Pharmaceutical Technology

NOVEMBER 24, 2022

The number of commercially available 14 C-labeled starting materials is limited, and unlike the medicinal chemistry or process chemistry routes, we are restricted to a few very simple building blocks. This has proved to be an extremely effective option for molecules where an understanding of absolute bioavailability is required.

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XTalks

AUGUST 8, 2024

Despite their potential, oligonucleotides present challenges in bioavailability due to their large, hydrophobic and negatively charged nature. Oligonucleotides such as antisense and small-interfering RNAs, are crafted using advanced chemical processes. They act by modifying protein expression, offering new treatments for rare diseases.

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Cloudbyz

MARCH 5, 2024

In the intricate dance of drug discovery and development, two protagonists emerge as the cornerstones of modern medicine: biologics and small molecules. Oral Bioavailability: Developing small molecules that are effectively absorbed when administered orally, while also being stable in the digestive system, can be complex.

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The Pharma Data

OCTOBER 15, 2020

a leading biotechnology company developing small molecule therapeutics based on its proprietary uSMITE platform of targeted protein degradation technology, today announced that the company’s internal program to develop selective degraders that target key proteins within the TRK family has been published by the Journal of Medicinal Chemistry.

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pharmaphorum

MAY 5, 2021

Pfizer expects revenues from its BioNTech-partnered COVID-19 vaccine to reach an eye-watering $26 billion this year, catapulting it to the top of the world’s biggest-selling medicines. . Feature image copyright BioNTech SE 2020, all rights reserved. The post Pfizer says COVID-19 jab could rake in $26bn this year appeared first on.

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Pharmaceutical Technology

AUGUST 3, 2022

Today, they are still thought to represent approximately two-thirds of all medicines administered through prescription and over-the-counter. The pharmaceutical industry is certainly no stranger to the unique challenges posed by their process development.

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Camargo

JULY 8, 2021

Researchers at the Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have observed that MAOIs might help the immune system attack cancer. Although still available as generics, for the most part they have been replaced by newer drugs with fewer side effects.

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Roots Analysis

JANUARY 28, 2024

Pharmaceutical Research: Big data analytics can be applied in various areas of pharmaceutical research, including drug discovery and development, precision medicine , clinical trial optimization, pharmacovigilance and drug safety, supply chain optimization, and real-time monitoring and surveillance.

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XTalks

FEBRUARY 3, 2023

Unlike fulvestrant, elacestrant is not only orally bioavailable, but it has also demonstrated longer steady-states and works as a better combination partner with inhibitor agents like CDK4/6. This approval follows the promising results of the Phase III EMERALD global clinical trial published in the Journal of Clinical Oncology.

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The Pharma Data

DECEMBER 29, 2020

Cybin is developing technologies and delivery systems, aiming to improve bioavailability, to potentially achieve the desired medicinal effects of psychedelics at low dosage levels. Cybin is a life sciences company advancing psychedelic pharmaceutical treatments for various psychiatric and neurological conditions.

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XTalks

APRIL 11, 2023

By avoiding the stomach entirely, there is increased bioavailability and more sustained relief from symptoms. Ambroxol is a cough medicine in the mucolytics family (thins and removes mucus from airways). ND0612 is currently in Phase III of clinical development and is supported by four years of safety data.

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Pharmaceutical Technology

FEBRUARY 13, 2023

Quotient Sciences was asked to select the best candidate based on material science and oral bioavailability considerations. Science-led candidate selection and candidate development The decision to select the right molecule at the end of the discovery phase is a critical milestone in advancing any new medicine.

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The Pharma Data

MARCH 8, 2021

Molnupiravir (EIDD-2801/MK-4482) is an investigational, orally-bioavailable form of a potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. About Molnupiravir.

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The Pharma Data

JANUARY 5, 2021

“The ability to specifically target the 3D structure of RNA opens up an array of new possibilities in medicine, and Ribometrix is building the capabilities to deliver on that promise,” said Michael Solomon, chief executive officer of Ribometrix.

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pharmaphorum

NOVEMBER 9, 2022

for the purpose of advancing disease-modifying oral medicines for debilitating chronic neurodegenerative disorders, by enabling investigational new drugs (IND) studies. A £16 million Series A financing – led by Omega Funds – has been announced by the innovative neuroscience company NRG Therapeutics Ltd.,

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XTalks

MAY 23, 2024

Innovations in Skin Cancer Treatment: Precision Medicine and Immunotherapy Treatment options for skin cancer have considerably evolved with a growing emphasis on precision medicine and immunotherapy. Precision medicine allows more effective and personalized treatment plans, which minimizes side effects and improves patient outcomes.

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Pharmaceutical Technology

JUNE 26, 2022

Understanding the polymorphism of a drug compound plays a key role in both drug substance and drug product development, because it can negatively impact the downstream stability, solubility, and bioavailability of a drug. Developing workable API solutions.

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The Pharma Data

NOVEMBER 26, 2020

This novel nanoparticle formation technology provides hope for improving the possibilities and probabilities of developing better medicines for patients and it expands Nanoform’s reach into the growing biological market. Nanoform is an innovative nanoparticle medicine enabling company. HELSINKI , Nov. Finnish time.

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The Pharma Data

OCTOBER 9, 2021

“The treatment of CMV in patients who have undergone a solid organ or stem cell transplant is complicated, especially in patients who have failed standard treatment and who may be at risk for side effects from currently available medications,” said Dr. Emily Blumberg, Director, Transplant Infectious Diseases, Penn Medicine.

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The Pharma Data

AUGUST 16, 2021

Lebrikizumab is a novel monoclonal antibody (mAb) that binds soluble IL-13 with high affinity, has high bioavailability, a long half-life and blocks IL-13 signaling. Fast Track designation is granted for a medicine that is intended to treat a serious condition and data demonstrate the potential to address an unmet medical need. .

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The Pharma Data

JANUARY 3, 2021

4, 2021 /PRNewswire/ — Nanoform Finland Plc (“Nanoform”), an innovative nanoparticle medicine enabling company, today announced a new near-term business target. Nanoform is an innovative nanoparticle medicine enabling company. HELSINKI , Jan. Finnish time. About Nanoform.

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Delveinsight

FEBRUARY 16, 2021

The data was presented at the virtual 2021 Genitourinary Cancers Symposium (ASCO GU) and also published in the New England Journal of Medicine. Maribavir is an orally bioavailable anti-CMV compound. The combo treatment also met key secondary endpoints of overall survival (OS) and objective response rate (ORR).

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The Pharma Data

NOVEMBER 22, 2020

Founded in 2007, Alzprotect is a French Lille-based company created by Dr. André Delacourte, one of the pioneers of research on Alzheimer’s disease, and Dr. Patricia Melnyk, expert in medicinal chemistry, in collaboration with University of Lille and Inserm. About XERYS.

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Roots Analysis

OCTOBER 2, 2023

Additionally, it increases the bioavailability and solubility of the attached molecule. In fact, in the last twenty years, the United States Food and Drug Administration (USFDA) and the European Medicines Agency (EMA) have authorized the market approval of around 80 nanomedicines.

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Roots Analysis

SEPTEMBER 1, 2023

By using real-world evidence , researchers can gain clinically useful insights that can help improve the quality of care delivery in precision medicine. As the field continues to advance, it is expected to have a profound impact on the future of medicine.

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The Pharma Data

DECEMBER 9, 2020

Li is a prominent neuroscientist and former professor at Johns Hopkins Medicine. Artificial intelligence holds immense promise to catalyze the development of the next generation of highly selective, orally bioavailable molecules, with reduced side effects, for the most impactful drug targets,” Feinberg said at the time of the launch.

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The Pharma Data

APRIL 11, 2023

Bioequivalence and relative bioavailability were established between the once-daily and twice-daily tablet formulations, with no new safety findings emerging. NYSE and TASE: TEVA) has been developing and producing medicines to improve people’s lives for more than a century. Source link: [link]

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The Pharma Data

DECEMBER 8, 2020

Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced the pricing of an underwritten public offering of 8,110,000 shares of its common stock at a price to the public of $37.00 SAN DIEGO, Dec. About Kura Oncology.

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The Pharma Data

DECEMBER 3, 2020

Food and Drug Administration and European Medicines Agency as we work to bring maribavir to patients.”. Maribavir, an orally bioavailable anti-CMV compound, is the only antiviral agent presently in Phase 3 development for the treatment of post-transplant patients with CMV in SOT or HSCT. About Maribavir.

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The Pharma Data

MAY 14, 2021

And the unique Japanese mushroom trio – Maitake, Reishi and Shiitake- which were proven to have incredible health properties by one study in the Journal of Oxidative Medicine and Cellular Longevity! We also added Cat’s Claw and Tomato Fruit Powder to further help and support the good functioning of your prostate.

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The Pharma Data

DECEMBER 1, 2020

–( BUSINESS WIRE )– Genesis Therapeutics , a company pioneering AI technologies to create medicines for patients with severe and unmet medical needs, has completed its $52M Series A financing round. 2, 2020 11:00 UTC. BURLINGAME, Calif.–( Rock Springs Capital led the round. Feinberg, Ph.D., Genesis’ CEO and co-founder. “We

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The Pharma Data

NOVEMBER 19, 2020

These compounds have demonstrated high potency in inhibiting the activity of the M pro protease as well as promising oral bioavailability and blood plasma levels in animal studies. Several compounds are being further optimized for preclinical studies. Details can be found at this link.

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The Pharma Data

MARCH 11, 2021

Last May, Lilly’s first-in-class oral precision medicine, Retevmo received Accelerated Approval from the U.S. Presentation Title: Preclinical characterization of LY3484356, a novel, potent and orally bioavailable selective estrogen receptor degrader (SERD). Portfolio Highlights. Abstract Number: 1236. Retevmo is an U.S.

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Delveinsight

JULY 30, 2020

A novel, brain penetrant, orally bioavailable and selective PPAR? Magenta Therapeutics , a clinical-stage biotechnology company is evaluating its one-time cell therapy, MGTA-456 for the treatment of multiple inherited metabolic disorders, which has received Regenerative Medicine Advance Therapy (RMAT) designation from the US FDA.

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XTalks

AUGUST 30, 2022

We know that a lot of different pathologies, especially as we’ve entered the era of molecular medicine and gene therapies, cause many of the same symptoms and work through final common pathways. Targeting the CNS directly has been successful in modern medicine. Next Steps for Targeted CNS Delivery. The patients are waiting!

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The Pharma Data

JANUARY 27, 2021

Further to XPhyto’s press release dated January 18, 2021, the Company’s core milestones for this year include the commercialization of infectious disease diagnostics, the clinical validation of transdermal and sublingual drug formulations and continued investment in psychedelic medicine. About XPhyto Therapeutics Corp.

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The Pharma Data

NOVEMBER 17, 2020

The strong results from this Phase 1 readout reinforce our view that LYT-100 has the potential to offer a tolerability and bioavailability profile that could be highly differentiated at the same exposure levels as pirfenidone,” said Daphne Zohar, co-founder and chief executive officer of PureTech. About PureTech Health.

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