Scienmag

JANUARY 29, 2021

In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the “wake-sleep” cycle.

Gene 69

Gene Scientist Medicine Research 69

Drug Discovery World

APRIL 18, 2023

Among individuals who consented to whole-exome sequencing and were identified as carriers of predisposition genes for hereditary breast and ovarian cancer (HBOC) or Lynch syndrome, 39.2% would not have qualified for genetic screening under current guidelines, according to results from the Tapestry clinical trial presented at AACR 2023 today.

Genetics 52

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Scienmag

OCTOBER 5, 2020

Road trips result in the first shattering gene found in a wild population ST. LOUIS, MO — For years, Elizabeth (Toby) Kellogg, PhD, member and Robert E.

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Scienmag

JANUARY 13, 2021

International Ukraine Genetic Diversity Project finds a quarter of the genetic variation in Europe, dramatically increasing information on population diversity and medical genetic variation Credit: Oakland University Today, the largest study of genetic diversity in Ukraine was published in the open science journal GigaScience.

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Scienmag

NOVEMBER 12, 2020

In a study that has unprecedented implications to advance both medicine and biodiversity conservation, researchers have sequenced 131 new placental mammal genomes, bringing the worldwide total to more than 250 In a study that has unprecedented implications to advance both medicine and biodiversity conservation, researchers have sequenced 131 new placental (..)

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Scienmag

DECEMBER 16, 2020

15, 2020 — The Translational Genomics Research Institute (TGen), an affiliate of City of Hope, has identified a specific genetic target that could help explain the tremendous variation in how sick those infected with COVID-19 become. Comparative analysis of human and animal coronaviruses strains implicates miR1307 PHOENIX, Ariz.

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Scienmag

APRIL 27, 2021

Credit: Nigel Michki Neurons result from a highly complex and unique series of cell divisions. For example, in fruit flies, the process starts with stem cells that divide into mother cells (progenitor cells), that then divide into precursor cells that eventually become neurons.

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XTalks

SEPTEMBER 28, 2020

The test is based on the detection of actionable genes – genes with known driver mutations that can be targeted by an approved therapy (or investigational therapies in clinical trials). The panel of genes in the test only include known NSCLC-associated genes, making the test specific to the disease. Personalized Approach.

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Scienmag

APRIL 8, 2021

Credit: IRB Barcelona In cancer, personalised medicine takes advantage of the unique genetic changes in an individual tumour to find its vulnerabilities and fight it. Many tumours have a higher number of mutations due to a antiviral defence mechanism, the APOBEC system, which can accidentally damage DNA and cause mutations.

Scientist 53

Scientist DNA Genetics Medicine 53

Drug Discovery World

APRIL 14, 2023

Carl H June, MD, FAACR – Lifetime Achievement in Cancer Research June, a Fellow of the AACR Academy, is the Richard W Vague Professor in Immunotherapy, Director of the Center for Cellular Immunotherapies, and Director of the Parker Institute for Cancer Immunotherapy in the Perelman School of Medicine at the University of Pennsylvania.

Genetics 52

Genetics Research Medicine Clinical Research 52

Drug Discovery World

JULY 26, 2023

An industry overview of the role of the microbiome in precision medicine, and its interplay with research tools, diagnostics, and therapeutic development. But what advancements are taking place within microbiome-based precision medicine and how is it being used within oncology?

Medicine 52

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Scienmag

JULY 16, 2021

Credit: Vaughn Cooper PITTSBURGH, July 16, 2021 – For the first time ever, researchers from the University of Pittsburgh School of Medicine discovered that phages–tiny viruses that attack bacteria–are key to initiating rapid bacterial evolution leading to the emergence of treatment-resistant “superbugs.”

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pharmaphorum

SEPTEMBER 14, 2020

Last week geneticist Dr Charles Steward shared with us his experiences of searching for a genetic cause for his children’s rare neurological diseases. Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential.

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Genome Genomics Medicine Gene 107

Drug Discovery World

OCTOBER 25, 2023

DG : I think the most impact is being made in personalised medicine. There are two main concepts underlying this impact; we’ve known for a few years now that people can have variable responses to the same medication and that these responses are largely based on an individual’s genetic makeup. The second concept is largely in oncology.

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XTalks

DECEMBER 13, 2023

These efforts encompass programs related to the shingles vaccine, Tdap vaccine and plague vaccine, reinforcing Dynavax’s commitment to advancing the field of vaccines and medicine. The year 2022 has proven to be a momentous period for Fulgent Genetics, marked by significant expansion of its product portfolio across various medical conditions.

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Genetics Vaccination Vaccine DNA 111

Drug Discovery World

JULY 11, 2023

Advances in imaging technology, high-quality DNA and mRNA sequencing, and large-scale proteomics have yielded a plethora of data that can be analysed and cross- referenced to identify disease target genes or biological response signatures.

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Big Data Development Life Science Drugs 40

Scienmag

MARCH 22, 2021

Credit: WEHI, Australia Melbourne researchers have revealed how melanoma cells are flooded with DNA changes as this skin cancer progresses from early, treatable stages through to fatal end-stage disease.

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DNA Genome Genomics Research 96

Drug Discovery World

FEBRUARY 6, 2023

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care.

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Big Data RNA Bioinformatics Vaccination 52

Scienmag

AUGUST 21, 2020

Credit: Matt Verdolivo/UC Davis Humans are not the only species facing a potential threat from SARS-CoV-2, the novel coronavirus that causes COVID-19, according to a new study from the University of California, Davis.

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XTalks

NOVEMBER 7, 2022

Such information can reveal details about tumor staging, tumor progression, heterogeneity, gene mutations and clonal evolution. Dr. Bahassi explained that technological advances in genetic sequencing of cfDNA have enabled liquid biopsies and led to marked increase in the detection of therapeutically-targetable mutations.

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Scienmag

MARCH 1, 2021

Screening for predictive factors of drug resistance and tailored therapies can improve outcomes in patients with refractory diffuse large B-cell lymphoma White blood cells or lymphocytes are the soldiers of our immune system that patrol the body via the lymphatic system.

Drugs 75

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Scienmag

SEPTEMBER 30, 2020

Researchers engineer RNA-targeting compounds that disable the pandemic coronavirus’ replication engine Credit: Scott Wiseman for Scripps Research JUPITER, FL – Sept.

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Scienmag

SEPTEMBER 4, 2020

ERC Starting Grants for Professor Dr Martina Hofmanová and Dr Toni Goßmann Credit: Photo: Bielefeld University /S. Jonek The European Research Council (ERC) has awarded ERC Starting Grants to two researchers from Bielefeld University. They will each receive 1.5 million euros for top-level research in their disciplines.

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Scienmag

APRIL 20, 2021

A new study challenges the presumption that all South-Eastern-Bantu speaking groups are a single genetic entity. Almost 80% of South Africans speak one of the SEB family languages as their first language.

Genetics 61

Genetics Research Bioinformatics Gene 61

Drug Discovery World

APRIL 21, 2023

Managing all of these elements using iterative design and prototyping can play a key role in successful project delivery, and marrying technologies with biochemical or cellular assays has the potential to bring disruptive change across fields as diverse as personalised medicine, diagnostics and drug screening.

Doctors 52

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Drug Discovery World

NOVEMBER 15, 2022

If you want to order gene-length sequences, rather than short oligos for PCR, the waiting times are around two or three weeks at least. Modern advances in DNA synthesis, however, have made it possible to leverage gene-to- antibody production platforms where input candidate DNA sequences can be turned into purified antibodies.

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Drug Discovery World

NOVEMBER 9, 2023

James Cooke, PhD, Associate Director, Bicycle Therapeutics, on: ‘Engineering bicyclic peptides for precision targeted medicine’. Marine Houdou, Genetic Engineering Specialist, Polyplus, on: ‘From modular DNA assembly to recombinant protein production at Polyplus’. The session ends with two presentations and two luncheon presentations.

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The Pharma Data

JANUARY 10, 2021

I actually think neuroscience is going to heat up in 2021,” said Ben Zeskind , co-founder and CEO of Immuneering , which is using bioinformatics and computational biology to develop new drugs in this space, along with oncology and immuno-oncology. Really, a lot of the drugs that we use in clinical practice are actually preventative medicines.

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Vaccination Vaccine Regulation Drugs 52

Scienmag

NOVEMBER 11, 2020

New method bridges in situ microscopy with single cell omics Credit: Wheeler lab Scientists can now select individual cells from a population that grows on the surface of a laboratory dish and study their molecular contents. Developed by University of Toronto researchers, the new tool will enable a deeper study of stem cells and other […].

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