Scienmag

APRIL 30, 2022

Budapest, Hungary – 30 April 2022: A method for delivering genetic material to the body is being tested as a way to repair damaged heart muscle after a heart attack. The ground-breaking research is presented today at Frontiers in CardioVascular Biomedicine 2022, a scientific congress of the European Society of Cardiology (ESC).1

Cardiology 82

Cardiology Vaccination Vaccine Genetics 82

Scienmag

JULY 13, 2021

Circulation: Genomic and Precision Medicine Journal Report DALLAS, July 13, 2021 — Sharing the results of genetic testing for cardiomyopathy in adolescents ages 13-18 does not appear to cause emotional harm to families or adversely impact family function or dynamics, according to new research published today in Circulation: Genomic and Precision (..)

Genetics 75

Genetics Genomics Genome Medicine 75

Pharmaceutical Technology

SEPTEMBER 21, 2022

Renovacor focuses on offering precision treatments for genetic cardiovascular and mechanistically-related ailments. Building on our success in Danon Disease to date, I am particularly excited to expand our cardiology focus and capabilities and address a clear unmet medical need in BAG3-associated dilated cardiomyopathy. “By

Gene Therapy 147

Gene Therapy Gene Cardiology Genetics 147

Medical Xpress

MAY 1, 2023

To get an inside look at the heart, cardiologists often use electrocardiograms (ECGs) to trace its electrical activity and magnetic resonance images (MRIs) to map its structure. Because the two types of data reveal different details about the heart, physicians typically study them separately to diagnose heart conditions.

Genetics 98

Genetics Cardiology 98

Medical Xpress

NOVEMBER 14, 2022

Ten months after transplanting the first genetically-modified pig heart into a human patient, University of Maryland School of Medicine (UMSOM) researchers continue to report on new findings from the landmark transplant.

Genetics 70

Genetics Medicine Research Cardiology 70

Scienmag

JUNE 16, 2022

Sophia Antipolis, 17 June 2022: Recommendations on how to use gene testing to prevent sudden cardiac death in athletes and enable safe exercise are published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1

Cardiology 58

Cardiology Genetics Gene 58

STAT News

AUGUST 4, 2022

When coronary arteries are blocked, starving the heart of blood, there are good medications and treatments to deploy, from statins to stents. Not so for heart failure, the leading factor involved in heart disease, the top cause of death worldwide. “It’s what’s on death certificates,” said cardiologist Christine Seidman.

Genetics 98

Genetics Research Cardiology 98

XTalks

NOVEMBER 26, 2024

BridgeBio has been highly active in the genetic diseases space. Its investigational therapy infigratinib recently received Breakthrough Therapy designation, becoming the first-ever potential treatment for achondroplasia — a genetic condition affecting bone growth — to achieve this milestone.

Genetic Disease 105

Genetic Disease Genetics Protein Clinical Development 105

Scienmag

MAY 5, 2021

Study published in JAMA Cardiology Credit: UIC/Jenny Fontaine A new mutation found in a gene associated with an increased risk of atrial fibrillation poses a significantly increased risk for heart failure in Black people.

Cardiology 53

Cardiology Genetics Gene Research 53

Scienmag

APRIL 28, 2021

In a world first study of 390,435 people, University of South Australia researchers found causal genetic evidence that cardio health […].

Genetics 52

Genetics Research Gene Cardiology 52

Medical Xpress

JANUARY 26, 2023

Research in a mouse model of diet-induced obesity has found greater disruption to genes involved in heart function when coupled with vitamin A deficiency using a combined dietary and genetic approach. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.

Genetics 109

Genetics Gene Research Cardiology 109

Medical Xpress

NOVEMBER 21, 2022

Hypertrophic obstructive cardiomyopathy (HOCM) is a common genetic condition that can cause fatigue, shortness of breath, fainting and chest pain, according to the American Heart Association.

Genetics 98

Genetics Cardiology 98

Scienmag

MARCH 31, 2021

Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure Credit: In-Hyuk Jung, PhD, Stitziel Lab High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke.

Scientist 62

Scientist Genetics Gene Medicine 62

Scienmag

AUGUST 20, 2020

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can […]. (..)

Genetics 41

Genetics Gene Genomics Genome 41

Scienmag

JUNE 3, 2021

Conducted in partnership with the University of Reading, the world-first study used a genetic-approach to investigate causal […].

Genetics 95

Genetics Research Cardiology Medicine 95

Scienmag

AUGUST 31, 2020

Sophia Antipolis, France – 31 Aug 2020: Losing weight could prevent or even reverse diabetes, according to late breaking research presented today at ESC Congress 2020.1 In 2019, approximately 463 million people worldwide had diabetes, of which the vast majority (around 90%) was type 2 diabetes.2

Genetics 72

Genetics Research Cardiology Medicine 72

Scienmag

NOVEMBER 18, 2020

— Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. ROCHESTER, Minn. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease ?

Genetics 40

Genetics RNA Protein Research 40

Medical Xpress

MAY 8, 2023

Asian Americans have significant differences in genetics, socioeconomic factors, culture, diet, lifestyle, health interventions and acculturation levels based on the Asian region of their ancestry that likely have unique effects on their risk for heart disease and Type 2 diabetes, according to a new American Heart Association scientific statement published (..)

Genetics 91

Genetics Cardiology 91

Scienmag

DECEMBER 10, 2020

Jefferson researchers find that the genetic underpinnings of a skin disorder at birth indicate future heart problems PHILADELPHIA – Our skin tells us when we’ve spent too much time in the sun or when the dry air of winter has sucked away too much moisture.

Genetics 75

Genetics Research Dermatology Cardiology 75

Medical Xpress

FEBRUARY 6, 2023

A genetic score may be able to identify higher stroke risk—but only for people living in the most privileged neighborhoods, according to new research that highlights inequities related to wealth and health.

Gene 75

Gene Genetics Research Cardiology 75

Scienmag

MAY 18, 2021

Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome. In recent years, the mix of these resident bacteria, and the […].

Bacteria 74

Bacteria Genetics Scientist Gene 74

Scienmag

FEBRUARY 17, 2021

In a world first genetic study, researchers from the Australian Centre for Precision Health at the University of South Australia found that that long-term, […].

Genetics 65

Genetics Research Cardiology Medicine 65

Scienmag

FEBRUARY 24, 2021

According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. Credit: UEF/Raija Törrönen.

Gene 52

Gene Genetics Regulation Cardiology 52

Scienmag

NOVEMBER 25, 2020

Boston, Mass. – Even as tens of thousands of Americans test positive for COVID-19 each day, physicians still aren’t sure why some people experience mild to no symptoms while others become critically ill. New research led by Robert E.

Genetics 49

Genetics Research Medicine Cardiology 49

The Pharma Data

OCTOBER 28, 2020

28, 2020 — There may be a positive causal relationship between elevated birth weight and risk for future atrial fibrillation in adulthood, according to a study presented at the annual Great Wall International Congress of Cardiology, held virtually from Oct. WEDNESDAY, Oct. The genome-wide association study included 321,223 individuals.

Cardiology 40

Cardiology Genetics Genomics Genome 40

XTalks

APRIL 15, 2021

Dr. Benoit Tyl, MD, FESC, medical and scientific director, cardiology at Servier, says that the disconnect between correlation and causality in cardiovascular disease trials is partially responsible for the lack of approved HFpEF therapies. Figure 1: The use of Mendelian randomization to validate genetic drug targets.

Development 98

Development Drugs Genomics Genome 98

The Pharma Data

OCTOBER 22, 2020

Pre-pregnancy care for a woman with known aortic disease would include evaluation of maternal and fetal risk, counseling and possible genetic testing, followed by ongoing monitoring and testing, study co-author Dr. Melinda Davis, a cardio-obstetrics expert at University of Michigan Medicine, said in a university news release. Source link.

Cardiology 52

Cardiology Hormones Genetics Research 52

Scienmag

OCTOBER 15, 2020

Benoit Bruneau and Katie Pollard study DNA folding to identify the genetic causes of congenital heart disease Credit: Photo: Gladstone Institutes SAN FRANCISCO, CA–October 15, 2020–The National Institutes of Health (NIH) has granted a 4D Nucleome award to support research by a group of scientists at Gladstone Institutes led by Benoit Bruneau, (..)

DNA 54

DNA Genetics Scientist Research 54

Scienmag

APRIL 20, 2021

Researchers at Penn Medicine uncover more genetic mutations that predispose women to peripartum cardiomyopathy, with implications for the future of increased genetic testing PHILADELPHIA– Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), (..)

Genetics 45

Genetics Development Medicine Research 45

Scienmag

DECEMBER 3, 2020

In a randomized, controlled clinical trial, researchers found that patients who received genetic test results about the side effects of cholesterol-lowering medications did not have worse outcomes after one year A person’s genetic make-up can influence whether they might experience side effects from certain medications.

Clinical Trials 44

Clinical Trials Clinical Trials Trials Genetics 44

Scienmag

DECEMBER 3, 2020

are entering into a collaboration to sequence the complete human genomes of thousands of consenting patients, in order to identify genetic alterations driving […].

Genomics 52

Genomics Genome Medicine Genetics 52

Scienmag

MAY 17, 2021

Patients’ genetic profile strongly influences size of effect in early-phase trial People with extremely high levels of triglycerides (a type of fat in the blood) and a specific genetic profile saw a substantial reduction in triglycerides after taking the human monoclonal antibody evinacumab compared with those taking a placebo, in a study presented (..)

Genetics 42

Genetics Antibody Trials Gene Therapy 42

Scienmag

FEBRUARY 17, 2021

A leading cause of SCD in young athletes is arrhythmogenic cardiomyopathy (ACM), a genetic disease in which healthy heart muscle is replaced over time […]. Credit: Mark Bauer/FSU College of Medicine Nearly a half-million people a year die from sudden cardiac death (SCD) in the U.S.

Medicine 55

Medicine Genetic Disease Development Genetics 55

XTalks

SEPTEMBER 4, 2024

The data, presented at the European Society of Cardiology Congress 2024, suggest that vutrisiran could significantly reduce the risk of death and heart-related issues, marking a potential treatment breakthrough.

Trials 52

Trials RNA Protein Gene Editing 52

XTalks

FEBRUARY 19, 2024

Aging, unhealthy lifestyles and genetics increase the risk of heart-related conditions. Related: Top 15 Cardiovascular Disease Drugs in 2023 by 2022 Sales Data Understanding Cardiovascular Disease Trends The US faces a worrying trend in cardiovascular disease, affecting a large part of the population.

Pharmacy 98

Pharmacy Genetics Sales Drugs 98

Scienmag

JANUARY 14, 2021

14, 2021 — Adults who smoke or who are genetically predisposed to smoking behaviors are more likely to experience a serious type of stroke called subarachnoid hemorrhage (SAH), according to new research published today in Stroke, a journal of the American Stroke Association, a division of the American Heart Association. […].

Genetics 46

Genetics Research Cardiology Medicine 46

pharmaphorum

AUGUST 13, 2020

Adding in Regeneron’s antibody resulted in a 49% drop in cholesterol levels from the start of the study compared to patients sticking with their current therapy alone, according to results presented earlier this year at the American College of Cardiology’ congress in March.

Drugs 52

Drugs Antibody Sales Cardiology 52