Rethinking Clinical Trials

APRIL 26, 2023

Semler is an assistant professor of medicine and bioinformatics and the medical director of the Center for Learning Healthcare in the Vanderbilt Center for Clinical and Translational Research. Join the online meeting.

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pharmaphorum

MAY 27, 2022

This is the second in a two-part series examining how pharma can embrace the DEI agenda to create more effective medicines through more representative clinical trials. The same principles are increasingly being applied to clinical trials to improve diversity, mitigate bias, and reinforce inclusion in clinical trials.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post What Is the Intraclass Correlation Coefficient? appeared first on Rethinking Clinical Trials. Liz Turner discusses the intraclass correlation coefficient.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post What Are the Types of CRT Designs? appeared first on Rethinking Clinical Trials. Liz Turner discusses the types of CRT designs.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post How Does Clustering Affect Power and Detectable Difference? appeared first on Rethinking Clinical Trials.

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Pharmaceutical Technology

FEBRUARY 17, 2023

Oncology-focused bioinformatics firm M2GEN has entered a multi-year strategic collaboration with Zephyr AI to identify treatments and cures for cancer patients. M2GEN and Zephyr AI will together discover new cancer treatments and expanded use cases for better identifying new targets and enhancing clinical trial design.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post What Are the Reasons to Randomize Clusters Instead of Individuals? appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Liz Turner discusses outcome clustering and how it can affect a trial. Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post What Is Outcome Clustering, and How Can It Affect a Trial? appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post How Do You Estimate the Degree of Clustering for Outcomes? appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post What Are the Arguments For and Against the Stepped-Wedge Design? appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

OCTOBER 17, 2023

Speaker Liz Turner, PhD Associate Professor, Biostatistics and Bioinformatics and Global Health Biostatistics and Study Design Core Co-Chair The post What Is An Example of How to Choose a Study Design? appeared first on Rethinking Clinical Trials. Liz Turner discusses an example of how to choose a study design.

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XTalks

NOVEMBER 7, 2022

Gleich, MD, FACS, Senior Vice President, Medical Department, and Dr. Christopher Huth, PhD, Senior Clinical Trial Manager, Clinical Trial Management. Liquid Biopsy Use in Oncology Clinical Trials. Optimal methods for bioinformatic analysis are still needed. percent show less reliability).

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BioTech 365

NOVEMBER 29, 2021

Global Biomarkers Markets, Technology & Competitive Landscape Report 2020-2021 & 2030: Focus on Proteomics, Metabolomics, Molecular Diagnostics, Drug Discovery, Clinical Trials, and Bioinformatics – ResearchAndMarkets.com Global Biomarkers Markets, Technology & Competitive Landscape Report 2020-2021 & 2030: Focus on Proteomics, (..)

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pharmaphorum

SEPTEMBER 16, 2022

It also bodes well for improving clinical trial success rates. The overarching desire to reduce in some way the “translational valley of death” of failed clinical trials is palpable. A notable issue with clinical trials is the homogeneity of the patient database. But mere volition does not enact results.

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pharmaphorum

APRIL 1, 2021

They go into bioinformatics”. There’s a lot of bioinformatics know-how and talent and a lot of good scientists who would like to better understand biology but don’t have the money to do it in wet settings. They go into bioinformatics.”. So what do they do? So, what do they do?

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Scienmag

MAY 19, 2021

Proprietary bioinformatics, paired with comprehensive clinical curation results in reporting that defines clinically actionable, FDA-approved, and clinical trial drug options for the management of the patient’s cancer.

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XTalks

APRIL 21, 2023

Biotech company Ultima Genomics has joined forces with Genome Insight, a bioinformatics-based biomedicine company, to overcome the caveat of cost and quality in WGS. Ultima Genomics will provide their high-throughput NGS instrument platform, the UG 100, and Genome Insight will provide the bioinformatics platform for data analysis.

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pharmaphorum

SEPTEMBER 14, 2020

Genomics also means we will be able to stratify patients, based upon their genomic makeup, to make clinical trials much more efficient and targeted. While the clinical trial was successful in stopping seizures in around 72% of patients, which is an amazing result, nearly one third of patients did not respond.

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XTalks

SEPTEMBER 5, 2023

Investigation of the possibility of VAED is crucial during clinical trials for decision-making on vaccine licensing by regulatory agencies. In the majority of cases, the risk of VAED is brought to light during preclinical stages or early clinical trial phases.

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pharmaphorum

JANUARY 11, 2023

The prevailing trend – that looks set to continue into 2023 and beyond – is the direction of a smaller pot of money towards digital health ventures that can offer “clinical strength”; in other words, those that can demonstrate an evidence-based approach drawing on clinical trials, regulatory filings, and/or peer-reviewed publications.

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Scienmag

DECEMBER 10, 2020

Clinical trial at Moores Cancer Center at UC San Diego Health individualizes TIL therapy for patients with melanoma or head and neck cancers Credit: UC San Diego Health Sciences Since 2016, Bernard Thurman has undergone traditional treatments, experimental therapies and surgeries to counter the cancer within him, but nothing has successfully eradicated (..)

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pharmaphorum

OCTOBER 20, 2021

The system could also have applications in evaluating drugs in clinical trials, helping to gauge if a therapy is having an impact early on in the disease process.

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XTalks

SEPTEMBER 28, 2020

The test is based on the detection of actionable genes – genes with known driver mutations that can be targeted by an approved therapy (or investigational therapies in clinical trials). The panel of genes in the test only include known NSCLC-associated genes, making the test specific to the disease.

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STAT News

MARCH 6, 2023

Unlike most people who receive medications yet to be cleared by the Food and Drug Administration, none of these patients is getting the vaccines as part of a clinical trial. Thirteen patients are waiting for their vaccine to be made. Typically, those patients pay nothing, in contrast to the foundation initiative.

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XTalks

MAY 20, 2022

A Clinical Scientist will perform a wide range of duties depending on the focus of their research. Here is a summary of the kind of work you can expect to do: Design and implement clinical trials for human diseases and treatment. What Field Can You Work in as a Clinical Scientist? Liaise with stakeholders and scientists.

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Scienmag

JUNE 22, 2021

Credit: Insilco June 22, 2021, New York / Hong Kong — Insilico Medicine, a global leader in end-to-end artificial intelligence for target discovery, small molecule chemistry, and clinical development, announced that it has closed a $255 million from biotechnology experts to progress Insilico Medicine’s current therapeutic programs into (..)

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Scienmag

NOVEMBER 9, 2020

Credit: Insilico Tuesday, November 10, 2020 (9AM Beijing) – Insilico Medicine, a leader in deep generative reinforcement learning for target discovery, small molecule generation, and prediction of clinical trial outcomes, today announced that it entered into a multi-target drug discovery agreement with Janssen Pharmaceutica N.V.

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pharmaphorum

MARCH 28, 2022

AION Labs’ third call for applications seeks computational biologists, bioinformatics and cheminformatics scientists, AI researchers, and antibody or protein engineers at academic and industry research labs worldwide to assemble a fully funded start-up company.

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pharmaphorum

APRIL 15, 2021

“When the pandemic struck, we pivoted basically overnight to integrate many remote and digital processes – things like preparing submission dossiers remotely, but also decentralised clinical trials which are more patient-centric as the trial revolves around the patient and not the test center.

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The Pharma Data

JULY 27, 2021

is a clinical stage biotechnology company developing a new class of biologics, Human Heavy-Chain Antibodies (UniAb®), for the treatments of cancer, autoimmunity, and infectious diseases. Even when clinical trials are successful, regulatory authorities may question the sufficiency for approval of the trial endpoints we have selected.

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Scienmag

JUNE 22, 2021

CTCELLS Co., selected for ‘200 Baby Unicorns’ organized by MSS & KISED Credit: DGIST CTCELLS, established by Prof.

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The Pharma Data

DECEMBER 8, 2020

Under the Orphan Drug Act, FDA may provide grant funding toward clinical trial costs, tax advantages, FDA user-fee benefits, and seven years of market exclusivity in the United States following marketing approval by FDA.

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Scienmag

JUNE 17, 2021

AURORA, COLORADO, June 16, 2021 — Foresight Diagnostics, the emerging leader in blood-based lymphoma disease monitoring, announced today that clinical performance of its minimal residual disease (MRD) detection platform in diffuse large B-cell lymphoma (DLBCL) will be presented at the 16th International Conference on Malignant Lymphoma (ICML) (..)

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The Pharma Data

JANUARY 10, 2021

I actually think neuroscience is going to heat up in 2021,” said Ben Zeskind , co-founder and CEO of Immuneering , which is using bioinformatics and computational biology to develop new drugs in this space, along with oncology and immuno-oncology. Moving on From the Amyloid Hypothesis. “I That is, faster approval of drugs in general.

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The Pharma Data

OCTOBER 27, 2020

The growth in Orenitram revenues resulted primarily from an increase in quantities sold, as the number of patients being treated with Orenitram grew following the update to Orenitram’s labeling to reflect the FREEDOM-EV clinical trial results, partially offset by the impact of the Excess Order.

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The Pharma Data

SEPTEMBER 1, 2020

.–( BUSINESS WIRE )– Bristol Myers Squibb (NYSE:BMY) today announced interim results from the Phase 3 open-label extension trial DAYBREAK, demonstrating the long-term efficacy and safety profile of Zeposia (ozanimod) in patients with relapsing forms of multiple sclerosis (MS). Presentation Topic: Clinical Trials.

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Rethinking Clinical Trials

OCTOBER 15, 2024

A new case study from the NIH Pragmatic Trials Collaboratory highlights an interim reassessment of sample size during an ongoing cluster randomized trial. The case study was published this week in the Living Textbook of Pragmatic Clinical Trials.

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