Worldwide Clinical Trials

JUNE 21, 2024

The 2024 ASCO Annual Meeting from the American Society of Clinical Oncology is a fantastic platform for clinical researchers to discuss the latest advancements and challenges in oncology research. ADCs are continually evolving, bringing forward new targets across various cancer types, including rare and orphan cancers.

Antibody 162

Antibody Clinical Trials Clinical Trials In-Vitro 162

Pharmaceutical Technology

OCTOBER 26, 2022

Gene therapy uses DNA to manipulate cells and correct defective genes, whereas cell therapy is the infusion or transplantation of cells into a patient. Early gene therapy methods were proposed in the 1970s, and the first approved gene therapy clinical research in the US began in 1990. The future of cell and gene therapies.

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Gene Therapy Gene Marketing Manufacturing 130

VirTrial

OCTOBER 14, 2020

Verifiable and accessible in real-time, Investigator sites will also benefit by having employer’s VirTrial certifications as part of their dynamic research ready auditable (HR) GDPRDirectory® commonly used for business and compliance tracking, all from one place.”. That’s why we provide our Virtual Trial Capable training for sites.”

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Compliance Clinical Research Clinical Trials Clinical Trials 98

Advarra

MARCH 31, 2023

Among the various regulatory bodies providing oversight on clinical research, only the institutional biosafety committee (IBC) has a purview specific to research involving engineered genetic materials. The post Risk Assessment for use of Engineered Genetic Materials in Clinical Research appeared first on Advarra.

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Engineer Genetics Clinical Research Research 52

BioSpace

SEPTEMBER 15, 2020

Hexagon Bio, a California-based biotechnology company turning nature’s DNA into medicines for cancers and infectious diseases with unmet needs, will move into clinical research with $47 million in Series A financing.

DNA 53

DNA Clinical Research Medicine Research 53

pharmaphorum

AUGUST 5, 2021

Critical cellular processes including DNA replication and translation cannot occur without functional-specific proteins. Novel approaches to optimise PPIs: Meeting a clinical demand . A recent clinical research paper highlights the importance of targeting of PPIs in stem cells of cancer. Charlotte Di Salvo.

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Protein Gene Bioassay DNA 126

XTalks

MAY 23, 2024

This expansion is triggered by somatic mutations — changes that occur in the DNA post-fertilization and are not inherited from parent to offspring. The ideal approach to distinguish these mutations involves comprehensive genomic profiling, where both tumor DNA and germline (blood) DNA are sequenced.

Genetics 114

Genetics Research Genomics Genome 114

pharmaphorum

DECEMBER 17, 2021

Digital health and technologies offer a wealth of opportunities, but digital needs to become part of a company’s DNA to achieve transformation, says Boston Scientific’s Rodamni Peppa. Optimised clinical research through decentralised trials. Pushing the right buttons for transformative digital health.

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Clinical Trials Clinical Trials Medicine DNA 98

XTalks

JANUARY 8, 2024

“It’s important to make sure that with this increase in clinical trial complexity, we don’t make our trials overly burdensome to sites or patients,” says Markham. Keeping Trials on Track The preparation and analysis of samples within tight clinical trial timelines are crucial.

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Clinical Trials Clinical Trials Trials Gene Therapy 105

WCG Clinical

JUNE 24, 2024

In 1953, Watson and Crick formulated the current description of DNA as a double helix 1 and soon thereafter experiments with restriction endonucleases gave scientists the ability to modify and manipulate DNA 2. 2008) Discovery of DNA structure and function: Watson and Crick. References Pray, L. Nature Education 1(1):100 Wil A.

DNA 52

DNA Regulation Scientist Research 52

XTalks

FEBRUARY 4, 2021

Bernard, executive vice president for research and chief research officer at Vanderbilt University Medical Center, shared his experience in helping set up a DNA and clinical data resource called BioVU. Dr. Bernard’s clinical research interests are in the areas of sepsis and acute respiratory distress syndrome (ARDS).

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Research Biobanking Drugs Genomics 98

pharmaphorum

MARCH 31, 2022

UK startup Sano Genetics has raised $11 million in first-round financing to develop its go-between service, which aims to overcome one of the big challenges in clinical research by connecting patients with trial sponsors. There’s no cost to participants, but study sponsors pay a subscription fee to access the patient database.

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Trials Genetics DNA Clinical Trials 52

Find Me Cure

OCTOBER 13, 2019

This Breast Cancer Awareness Month we’d like to talk about emerging areas in metastatic breast cancer treatment since clinical research has come so far in recent years. An enzyme involved in DNA repair can be the key to making chemotherapy more effective. Using the immune system against the cancer cells.

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Development DNA Clinical Trials Clinical Trials 52

XTalks

DECEMBER 28, 2023

. “We are extremely proud to play a critical role in this clinical trial with the UNITY Fetal Antigen CTA test,” said Oguzhan Atay, CEO of BillionToOne in the company’s press release. “The ability to detect fetal antigens as early as ten weeks is only made possible due to our expertise in fetal DNA quantification.

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Trials Clinical Trials Clinical Trials Antibody 97

WCG Clinical

AUGUST 27, 2024

The NIH Guidelines also stipulate that at least two members of each IBC come from the surrounding community and be unaffiliated with the institution where the research is occurring apart from their membership on the IBC. Question: Why do community members need to participate in IBC review meetings?

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Genetic Engineering Engineer Compliance Genetics 52

Advarra

JUNE 12, 2023

Gene therapy research is exciting and full of promise, but because of the risks involved, it’s also highly regulated, requiring an institutional biosafety committee (IBC) to provide additional oversight and risk assessment.

Genetic Engineering 98

Genetic Engineering Gene Therapy Genetics Engineer 98

The Pharma Data

JUNE 24, 2021

The study will evaluate the efficacy and safety of talazoparib, an oral poly (ADP-ribose) polymerase (PARP) inhibitor, in combination with enzalutamide, an androgen receptor inhibitor, compared with placebo plus enzalutamide in men with DNA damage response (DDR)-deficient metastatic castration-sensitive prostate cancer (mCSPC).

DNA 52

DNA Clinical Trials Clinical Trials Trials 52

pharmaphorum

AUGUST 27, 2020

For example, if a company is carrying out clinical trials, then a clinical research organisation is needed to run them. Today researchers are attaching only a portion of the DNA or mRNA of the virus to a harmless molecule. This precision has significant advantages in efficacy and production.

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Vaccine Vaccination Life Science Clinical Trials 122

XTalks

NOVEMBER 7, 2022

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. The cfDNA that originates from tumors is called circulating tumor DNA (ctDNA). These tumor-derived entities are used to derive genomic and proteomic data.

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Clinical Trials Clinical Trials Trials FDA Approval 98

The Pharma Data

OCTOBER 18, 2020

(NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. Telomeres are “caps” at the end of chromosomes that protect DNA from getting worn away as cells replicate.

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DNA Scientist Genetic Disease Research 52

pharmaphorum

DECEMBER 20, 2022

Another focus is ensuring that we remain world-leading in our current research and clinical programmes by investing in infrastructure, the newest technologies and by continuing to develop and recruit the most outstanding scientists and clinician-scientists. A fresh approach.

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Scientist Research Genetics Drugs 98

Roots Analysis

AUGUST 28, 2022

As a result, industry and non-industry stakeholders, are on the lookout for advanced platforms that can simultaneously capture the arrangement of multiple biomolecules (DNA, RNA, proteins and others) with single-cell or subcellular resolution. 70+ spatial Genomics solutions are developed by industry and non-industry players.

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Genomics Genome RNA Genome Project 52

pharmaphorum

JANUARY 18, 2023

The DNA of these so-called ‘genetic superheroes’ may contain clues about how to treat severe disease. By studying their natural resilience and using it to design new therapies, it could help so many people. And if participants have opted in to be made aware of their risks of genetic diseases, then communication has to be carefully considered.

Genetic Disease 97

Genetic Disease Genetics Research Genome 97

Cloudbyz

NOVEMBER 3, 2021

Biosamples and biomarkers are the core basis for much of the work done in the clinical research industry and proficient Human Biosample Management (HBSM) is necessary to procure reliable biosamples. For a rapidly growing subfield of clinical research such as HBSM, the long-term future can be very difficult to predict.

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Biobanking Clinical Research Research Contamination 52

XTalks

FEBRUARY 13, 2023

Radiation causes single and double strand breaks in DNA and radiation damage to cells can occur from a direct or indirect action of radiation on DNA molecules. When radiation directly hits the DNA molecule, this disrupts the molecular structure of the DNA and this structural change to the DNA can lead to cell damage or apoptosis.

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Clinical Trials Clinical Trials Trials DNA 52

Roots Analysis

NOVEMBER 5, 2023

Challenges Faced in Liquid Biopsy Market Non invasive cancer diagnostics market have captured significant attention of researchers across the globe, paving the way for more innovations in this domain. However, there are several challenges that needs to be addressed before novel technologies replace the traditional biopsies.

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Marketing Genetics DNA Research 40

pharmaphorum

APRIL 14, 2022

Benefits of attending: •Listen to case studies presenting on pre-clinical and clinical research in areas such as oncology and what can be learned for future clinical trials.

RNA 52

RNA Clinical Trials Clinical Trials Life Science 52

Advarra

JUNE 13, 2024

Recombinant DNA technologies and genetically modified biological agents are being adapted for a wide scope of therapeutic applications, and their use is becoming increasingly common in clinical trials. Synthetic mRNA-based therapeutics used in clinical research today also fall into this self-limiting class of recombinant therapeutics.

Genetic Engineering 52

Genetic Engineering Clinical Trials Clinical Trials Engineer 52

XTalks

DECEMBER 14, 2023

In a statement , USWM said it partnered with the Beat Childhood Cancer Research Consortium at Penn State University, which “conducted the preclinical and clinical research to help advance this vital therapy. The disease is aggressive and difficult to treat with limited treatment options.

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FDA Approval Dermatology Drugs DNA 52

The Pharma Data

OCTOBER 14, 2020

The new services have been developed to support pre-clinical research by optimizing hiPSC-derived cell culture, while providing high-quality electrophysiological data acquisition and analysis from physiologically relevant human cell models. Axol Bioscience – Based in the U.K.,

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Clinical Trials Clinical Trials Manufacturing In-Vivo 52

Advarra

AUGUST 10, 2023

However, recent advancements in the clinical use of recombinant DNA (rDNA) technology creates opportunities for changing this calculation and addressing a great, unmet medical need. “I The project should also help clinical research sponsors take advantage of various FDA pathways for accelerated review and approval.

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Gene Therapy Development Gene Drugs 52

Cloudbyz

JULY 31, 2024

This revolution is enabling the growth of innovative biomarker-based precision medicine and cell and gene therapy, transforming both clinical research and post-market care. The landscape of modern medicine is rapidly evolving, driven by groundbreaking advancements in diagnostics.

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Gene Therapy Gene Medicine In-Vitro 52

The Pharma Data

DECEMBER 20, 2020

eTrueNorth is actively recruiting COVID-19-positive patients about potential participation in the NIH’s ACTIV-2 clinical research trial. The data demonstrated the vaccine elicited a combined adaptive humoral and cellular immune response and also provided insights into the composite nature of BNT162b2-induced T-cell immunity.

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Trials Gene Therapy Vaccine Vaccination 52

XTalks

OCTOBER 1, 2020

Lin has made several transitions throughout her career, from being a clinician at an academic center, to academic research, to heading business development in industry. At Nurix, Dr. Hansen focuses on establishing the company’s DNA-encoded library technology platform for small molecule identification and leading the discovery organization.

Scientist 52

Scientist In-Vitro Research Life Science 52

XTalks

MAY 12, 2022

XTALKS WEBINAR: Using the Pain Catastrophizing Scale in Clinical Research and Practice. The detergent will denature the proteins and result in the release of the viral genomic DNA. The developed primers or the capture oligonucleotides will target and bind to the viral DNA and thus, they will form a hybrid called an amplicon.

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In-Vitro DNA Development Genome 52

The Pharma Data

MARCH 9, 2021

Lenacapavir is a potential first-in-class capsid inhibitor that is designed to inhibit HIV replication as it interferes with the disassembly of the HIV capsid core, inhibits the role of capsid proteins during viral RNA/DNA translocation to the nucleus, and disrupts assembly of the capsid core.

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Drugs RNA Trials Development 52

Pharmaceutical Technology

FEBRUARY 20, 2023

We look forward to deepening our collaboration in next decades and contributing more to state-of-the-art clinical trials for efficient medicine to patients’ benefits throughout the world”, says XU Yi, CEO Teddy Clinical Research Laboratory. SZ) and Tigermed (300347.SZ

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