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UK agency pilots biobank to study links between genetics and drug side effects

Pharmaceutical Technology

The Medicines and Healthcare products Regulatory Agency (MHRA) aims to launch a pilot genetic biobank that will gather patient data to associate drug-related adverse events to their genetic makeup. The Yellow Card biobank will launch as a joint venture with the UK-government funded entity Genomics England on June 1.

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Poor sleep may bolster genetic susceptibility to asthma, potentially doubling risk

Medical Xpress

Poor quality sleep may bolster a person's genetic susceptibility to asthma, potentially doubling their risk of being diagnosed with the condition, suggests a large UK Biobank study, published in BMJ Open Respiratory Research.

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Ten new genetic loci linked to osteoarthritis found

Medical Xpress

A team of researchers affiliated with several institutions in Alabama has linked 10 genetic loci to the development of osteoarthritis. In their paper published in the journal Nature Genetics, the group describes their analysis of data from the Million Veteran Program in the U.S. and the UK Biobank in the U.K.

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Can genetic data be a magic bullet for drug R&D?

pharmaphorum

Ben Hargreaves finds that the vast amount of genetic data that exists today could help provide a faster, more targeted way of developing new drug candidates. The logical extension to this kind of approach is treating individual patients, with their individual genetic makeup.

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Biorepositories as a Guiding Resource for Research & Drug Discovery

XTalks

Generation of strong research dataset cohorts must begin with high-quality clinical samples. Biobanks are used for the coordination of high-yield patient sample collection. The webinar highlighted the importance of maximizing utility and sustainability for the long-term success of biorepositories and biobanks.

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Alnylam finds belly fat gene and drug target in UK Biobank study

pharmaphorum

The RNA interference specialist says its researchers and collaborators have identified mutations in a gene called INHBE that are associated with protection against abdominal obesity and metabolic syndrome – a condition impacting more than 20% of adults worldwide. . Image by Bruno /Germany from Pixabay .

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Large-scale study enables new insights into rare eye disorders

Medical Xpress

Researchers have analyzed image and genomic data from the UK Biobank to find insights into rare diseases of the human eye. These include retinal dystrophies—a group of inherited disorders affecting the retina—which are also the leading cause of blindness certification in working-age adults.