XTalks
DECEMBER 4, 2024
Jotrol overcomes these barriers using patented micellar technology, enhancing bioavailability and enabling therapeutically effective doses. CAMP4’s RNA-based therapies focus on genetic diseases like urea cycle disorders, while Rapport’s small molecules aim to address epilepsy, pain and bipolar disorder.
XTalks
APRIL 11, 2023
Most people typically develop Parkinson’s disease after the age of 60, and early onset forms of Parkinson’s disease are often inherited, though some forms may be linked to genetic mutations or exposure to environmental toxins like pesticides. It is one of the fastest growing neurological diseases globally due to increasing aging populations.
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Roots Analysis
MAY 21, 2024
In fact, it has been observed that around 40% of the pharmaceutical drugs approved by regulatory organizations exhibit poor bioavailability / solubility. Further, every year, poor bioavailability is one of the main causes of drug failure in obtaining approval authorization.
Cloudbyz
MARCH 5, 2024
Oral Bioavailability: Developing small molecules that are effectively absorbed when administered orally, while also being stable in the digestive system, can be complex. Enhancing bioavailability is often a key focus in the development of small molecule drugs.
XTalks
SEPTEMBER 24, 2024
CDKL5 deficiency disorder (CDD) is a rare genetic condition caused by mutations in the CDKL5 gene, which is essential for brain development and function. They are exploring a prodrug formulation of ganaxolone to potentially enhance the patient experience and treatment effectiveness by aiming to improve the drug’s bioavailability.
Delveinsight
JANUARY 7, 2021
The prospects of small molecule binders of RNA over current protein and RNA-based approaches cover potency, selectivity, oral bioavailability, tissue distribution, and central nervous system penetration. Biotheranostics’ two PCR-based genetic tests are well established in the U.S.: Medical technology company Hologic Inc.
The Pharma Data
DECEMBER 9, 2020
Vigil’s pipeline strategy is to target these diseases by combining a high-level understanding of microglia physiology, disease genotyping, and patient phenotyping to identify specific genetic variations associated with microglial dysfunction.
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