Scienmag

AUGUST 20, 2020

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can […]. (..)

Genetics 41

Genetics Gene Genomics Genome 41

Scienmag

FEBRUARY 24, 2021

According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. Credit: UEF/Raija Törrönen.

Gene 52

Gene Genetics Regulation Cardiology 52

Scienmag

MAY 5, 2021

Study published in JAMA Cardiology Credit: UIC/Jenny Fontaine A new mutation found in a gene associated with an increased risk of atrial fibrillation poses a significantly increased risk for heart failure in Black people.

Cardiology 53

Cardiology Genetics Gene Research 53

Medical Xpress

FEBRUARY 6, 2023

A genetic score may be able to identify higher stroke risk—but only for people living in the most privileged neighborhoods, according to new research that highlights inequities related to wealth and health.

Gene 75

Gene Genetics Research Cardiology 75

Scienmag

MARCH 31, 2021

Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure Credit: In-Hyuk Jung, PhD, Stitziel Lab High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke.

Scientist 62

Scientist Genetics Gene Medicine 62

Scienmag

APRIL 28, 2021

In a world first study of 390,435 people, University of South Australia researchers found causal genetic evidence that cardio health […].

Genetics 52

Genetics Research Gene Cardiology 52

XTalks

APRIL 15, 2021

Dr. Benoit Tyl, MD, FESC, medical and scientific director, cardiology at Servier, says that the disconnect between correlation and causality in cardiovascular disease trials is partially responsible for the lack of approved HFpEF therapies. Figure 1: The use of Mendelian randomization to validate genetic drug targets.

Development 98

Development Drugs Genomics Genome 98

Scienmag

DECEMBER 3, 2020

Using a new variant to repair DNA will improve both safety and effectiveness of the much-touted CRISPR-Cas9 tool in genetic research, Michigan Medicine researchers say. Eugene Chen, M.D., […].

Gene Editing 41

Gene Editing Gene DNA Genetics 41

STAT News

JULY 12, 2022

Somewhere in New Zealand, the first patient ever has been dosed with a kind of gene-editing treatment known as a base editor, a newer way of utilizing CRISPR for gene editing. The company studying the treatment, Verve Therapeutics, announced the news Tuesday. Continue to STAT+ to read the full story…

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Gene Editing Gene Therapy Gene Cardiology 98

Scienmag

NOVEMBER 9, 2020

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina. Credit: Medical University of South Carolina According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies.

Gene 52

Gene Gene Expression Research Cardiology 52

Scienmag

MAY 18, 2021

Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome. In recent years, the mix of these resident bacteria, and the […].

Bacteria 74

Bacteria Genetics Scientist Gene 74

XTalks

SEPTEMBER 4, 2024

The data, presented at the European Society of Cardiology Congress 2024, suggest that vutrisiran could significantly reduce the risk of death and heart-related issues, marking a potential treatment breakthrough. Vutrisiran works by silencing the gene responsible for producing TTR, reducing both mutant and wild-type TTR proteins.

Trials 52

Trials RNA Protein Gene Editing 52

Scienmag

SEPTEMBER 24, 2020

New light is being shed on a little-known role of Y chromosome genes, specific to males, that could explain why men suffer differently than women from various diseases, including Covid-19.

Gene 60

Gene Research Cardiology Genetics 60

pharmaphorum

AUGUST 13, 2020

Adding in Regeneron’s antibody resulted in a 49% drop in cholesterol levels from the start of the study compared to patients sticking with their current therapy alone, according to results presented earlier this year at the American College of Cardiology’ congress in March.

Drugs 52

Drugs Antibody Sales Cardiology 52

Scienmag

OCTOBER 15, 2020

Benoit Bruneau and Katie Pollard study DNA folding to identify the genetic causes of congenital heart disease Credit: Photo: Gladstone Institutes SAN FRANCISCO, CA–October 15, 2020–The National Institutes of Health (NIH) has granted a 4D Nucleome award to support research by a group of scientists at Gladstone Institutes led by Benoit Bruneau, (..)

DNA 54

DNA Genetics Scientist Research 54

Scienmag

MAY 17, 2021

Patients’ genetic profile strongly influences size of effect in early-phase trial People with extremely high levels of triglycerides (a type of fat in the blood) and a specific genetic profile saw a substantial reduction in triglycerides after taking the human monoclonal antibody evinacumab compared with those taking a placebo, in a study presented (..)

Genetics 42

Genetics Antibody Trials Gene Therapy 42

Scienmag

NOVEMBER 19, 2020

Precise treatment leads to resolution of patient’s debilitating symptoms and complete remodeling of her lymphatic system Philadelphia, November 20, 2020–Researchers at Children’s Hospital of Philadelphia (CHOP) have resolved a severe lymphatic disorder in a girl with Noonan Syndrome that had led to upper gastrointestinal bleeding, (..)

Research 67

Research Gene Cardiology Genetics 67

The Pharma Data

SEPTEMBER 15, 2020

Pfizer’s Rare Disease late-stage pipeline currently includes three gene therapy programs that, if successful, are expected to gain regulatory approval by the end of 2023, with an additional pipeline of 10 preclinical initiatives that are at various stages of maturity. and -50.4%

Gene Therapy 52

Gene Therapy Vaccination Vaccine Trials 52

Scienmag

SEPTEMBER 8, 2020

Salk study is the first to reveal ways cells from the human circulatory system change with age and age-related diseases Credit: Bersini, Schulte et al.

Scientist 54

Scientist Gerontology Gene Cardiology 54

Scienmag

OCTOBER 22, 2020

Scientists cannot be expected to drop everything they’re working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe.

Research 41

Research Scientist Medicine Gene 41

Scienmag

SEPTEMBER 6, 2020

SCAD is poorly understood, and it’s so far impossible to predict which combination of genes and environmental triggers will lead […].

Genetics 46

Genetics Gene Cardiology Medicine 46

The Pharma Data

OCTOBER 27, 2021

Appointment further strengthens Board scientific capabilities, including in genetics which is central to GSK’s R&D approach. Dietz MD, Professor of Genetic Medicine at The Johns Hopkins University School of Medicine in the United States, will join the Board of the Company as a Non-Executive Director. Dr Hal Dietz is Victor A.

Genetics 52

Genetics Medicine Cardiology Scientist 52

The Pharma Data

MAY 13, 2021

Journal of the American College of Cardiology. Neural and Genetic Correlates of the Social Sharing of Happiness. Opiate-like effects of sugar on gene expression in reward areas of the rat brain. DOI: 10.1111/adb.12134. Malik VS, Hu FB. 2015;66(14):1615-1624. DOI: 10.1016/j.jacc.2015.08.025. 2015.08.025. . Hashimoto K, ed.

Insulin 52

Insulin Production Hormones Medicine 52