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NSF backs bioinformatics approach to understanding plant RNA modifications

Scienmag

Led by Boyce Thompson Institute’s Andrew Nelson, four partners will identify RNA modifications and develop resources that may lead to hardier crops Credit: Photo credit: Anna Nelson Dittrich ITHACA, NY, August 4, 2020 — RNA perform a variety of functions in cells, helping with everything from regulating genes to building proteins.

RNA 74
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A human interactome to prioritize drug discovery

Medical Xpress

Scientists at Open Targets, EMBL's European Bioinformatics Institute (EMBL-EBI), and GSK are revealing the shared basis of diseases using a map of interacting human proteins.

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Astellas teams up with UK biotech Mogrify on hearing loss project

pharmaphorum

It can be caused by exposure to loud noises – including prolonged use of earbuds at high volumes – as well as cancer treatment, illnesses, genetic mutations, or aging. An estimated 1.57

In-Vivo 110
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Sensyne, Oxford University deploy AI to find asthma targets

pharmaphorum

The partners will also examine the transcriptomes of around 60 participants – in other words the messenger RNA coded for by genes that in turn is used to produce proteins – and carry out bioinformatic analyses to tease out new pathways involved in asthma.

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The future of AI drug discovery & development in immunology and GPCR research

pharmaphorum

A mere six months ago Verily launched the study with Sosei Heptares – a global leader in GPCR structure-based drug design – with an aim to “prioritise protein targets for therapeutic targeting in immune-mediated disease”. What, then, is the solution? It also bodes well for improving clinical trial success rates. About the interviewee.

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Likely molecular mechanisms of SARS-CoV-2 pathogenesis are revealed by network biology

Scienmag

– Viral and bacterial pathogens wield pathogenic or virulent proteins that interact with high-value targets inside human cells, attacking what is known as the host interactome. The host interactome is the network map of all the protein-protein […]. Credit: UAB BIRMINGHAM, Ala.

Protein 85
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The future of genomic medicine: can it fulfil its promises?

pharmaphorum

Last week geneticist Dr Charles Steward shared with us his experiences of searching for a genetic cause for his children’s rare neurological diseases. While there may be just under 20,000 confirmed protein coding genes, it turns out that much of the genome outside of these genes is also important in regulating how the genome is controlled.

Genomics 119