Worldwide Clinical Trials

JULY 29, 2024

Evolving sentiments recognize obesity as a medical condition and lifestyle choice as well as a chronic disease with genetic, psychological, cultural, and environmental causes (Figure 1). DEXA (Dual-Energy X-ray Absorptiometry) is the optimal method for accurately measuring body composition in clinical research.

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Clinical Research Research Clinical Trials Clinical Trials 130

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 25, 2024

A woman in Colombia with rare genetic resistance to Alzheimer’s disease may have more company than scientists thought.

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Gene Genetics Scientist Research 245

Worldwide Clinical Trials

FEBRUARY 6, 2023

When using genetic screening to identify clinical trial volunteers, a sponsor’s obligations for further testing and disclosure of results to patients and families are unclear, especially when the results have no impact on medical management. Guidance in this area is much needed. Read the full article! Read the full article!

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Genetics Clinical Trials Clinical Trials Genotype 130

Scienmag

JULY 12, 2022

July 11, 2022, CLEVELAND: New research from Cleveland Clinic is demonstrating that pathogenic polymerase epsilon and delta (POLE/POLD1) genetic mutations lead to improved response to immune checkpoint blockade, a powerful class of immunotherapy drugs.

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Genetics Clinical Research Research Drugs 79

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 29, 2024

A unique genetic mutation in two siblings – that has never been seen in anyone else – has been discovered by UK researchers at the University of Exeter, pointing the way towards new treatment options for type 1 diabetes. The mutation is in the gene for a protein called programmed death-ligand 1 (PD-L1), and a […]

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Gene Genetics Protein Research 243

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 22, 2024

(Richard Jones/Science Photo Library/Getty Images) Scientists have discovered hundreds of genes that could potentially promote cancer, new research shows. Cancer is typically triggered by some kind of change to our genetic coding that interferes with a cell’s ability to manage its growth.

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Scientist Gene Genetics Research 244

XTalks

MAY 23, 2024

One of the more intriguing developments in cancer research in recent years is the growing understanding of clonal hematopoiesis, a phenomenon where blood cells expand from a single clone due to genetic mutations. Clonal hematopoiesis increases in prevalence with age and can precede hematologic malignancies.

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Genetics Research Genomics Genome 114

Scienmag

JULY 22, 2021

of Mayo Clinic Cancer Center, along with collaborators from the CARRIERS consortium, suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study was published Thursday, July 22, in the Journal of Clinical Oncology. . — A new study by Fergus Couch, Ph.D.,

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Genetics Clinical Research Research Medicine 74

Worldwide Clinical Trials

OCTOBER 14, 2024

Fortunately, advances in clinical research are providing hope for better treatments and outcomes. With the support of global networks like ours at Worldwide Clinical Trials (Worldwide), autoimmune and bone health research is accelerating, providing new solutions to patients around the world.

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Research Clinical Trials Clinical Trials Immune Response 147

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 7, 2023

New research from ETH Zürich in Switzerland could see future wearable devices (with perhaps a few implants and a touch of genetic engineering) boost our health directly. Fitness trackers help you stay healthy by keeping count of your steps and monitoring your heart rate, driving you on to hit those cardio goals.

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Genetic Engineering Gene Engineer Genetics 246

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 25, 2023

Scientists from the US, UK, and Uruguay analyzed data from 378,932 people aged 40 to 69 to see how those who are genetically ‘programmed’ to nap regularly fared cognitively […]

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Genetics Scientist Clinical Trials Clinical Trials 246

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 17, 2024

Similar genetic changes in two different types of brain cells may contribute to cognitive impairment in schizophrenia and aging. US researchers examined gene expression in more than a million brain cells collected post-mortem from 191 donors.

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Gene Expression Gene Genetics Research 242

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 8, 2023

As DNA holds the genetic code controlling how our bodies grow and are maintained, that’s a serious problem that […] The artificial sweetener sucralose (marketed as Splenda) is widely used and found in products like diet soda and chewing gum.

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DNA Scientist Genetics Production 245

Worldwide Clinical Trials

OCTOBER 14, 2024

Fortunately, advances in clinical research are providing hope for better treatments and outcomes. With the support of global networks like ours at Worldwide Clinical Trials (Worldwide), autoimmune and bone health research is accelerating, providing new solutions to patients around the world.

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Research Clinical Trials Clinical Trials Immune Response 130

XTalks

SEPTEMBER 9, 2024

Diversity, equity and inclusion (DEI) have become important elements in the landscape of clinical research. Xtalks spoke with Stacy Weil, DHI, Senior Vice President, Business Operations and Patient Centricity, Premier Research, to gain insights into incorporating DEI practices and plans in clinical research.

Clinical Research 101

Clinical Research Research Clinical Trials Clinical Trials 101

Pharmaceutical Technology

OCTOBER 18, 2022

CSF biomarkers have been a popular area of interest in neurodegenerative disease research with previous studies related to Alzheimer’s and Multiple Sclerosis exploring the potential of their use. In PD clinical research, many biomarkers, such as neurofilament, can be measured within the CSF using a lumbar puncture.

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Protein Genetics Gene Clinical Research 264

Cloudbyz

JUNE 26, 2023

Generative artificial intelligence (AI) techniques are increasingly being applied in clinical research to enhance various aspects of medical data analysis, diagnosis, treatment planning, and drug discovery. These notes have been used to advance research in NLP and clinical decision support systems.

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Clinical Research Research Clinical Trials Clinical Trials 97

pharmaphorum

JANUARY 18, 2023

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. Giving participants something in return.

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Genetic Disease Genetics Research Genomics 97

Medical Xpress

MAY 16, 2023

Researchers from the Department of Molecular Biology and Genetics at Koc University in Turkey and the Pole of Endocrinology, Diabetology and Nutrition, Institute of Experimental and Clinical Research at Université Catholique de Louvain in Belgium, have collaborated to interrogate the mechanisms behind a cancer-associated wasting syndrome—cachexia. (..)

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Genetics Clinical Research Research 141

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 30, 2024

The current research areas of interest in India include precision medicine which treatments based on individual genetic profiles to improve […] The development of innovative therapeutic approaches in healthcare encompass a variety of fields, including gene therapy, personalized medicine, immunotherapy, and advanced biologics.

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Medicine Research Gene Therapy Genetics 189

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials.

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Engineer Genetics Clinical Research Research 52

Outsourcing Pharma

DECEMBER 1, 2022

ALS genetic carrier finds value in EverythingALS study leveraging digital biomarkers as a means to create tools for early detection of ALS and potentially other neurological diseases.

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Genetics Clinical Research Research Regulation 59

AuroBlog - Aurous Healthcare Clinical Trials blog

MAY 30, 2024

Around 8% of human DNA is made up of genetic sequences acquired from ancient viruses. Our latest research suggests that some ancient viral DNA sequences in the […]

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DNA Genomics Genome Genetics 188

Medical Xpress

JANUARY 5, 2023

National Institutes of Health researchers have published an assessment of 13 studies that took a genotype-first approach to patient care. This approach contrasts with the typical phenotype-first approach to clinical research, which starts with clinical findings.

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Genomics Genome Genetics Genotype 75

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 11, 2024

The Union ministry of health and family welfare (MoHFW) included primary hyperoxaluria, a rare genetic metabolic disorder that affects kidney and other organ systems, under the National Policy for Rare Diseases (NPRD), 2021, with financial assistance to be provided for transplants.

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XTalks

DECEMBER 12, 2024

In clinical research, this includes designing trials that elevate the patient voice, reduce barriers to participation, and represent the diverse populations who will ultimately use these medical products. These collaborations align research goals with community needs and regulatory expectations.

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Clinical Trials Clinical Trials Clinical Research Trials 59

Pharmaceutical Technology

JUNE 16, 2023

The Abu Dhabi Department of Health (DoH) in the UAE has made a declaration of collaboration with Mass General Brigham’s (MGB) International Center for Genetic Disease (iCGD) to advance life sciences.

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Life Science Genetic Disease Genomics Genome 130

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 19, 2023

Genetic inheritance is a physical link that tethers our birth parents; one-half of two sets of chromosomes meshing together to form our own unique set of molecular instructions for life.

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Gene Genetics Clinical Trials Clinical Trials 187

Olympian Clinical Research

SEPTEMBER 27, 2023

While the exact cause of vitiligo remains a subject of ongoing research, genetics has emerged as a significant factor in understanding its onset and progression. In this deep dive, we’ll explore the genetic links associated with vitiligo and address the burning question: Is vitiligo hereditary?

Genetics 52

Genetics Gene Clinical Research Research 52

XTalks

OCTOBER 22, 2024

Recruitment and Selection of Participants Obesity affects people across different ages, ethnicities and socioeconomic backgrounds, each with distinct genetic, environmental and behavioral factors contributing to their condition. How Advanced Clinical Practitioners (ACPs) drive efficiency and success in obesity clinical trials.

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Clinical Trials Clinical Trials Trials Clinical Research 105

ACRP blog

MARCH 26, 2025

Everyone should have the same opportunity to learn about and participate in clinical trials regardless of race, ethnicity, age, or gender, says Rochelle Williams-Belizaire, a clinical research professional and health equity strategist.

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Clinical Research Research Clinical Trials Clinical Trials 59

XTalks

APRIL 13, 2022

About 80 percent of rare diseases have a genetic basis. Most rare diseases are chronic conditions, and many are clinically progressive and potentially fatal. Aspects of Pediatric Medical Research. Challenges in Pediatric Rare Disease Clinical Trials. Trial Considerations for Pediatric Rare Disease Clinical Research.

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Clinical Trials Clinical Trials Clinical Research Trials 98

XTalks

DECEMBER 9, 2024

This initiative is particularly impactful for rare diseases and genetic disorders, where traditional endpoints may be infeasible. Programs like the Rare Disease Endpoint Advancement Pilot encourage collaboration with the FDA to establish novel surrogate endpoints.

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WCG Clinical

OCTOBER 8, 2024

Latin America’s genetic diversity and unique health challenges are driving groundbreaking clinical research, offering new insights into disease prevention, innovative medicine, and treatments. The region’s drive for the development of innovative treatment and prevention strategies contributes to the advancement of global health.

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Pharma Mirror

NOVEMBER 16, 2021

Rockville, Emmes, a global, full-service Clinical Research Organization dedicated to supporting the advancement of public health and biopharmaceutical innovation, today announced a partnership with MedGenome aimed at accelerating breakthrough treatments, powered by human genomics, for rare disease patients.

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Genomics Genome Research Genetics 130

Pharma Mirror

MAY 7, 2021

This accreditation recognizes that Avance Clinical has the CRO resources and internal processes in place to effectively manage pre-clinical and clinical trials for products involving genetically modified organisms (GMOs). The post Avance Clinical Expands Gene Technology Clinical Trial Services to Meet $17.4

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Clinical Trials Clinical Trials Gene Marketing 130

Advarra

SEPTEMBER 19, 2024

Achieving diversity, equity, and inclusion (DEI) in clinical trials is crucial for producing comprehensive and effective medical research benefitting all communities. DEI ensures clinical research encompasses diverse populations, considering variations in gender, race, ethnicity, socioeconomic status, and more.

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