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Inhibition of proteins activated by nitric oxide reverses aortic aneurysm in Marfan syndrome

Scienmag

The researchers have demonstrated that silencing or inhibiting the activity of these proteins completely reverses the aortic disease in a mouse model of Marfan Syndrome Credit: CNIC Scientists at the Centro Nacional de Investigaciones Cardiovasculares Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) have discovered that the nitric oxide (NO) (..)

Protein 96
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Scientists’ discovery of blood clotting mechanism could lead to new antithrombotic drugs

Scienmag

For the first time, researchers have identified the specific mechanism of von Willebrand Factor (vWF) — an essential blood clotting protein — that enables it to bind to platelets and initiate clotting Under normal, healthy circulatory conditions, the von Willebrand Factor (vWF) keeps to itself.

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The Paul G. Allen Frontiers Group announces new Allen Distinguished Investigators

Scienmag

Collaborative projects funded by the awards will address important questions about neurodegenerative disease, nucleus biology, and protein turnover Credit: Dollie LaJoie, Huntsman Cancer Institute at the University of Utah Could scientists detect neurodegenerative diseases like Alzheimer’s and ALS years or decades before these disorders manifest (..)

Protein 52
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A step toward understanding why COVID-19 boosts stroke risk

Scienmag

Scientists made the finding by running fluid spiked with a COVID-19-like protein through a 3D-printed model of the arteries of a patient who had suffered […].

Protein 52
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Molecular alteration may be cause — not consequence — of heart failure

Scienmag

Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells.

Protein 40
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Possible blood-clotting mechanism in COVID-19 found

Scienmag

But scientists at Uppsala University and the University Hospital have now identified a mechanism they believe to be implicated. A particular protein triggers a part of our immune system that can boost the blood’s tendency to coagulate and form clots. Why so many COVID-19 patients get blood clots (thrombosis) remains uncertain.

Protein 40
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Top 30 Pharma and Biotech Companies in 2023: Statistics and Trends

XTalks

Johnson & Johnson’s Top 5 Best-Selling Drugs of 2022: 1) Stelara (ustekinumab) Stelara is an immunosuppressant biologic therapy that blocks the IL-12 and IL-23 proteins that play a role in plaque psoriasis and Crohn’s disease. The monoclonal antibody targets CD20, a protein found on the surface of B lymphocytes (B cells).

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