XTalks

NOVEMBER 15, 2024

These RXR receptors play a key role in regulating transcription pathways involved in inflammation and immune responses, among other cancer hallmarks, to modulate the tumor microenvironment. Tamibarotene is a selective agonist of retinoic acid receptor alpha/beta, with potential binding to retinoid X receptors (RXR).

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XTalks

OCTOBER 24, 2024

Trends in Psoriasis Research: Biologics, Biosimilars and New Therapies Recent innovations in biologics and biosimilars have transformed psoriasis care. In August 2024, Artax Biopharma completed patient recruitment for its Phase IIa trial of AX-158, exploring a new immune-modulating therapy for psoriasis.

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Worldwide Clinical Trials

JUNE 21, 2024

The 2024 ASCO Annual Meeting from the American Society of Clinical Oncology is a fantastic platform for clinical researchers to discuss the latest advancements and challenges in oncology research. Interested in hearing more insights from Matt?

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Medical Xpress

DECEMBER 1, 2022

In 2021, a group of scientists led by researchers at the University of North Carolina at Chapel Hill, Weill Cornell Medicine and NewYork-Presbyterian reported that the Moderna mRNA vaccine and a protein-based vaccine candidate containing an adjuvant, a substance that enhances immune responses, elicited durable neutralizing antibody responses to SARS-CoV-2 (..)

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XTalks

DECEMBER 30, 2024

has announced promising Phase IIb results for cenerimod, an investigational drug targeting immune system dysfunction in moderate-to-severe systemic lupus erythematosus (SLE). SLE is an autoimmune disease where the immune system attacks healthy tissues, causing inflammation, pain and potential organ damage. Viatris Inc.

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Pharmaceutical Technology

MAY 12, 2023

The collaboration will use the integrated drug creation platform of Absci and the clinical immunology datasets from the Kennedy Institute to identify antibodies to immune-mediated inflammatory diseases and autoimmune conditions with unprecedented speed.

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Development Antibody Immune Response Genomics 130

Rethinking Clinical Trials

APRIL 18, 2023

There are many hypothesized causes that may co-exist in the same patient, such as persistent virus or antigens, reactivation of other viruses, uncontrolled immune responses, damage to a wide range of organs and tissues, and injury to blood vessels and abnormal blood clotting.

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Clinical Trials Clinical Trials Trials Immune Response 169

XTalks

JULY 31, 2024

Alopecia areata can be triggered by genetics, immune system dysfunction and environmental factors. Leqselvi works by selectively inhibiting the Janus kinases (JAK) JAK1 and JAK2, pathways that play a key role in this misguided immune response.

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Immune Response Dermatology Clinical Trials Clinical Trials 105

Olympian Clinical Research

MAY 6, 2024

These targeted therapies revolutionized treatment, offering relief to severe cases by specifically addressing the underlying immune responses causing the disease. If you or someone you know is struggling with plaque psoriasis, consider contacting Olympian Clinical Research.

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Clinical Research Immune Response Clinical Trials Clinical Trials 52

Cloudbyz

MARCH 5, 2024

They are often used to mimic or enhance natural biological processes, such as immune responses. Immunogenicity : Small Molecules: Generally have a lower risk of inducing an immune response in the body. Monitoring and managing immunogenicity is a complex aspect of clinical trials for biologics.

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Development Drugs Immune Response Manufacturing 97

pharmaphorum

SEPTEMBER 15, 2020

The antibody – called lenzilumab – targets colony stimulating factor 2 (CSF2) and granulocyte-macrophage colony stimulating factor (GM-CSF), two cytokines that are linked to the runaway immune response that can result in serious lung damage in COVID-19.

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XTalks

AUGUST 13, 2020

It is also dedicated to fostering innovations in care, clinical research, health education and the support of community health. Kaiser Permanente has been providing not-for-profit healthcare plans for Americans across the US for 75 years now.

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XTalks

DECEMBER 29, 2023

Tarlatamab is an investigational drug currently undergoing clinical trials to assess its efficacy in patients with two distinct types of neuroendocrine cancer: SCLC and neuroendocrine prostate cancer (NEPC).

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Clinical Trials Clinical Trials FDA Approval Trials 119

Olympian Clinical Research

NOVEMBER 30, 2023

Olympian Clinical Research: At the Forefront of Vitiligo Treatment Innovations At Olympian Clinical Research , we’re committed to advancing the treatment of vitiligo through cutting-edge clinical research. The post Innovations in Vitiligo Treatment appeared first on Olympian Clinical Research.

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Clinical Research Clinical Trials Clinical Trials Immune Response 52

Olympian Clinical Research

NOVEMBER 9, 2022

This therapy uses drugs such as azathioprine to suppress your body’s immune response. Change Your Outlook with Olympian Clinical Research. At Olympian Clinical Research, we are dedicated to helping those with bullous pemphigoid and other rare conditions through clinical research trials.

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Clinical Research Immune Response Research Trials 52

Olympian Clinical Research

NOVEMBER 16, 2022

HS is believed to develop due to an immune response that generates too much inflammation. People with HS may have an overactive immune system, which causes their bodies to overreact to the presence of a blocked hair follicle. Clinical Research on Hidradenitis Suppurativa. It’s also not caused by poor hygiene.

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Clinical Research Bacteria Dermatology Immune Response 52

The Pharma Data

NOVEMBER 22, 2020

We now have a pipeline of undisclosed therapeutic partnerships nearing clinical research. Dr António Parada, CEO at FairJourney Biologics and IONTAS, commented: “ Our teams have gained considerable experience in antibody discovery for use in generating mono-specific and bi-specific therapeutics.

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The Pharma Data

JANUARY 3, 2021

In addition, their collective research insights will greatly enhance existing efforts to translate the scientific potential of our AIM technology into therapies designed to address significant unmet patient needs.”. The backbone of NexImmune’s approach is its proprietary Artificial Immune Modulation (AIM TM ) nanoparticle technology platform.

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DM Clinical Research

JULY 30, 2021

Otherwise, you might not have the proper immune response reaction. DM Clinical Research is here to answer all of your vaccination questions. appeared first on DM Clinical. With all of that waiting, “can I get my second COVID vaccine early” is a natural question! But unfortunately, the answer is no.

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XTalks

SEPTEMBER 5, 2023

Finally, addressing the time-consuming and costly transition from non-clinical to clinical development due to difficulties in predicting human immune responses is another issue. Therefore, planned protocols should specify in detail methodologies to be used to evaluate immune responses to vaccination.

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XTalks

MARCH 13, 2023

Here are five key takeaways from the 90-minute FDA town hall that rare disease clinical research professionals need to know. Another thing Dr. Xu recommended is to monitor the immune response to gene therapy products.

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The Pharma Data

NOVEMBER 9, 2020

Combining ICIs with radiation therapy is emerging as a valuable strategy to “prime” an immune response and thereby increase the response rate, however the efficacy of radiation therapy is limited by toxicities related to the exposure of healthy tissues. NBTXR3 is injected one time, directly into solid tumors.

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Roots Analysis

MARCH 3, 2022

The complement-targeted therapeutics inhibit complement activation, thereby reducing tissue inflammation and dampening the adaptive immune response to foreign and tissue antigens. Next Generation Complement Therapeutics – Current Market Landscape. For further information on this domain, check out the report –.

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Drug Delivery Systems Marketing Immune Response Dermatology 52

XTalks

SEPTEMBER 21, 2023

The trial’s primary objective is to assess the safety of VIR-1388 and its capacity to stimulate a specific immune response against HIV in study participants. Vir Biotechnology, Inc., announced that the first participant has been dosed in a new Phase I trial for an innovative HIV vaccine candidate, VIR-1388.

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Vaccine Vaccination Trials Clinical Trials 59

Find Me Cure

OCTOBER 13, 2019

This Breast Cancer Awareness Month we’d like to talk about emerging areas in metastatic breast cancer treatment since clinical research has come so far in recent years. Some kinds of cancer can protect themselves from being attacked by the immune system by stimulating proteins that keep the immune response in check.

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The Pharma Data

NOVEMBER 10, 2020

Oral administration of anti-CD3 monoclonal antibody is a novel approach to induce an anti-inflammatory immune response to suppress inflammation by inducing T regulatory (Tregs) cells in animal studies 3 ,4. NEW YORK and LONDON, Nov. In a humanized mouse model (NOD/SCID IL2?c-/-),

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Cloudbyz

JULY 31, 2024

This revolution is enabling the growth of innovative biomarker-based precision medicine and cell and gene therapy, transforming both clinical research and post-market care. The landscape of modern medicine is rapidly evolving, driven by groundbreaking advancements in diagnostics.

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Pfizer

FEBRUARY 16, 2023

GCP is the international ethical and scientific quality standard for clinical trials that all clinical researchers need to follow. VLA15 has demonstrated a strong immune response and satisfactory safety profile in pre-clinical and clinical studies so far.

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XTalks

SEPTEMBER 17, 2020

While clinical researchers occasionally need to identify and validate a new surrogate endpoint for a given trial, choosing endpoints that have been previously used as the basis of NDAs and BLAs can clear the path to eventual approval.

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Trials Gene Hormones Clinical Trials 98

Worldwide Clinical Trials

MARCH 12, 2024

These markers can inform treatment response and help reduce patient radiation exposure by reducing the need for repeated imaging assessments in clinical trials.

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XTalks

OCTOBER 1, 2024

XTALKS CLINICAL EDGE: Issue 3 — Interview with Ethris’ Dr. Langenickel Xtalks Clinical Edge is a magazine for clinical research professionals and all who want to be informed about the latest trends and happenings in clinical trials.

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Velocity Clinical Research

MARCH 19, 2025

Early results from the Phase 1/2 trial show that the vaccine is well-tolerated and induces strong immune responses, potentially paving the way for a more convenient approach to respiratory virus prevention.

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Medicine Immune Response Vaccine Vaccination 52

Olympian Clinical Research

DECEMBER 19, 2023

With ongoing research and clinical trials , institutions like Olympian Clinical Research are at the forefront of finding innovative treatment options. For more severe cases, systemic medications, including newer biologics that target immune responses, are used. What is Pediatric Plaque Psoriasis?

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Advarra

JANUARY 11, 2024

The applications of mRNA-based therapies in cancer research represent one of the next groundbreaking steps toward improved cancer treatments. While mRNA usage has played several roles in clinical research , oncology researchers in particular are eager to explore the possibilities of mRNA-based cancer vaccines.

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The Pharma Data

JANUARY 17, 2021

It was co-sponsored by Merck and Bayer, conducted with the scientific oversight of the Canadian VIGOUR Centre and the Duke Clinical Research Institute. By inhibiting calcineurin, the drug blocks IL-2 expression and T-cell mediated immune responses. Aurinia Pharmaceutical’s Voclosporin for Lupus Nephritis.

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Manufacturing Immune Response Allergies Drugs 52

XTalks

SEPTEMBER 27, 2024

XTALKS CLINICAL EDGE: Issue 3 — Interview with Syncromune’s Dr. Link Xtalks Clinical Edge is a magazine for clinical research professionals and all who want to be informed about the latest trends and happenings in clinical trials.

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Immune Response Drugs Trials Clinical Trials 59

The Pharma Data

OCTOBER 19, 2020

The physical and universal mode of action (MoA) of NBTXR3 is designed to trigger cellular destruction death and adaptive immune response. The Company is also engaged in a broad, comprehensive clinical research collaboration with The University of Texas MD Anderson Cancer Center to further expand the NBTXR3 development program.

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