XTalks

DECEMBER 26, 2024

The BROADWAY trial tested obicetrapib, a novel cholesteryl ester transfer protein (CETP) inhibitor, as a monotherapy in adult patients with heterozygous familial hypercholesterolemia (HeFH) or atherosclerotic cardiovascular disease (ASCVD). Unlike CETP inhibitors, PCSK9 inhibitors block a protein that regulates cholesterol levels.

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Scienmag

MARCH 1, 2021

Peer Reviewed Experimental Animals Consumption of a high fat diet may be activating a response in the heart that is causing destructive growth and lead to greater risk of heart attacks, according to new research.

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Protein Research Cardiology Medicine 51

XTalks

SEPTEMBER 4, 2024

The data, presented at the European Society of Cardiology Congress 2024, suggest that vutrisiran could significantly reduce the risk of death and heart-related issues, marking a potential treatment breakthrough. Vutrisiran works by silencing the gene responsible for producing TTR, reducing both mutant and wild-type TTR proteins.

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Scienmag

DECEMBER 2, 2020

Mutations in CHD7 cause severe birth defects known as CHARGE syndrome cases, which include severe and life-threatening heart malformations. Credit: UAB BIRMINGHAM, Ala. – Research by Kai Jiao, M.D.,

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Medical Xpress

JANUARY 20, 2023

In their paper published in the journal Science, the group describes using the gene editing system to modify two bases in the mouse genome to prevent hyperactivation of a protein that can lead to heart disease.

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Gene Editing Genome Genomics Gene 80

Scienmag

OCTOBER 12, 2020

JNeurosci 2020 In Alzheimer’s disease, impaired blood flow to brain regions coincides with tau protein buildup. and tau protein accumulate as Alzheimer’s disease […]. As Alzheimer’s disease progresses, more brain regions exhibit the relationship Credit: Albrecht et al., Vascular function declines and amyloid-?

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Protein Research Cardiology Medicine 57

Medical Xpress

NOVEMBER 7, 2022

A single IV infusion of NTLA-2001, a novel CRISPR/Cas9-based gene editing therapy, significantly reduced circulating transthyretin (TTR) protein levels in patients with ATTR amyloid cardiomyopathy, a progressive and fatal cause of heart failure, according to late-breaking research presented today at the American Heart Association's Scientific Sessions (..)

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Scienmag

JANUARY 15, 2021

Scientific Reports publishes the first study to analyze the relationships among proteomic signatures, religion and spirituality and risk of developing a clinical condition BOSTON – The Study on Stress, Spirituality and Health (SSSH), a cutting-edge proteomics analysis, suggests that religious beliefs modulate protein expression associated with (..)

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The Pharma Data

NOVEMBER 30, 2020

. “It’s well known that diet plays a critically important role in the development of heart disease and stroke,” said Dr. Amit Khera, professor of medicine and director of the preventive cardiology program at the University of Texas Southwestern Medical Center in Dallas. “This is a reminder that diet is important.

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Scienmag

APRIL 28, 2021

For the first time, researchers have identified the specific mechanism of von Willebrand Factor (vWF) — an essential blood clotting protein — that enables it to bind to platelets and initiate clotting Under normal, healthy circulatory conditions, the von Willebrand Factor (vWF) keeps to itself.

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Scienmag

OCTOBER 7, 2020

Collaborative projects funded by the awards will address important questions about neurodegenerative disease, nucleus biology, and protein turnover Credit: Dollie LaJoie, Huntsman Cancer Institute at the University of Utah Could scientists detect neurodegenerative diseases like Alzheimer’s and ALS years or decades before these disorders manifest (..)

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Delveinsight

AUGUST 4, 2020

MorphoSys in-licensed Monjuvi, which is a humanized Fc-engineered monoclonal antibody against CD19 – the same protein which CAR-T cell therapies target and is in abundance in cancerous B cells, from Xencor in 2010 and is under evaluation in B-cell malignancies in several ongoing combination trials.

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Scienmag

DECEMBER 18, 2020

Scientists made the finding by running fluid spiked with a COVID-19-like protein through a 3D-printed model of the arteries of a patient who had suffered […].

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pharmaphorum

MAY 18, 2021

Patients in the study were also presenting with elevated high-sensitivity C-reactive protein (hsCRP), showing they are at high cardiovascular risk. Data were announced at the virtual American College of Cardiology annual conference and published simultaneously in The Lancet.

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Drugs Cardiology Trials Clinical Trials 52

Scienmag

NOVEMBER 18, 2020

This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease ? and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy. Dilated cardiomyopathy […].

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Scienmag

MAY 18, 2021

Predictions from this […].

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Protein Research Cardiology Engineer 43

Scienmag

MAY 13, 2021

Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells.

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Protein Scientist Medicine Research 40

Scienmag

SEPTEMBER 15, 2020

Circulation: Cardiovascular Imaging Journal report DALLAS, September 15, 2020 — Patients with psoriasis treated with biologic therapy, which are protein-based infusions to suppress inflammation, had a significant reduction in high-risk plaque in heart arteries, over one-year, according to new research published today in Circulation: Cardiovascular (..)

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Protein Research Cardiology Medicine 40

Scienmag

SEPTEMBER 2, 2020

A particular protein triggers a part of our immune system that can boost the blood’s tendency to coagulate and form clots. Why so many COVID-19 patients get blood clots (thrombosis) remains uncertain. But scientists at Uppsala University and the University Hospital have now identified a mechanism they believe to be implicated.

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The Pharma Data

NOVEMBER 9, 2020

Researchers also looked at their levels of fibrinogen, a blood plasma protein that is considered a marker for inflammation. Researchers tracked the study’s participants over 26 years of follow-up, during which 378 people died from heart disease.

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Medicine Cardiology Research Protein 52

XTalks

SEPTEMBER 26, 2024

Here are a few simple, effective ways to help maintain heart health: Eat a b alanced d iet: Incorporate fruits, vegetables, whole grains and lean proteins into meals while reducing salt, sugar and unhealthy fats. Steps to Improve Heart Health Protecting heart health doesn’t have to be complicated.

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The Pharma Data

MARCH 17, 2022

The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on haematology, nephrology, neurology, metabolic disorders, cardiology and ophthalmology.

Cardiology 52

Cardiology Medicine Development Protein 52

The Pharma Data

AUGUST 22, 2021

The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on haematology, nephrology, neurology, metabolic disorders, cardiology, and ophthalmology.

Trials 52

Trials Clinical Trials Clinical Trials Cardiology 52

Delveinsight

AUGUST 3, 2021

According to analyst views, interventional cardiology sales grew at around 7% in the first quarter of 2021 versus 2020 with structural heart franchise WATCHMAN, ACURATE neo2, and SENTINEL. The company expects full-year growth versus 2019 on the back of new product launches. MeMed obtains CE mark for its Test Predicting COVID-19 Severity.

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XTalks

JANUARY 3, 2025

Tryngolza works by targeting a protein in the liver, apoC-III, which regulates triglyceride metabolism. People with FCS often have triglyceride levels higher than 880 mg/dL, compared to a healthy target level of below 150 mg/dL. FCS also severely impacts quality of life, causing chronic fatigue and recurrent stomach pain.

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The Pharma Data

SEPTEMBER 5, 2021

The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on haematology, nephrology, neurology, metabolic disorders, cardiology and ophthalmology.

Clinical Trials 52

Clinical Trials Clinical Trials Cardiology Medicine 52

The Pharma Data

APRIL 28, 2022

The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on haematology, nephrology, neurology, metabolic disorders, cardiology and ophthalmology.

Antibody 52

Antibody Trials Medicine Cardiology 52

The Pharma Data

APRIL 4, 2023

2,3 Approximately three-quarters of people with NMOSD are anti-AQP4 Ab+, meaning they produce antibodies that bind to a specific protein, aquaporin-4 (AQP4). The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system.

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Trials Medicine Antibody Clinical Trials 40

XTalks

AUGUST 2, 2023

Johnson & Johnson’s Top 5 Best-Selling Drugs of 2022: 1) Stelara (ustekinumab) Stelara is an immunosuppressant biologic therapy that blocks the IL-12 and IL-23 proteins that play a role in plaque psoriasis and Crohn’s disease. The monoclonal antibody targets CD20, a protein found on the surface of B lymphocytes (B cells).

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The Pharma Data

NOVEMBER 4, 2020

The antibody is designed to bind to misfolded light chain protein and amyloid and shows binding to both kappa and lambda subtypes. CAEL-101 is a first-in-class monoclonal antibody (mAb) designed to improve organ function by reducing or eliminating amyloid deposits in the tissues and organs of patients with AL amyloidosis.

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The Pharma Data

DECEMBER 8, 2020

The company’s commercial priorities are three-fold: (1) Initially focusing its commercial efforts on rare diseases within its prolific neurology and cardiology franchises (2) pioneer new markets where there are no available treatments (3) create new standards of care where there has been a lack of innovation to optimize patient care. .

Medicine 52

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The Pharma Data

AUGUST 30, 2021

Results were presented at the ESC Congress 2021, organized by the European Society of Cardiology (ESC). Leqvio works differently from other therapies by preventing the production of the target protein in the liver, increasing hepatic uptake of LDL-C and clearing it from the bloodstream 17.

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RNA Trials Production Containment 52

The Pharma Data

NOVEMBER 4, 2020

The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. About ULTOMIRIS ®. About SOLIRIS ®.

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Doctors Doctor Vaccine Vaccination 52

XTalks

FEBRUARY 8, 2024

for a one-month supply Why it did so well: Jardiance belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, inhibiting the SGLT2 protein in the kidneys to lead to the excretion of excess glucose through the urine. Jardiance brought in $2.06 billion for Eli Lilly and $6.23 billion for Boehringer Ingelheim.

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Sales Insulin FDA Approval Drugs 52

The Pharma Data

SEPTEMBER 15, 2020

20vPnC showed a safety and tolerability profile that was similar to Prevnar 13 ® Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]. The team shared results from a Phase 2a study that was conducted by Akcea Therapeutics/Ionis Pharmaceuticals and previously disclosed at the recent European Society of Cardiology Congress 2020.

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Gene Therapy Vaccine Vaccination Trials 52

Scienmag

JULY 19, 2021

May also explain liver fat differences among men & women Credit: Sallam Lab/UCLA FINDINGS A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells’ protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver (..)

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The Pharma Data

MAY 13, 2021

Journal of the American College of Cardiology. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Clinical impact of Mediterranean-enriched-protein diet on liver size, visceral fat, fat mass, and fat-free mass in patients undergoing sleeve gastrectomy.

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