical Technology

NOVEMBER 24, 2022

Given our expertise in the provision of IVMT studies to investigate the absolute bioavailability of oral drug molecules, we have developed a particular focus in recent years on the conduct of integrated IVMT/ADME studies. What makes Quotient Sciences’ approach to these study types unique?

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The Pharma Data

NOVEMBER 26, 2020

Nanoform’s capabilities span the small to large molecule development space and the company focuses on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications. Certified Adviser: Danske Bank A/S, Finland Branch, +358 40 562 1806. For more information please visit [link].

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Containment Medicine Development Bioavailability 52

The Pharma Data

JANUARY 3, 2021

Nanoform’s capabilities span the small to large molecule development space and the company focuses on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications. Certified Adviser: Danske Bank A/S, Finland Branch, +358 40 562 1806. For more information please visit [link].

Containment 40

Containment Bioavailability Clinical Trials Clinical Trials 40

The Pharma Data

JANUARY 27, 2021

Each study is planned to be carried out over an approximately two-week period as an open label, randomized, crossover, two-period, two-sequence, single dose pilot study to assess the relative bioavailability of each product.

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Drugs Manufacturing Drug Delivery Production 52

FDA Law Blog

JANUARY 23, 2023

This subsection requires sponsors of any phase 3 or other pivotal drug study (other than bioavailability or bioequivalence studies) to submit diversity action plans by the time they submit the study protocol. Clinical Trial Diversity Under FDORA FDORA adds subsection 505(z) to the Food, Drug, and Cosmetic Act (FDC Act).

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Trials Clinical Trials Clinical Trials Drugs 59

The Pharma Data

MAY 16, 2021

Contains a unique “living chemistry” that was poorly understood until recently…. We’ll start with all-natural food #1 which contains powerful compounds that…. Because this food also contains a mineral that’s proven to help men over 45 burn fat, build muscle, and bound with energy…. Because the next ingredient contains….

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Production Containment Research Doctors 52

Pharmaceutical Technology

JUNE 14, 2023

This, coupled with small pharma companies being unable to acquire or access containment capabilities in-house, means that the demand for innovative specialized small molecule capabilities remains high. Premium specialized equipment is necessary because high containment facilities call for the separation of the operator from the product.

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Pharmaceutical Technology

APRIL 12, 2023

Containment and controlled substance capabilities are defining and necessary features for these manufacturing facilities, but not all contract manufacturers have the specialist equipment and capabilities required for high potency small molecule API production.

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Pharmaceutical Technology

MARCH 21, 2023

In 2022, the largest study of its kind in Latin America published clinical evidence [ii] on the effectiveness and safety of CBD oil-based cannabis formulations, containing reassuring data on the efficacy, safety, and cost-effectiveness of the products to treat chronic pain.

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Pharmaceutical Technology

FEBRUARY 3, 2023

Additionally, OSD manufacturing approaches are well developed, with processes that ensure a repeatable distribution of ingredients, uniformity in dissolution, and bioavailability, which verify that the drug product is safe and effective.

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Contamination Manufacturing Containment Production 130

Pharmaceutical Technology

MARCH 7, 2023

Safety issues must also be addressed, such as containment and potential ignition factors. Frewitt’s expertise also includes solutions to the API containment space, with both rigid and flexible isolators. The team required narrow nanoparticle size distribution with a short processing time and a stable low temperature milling profile.

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