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Alnylam Pharmaceuticals and collaborators have identified rare mutations in the INHBE gene that is expressed in the liver, related to a lower waist-to-hip ratio for body mass index (BMI), which is often used as an indicator of abdominal fat and is correlated with the risk of type 2 diabetes (T2D) and coronary heart disease.
The AI approach helps model a disease using a map of successive changes in geneexpression at the onset and during the progression of the disease. The underlying algorithms ensure that the identified geneexpression patterns are ‘invariant’ regardless of different disease cohorts.
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